Investigation of anti-Toxoplasma gondii antibodies in patients with neoplasia

Abstract

TurkeyThis study aimed to determine the prevalence of anti-Toxoplasma gondii antibodies in patients with neoplasia. One hundred and eight patients with neoplasia and 108 healthy controls were studied for the presence of anti-T. gondii antibodies using a micro ELISA and peroxidase-labelled anti-human IgG (rabbit) and IgM (goat). Anti-T. gondii IgG antibodies were detected in 68 (63 . 0 %) patients and in 21 (19 . 4 %) of the controls, which was a statistically significant difference. In addition, anti-T. gondii IgM antibodies were detected in seven (6 . 5 %) patients and in one (0 . 9 %) control. A high percentage of positivity for Toxoplasma antibodies in patients with neoplasia was detected. Therefore, parasitological surveys of this patient group should be periodically performed.

Study the Possible Link Between Toxoplasmosis and Different Kinds of Cancer in Iraq

“…Similarly, Yazar et al [28] investigated the seropositivity rate of toxoplasmosis in Turkish patients with neoplasia to determine levels of anti-T. gondii IgG and IgM antibodies and their results revealed higher percentages of positivity for T. gondii IgG antibodies in patients with neoplasia (52.9%) compared with the controls (20%) with a statistically significant difference. The authors concluded that these findings may be due to the fact that patients with neoplasia are immunocompromised, which increases their susceptibility to infection with toxoplasmosis.…”

Detection of IgM and IgG anti-Toxoplasma antibodies in renal transplant recipients using ELFA, ELISA and ISAGA methods: comparison of pre- and post-transplantation status

“…For many years, toxoplasmosis has been considered as an opportunistic infection in immunocompromised patients (Hwa and Kim, 2004;Yazar et al, 2004;Yuan et al, 2007). Wulf et al (2005) have explained the problems of toxoplasmosis in RTRs such as lack of clinical awareness and difficulties in establishing a diagnosis.…”

A Trojan Horse in Intensive Care Unit: Toxoplasma gondii

“…Patients with neoplasia, collagen tissue disease, and transplant recipients under immunosuppressive therapy or haemodialysis patients with chronic renal failure have deficient cellular immunity, and this makes them susceptible to the infection. 5,6 In immunocompromised patients, the infection most often involves the nervous system, with diffuse encepha-lopathy, meningoencephalitis or cerebral mass lesions. 1 Critically ill patients frequently demonstrate profound immunity abnormalities due to their illness or to treatment regimes used.…”

“…1 Toxoplasmosis attains clinical significance in two major situations, as a cause of congenital infection and as an opportunistic infection with high mortality in immunosuppressed individuals. [2][3][4][5][6][7] Twenty percent of the U.S. population is seropositive for T. gondii immunoglobulin G (IgG), making this one of the most prevalent and probably the only chronic parasitic infection lasting a human lifetime. 8 Seropositivity rates for T. gondii in two large cities in Turkey were reported as 23.1% for İzmir and 36% for Kayseri.…”

“…8 Seropositivity rates for T. gondii in two large cities in Turkey were reported as 23.1% for İzmir and 36% for Kayseri. 9,10 The high seropositivity rates suggest that the majority of infections are mild, with most people exhibiting few (ie, cold or mild case of flu) or no symptoms. On the other hand, studies have shown higher rates of symptomatic infection in immunecompromised individuals such as those with HIV infection.…”