Investigation of antibacterial activity and related mechanism of a ruthenium(II) polypyridyl complex

Sun, Dongdong; Zhang, Weiwei; Yang, En-hui; Li, Nuan; Li, Haiping; Wang, Weiyun

doi:10.1016/j.inoche.2015.03.044

Cited by 9 publications

(7 citation statements)

References 34 publications

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“…Briefly, it may be stated that there is a lot yet to be done to explore anti-infectious potential of the metallic complexes in this regard by altering the nature of ligand around the coordination zone. Such results are comparable to the gasotransmitter models reported elsewhere [40,41,45,46,47,48].…”

Section: Antibacterial Activitysupporting

confidence: 91%

Formulation, Molecular Charge Topography, and Nosocomial Anti-Infectious Potential of Ruthenium Carbonyl Complex of N-o-Hydroxyacetophenone-Ethylenediamine-N′-o-Vanillin

Mir¹,

Jain²,

Maurya³

2021

J Trans Met Compl

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Nosocomial infections are ranked as the second-largest infections. E. coli is the primary causative agent of this dreadful infection. To develop effective antibiotic substances against hospitalacquired infections, herein a novel carbon monoxide tagged Ru(II) complex of N-o-hydroxyacetophenone-ethylenediamine-N -o-vanillin is reported as an effective antimicrobial agent of its form. In addition to molecular structure elucidation, an explanation has been made about the related charge topography concerning the biological effect. The formulation of the complex based on hyphenated experimentaltheoretical evaluation suggests an octahedral structure. Density functional study was carried out confined to the formalism as B3LYP functional/LanL2DZ basis set for Ru atom and 6-31 g(d,p) for the rest of the atoms. The stable form of geometry and other electron density plots are the prominent inclusions discussed in this work. The primary characterization techniques that have been used for the formulation include elemental analysis, mass spectrometry, nuclear magnetic resonance (C and H), UV-Vis, and FT-IR. The experimentally observed data was validated with theoretical/computational outputs. Both the experimental and theoretical results sound in excellent agreement when compared at each step of the characterization. A suitable trans-octahedral geometry has been suggested for the complex. From the antimicrobial actions against nosocomial E. coli, an MIC value of 30 μM was obtained for the selected compound and hence can be assumed as a standard novel antibiotic substance against nosocomial infections. The respective microbial study has been discussed, keeping in view the microbial growth study, the qualitative and quantitative analysis to add fascination to the work being reported.

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Section: Antibacterial Activitysupporting

confidence: 91%

Formulation, Molecular Charge Topography, and Nosocomial Anti-Infectious Potential of Ruthenium Carbonyl Complex of N-o-Hydroxyacetophenone-Ethylenediamine-N′-o-Vanillin

Mir¹,

Jain²,

Maurya³

2021

J Trans Met Compl

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“…The present study indicates that the antimicrobial polymeric [Ru(CO)2Cl2]n possess a very high activity with 99.9% removal of bacteria with concentration under light irradiation at nanogram/mL. (Liu et al, 2018;Sun et al, 2018;Smitten et al, 2020;Bolhuis et al, 2011;Sun et al, 2020;Sun et al, 2015;Kumar et al, 2009;Abebe and Hailemariam, 2016;Donnelly et al, 2007;Lam et al, 2014;Kumar et al, 2016;Pandrala et al, 2013). We have shown a unique photo-induced bacteria inactivation by using [Ru(CO)2Cl2]n and a plausible mechanism for the formation of oxidative species for light activated therapy.…”

Section: Antifouling Photo-bactericidal Activity Of Polymeric [Ru(co)2cl2]nmentioning

confidence: 57%

Polymeric ruthenium precursor as a photoactivated antimicrobial agent

Ghosh

Amariei

Mosquera

et al. 2021

Journal of Hazardous Materials

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Ruthenium coordination compounds have demonstrated a promising anticancer and antibacterial activity, but their poor water solubility and low stability under physiological conditions may limit their therapeutic applications. Physical encapsulation or covalent conjugation with polymers may overcome these drawbacks, but generally involve multistep reactions and purification processes. In this work, the antibacterial activity of the polymeric precursor dicarbonyldichlororuthenium (II) [Ru(CO)2Cl2]n has been studied against Escherichia coli and Staphylococcus aureus. This Ru-carbonyl precursor shows minimum inhibitory concentration at nanogram per millilitre, which renders it a novel antimicrobial polymer without any organic ligands. Besides, [Ru(CO)2Cl2]n antimicrobial activity is markedly boosted under photoirradiation, which can be ascribed to the enhanced generation of reactive oxygen species under UV irradiation. [Ru(CO)2Cl2]n has been able to inhibit bacterial growth via the disruption of bacterial membranes and triggering upregulation of stress responses as shown in microscopic measurements. The activity of polymeric ruthenium as an antibacterial material is significant even at 6.6 ng/mL while remaining biocompatible to the mammalian cells at much higher concentrations. This study proves that this simple precursor, [Ru(CO)2Cl2]n, can be used as an antimicrobial compound with high activity and a low toxicity profile in the context of need for new antimicrobial agents to fight bacterial infections.

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“…The prevalence of antibiotic resistance toward the traditional clinical drugs has stimulated the development of more novel and potent antibiotics, especially the metal-based antimicrobial agents over the past decade . A broad spectrum of organometallic complexes (e.g., Pt, Cu, Rh, and Ru − ) as antimicrobial agents have been synthesized and studied for their antimicrobial activity. Collins and Keene et al have reported a series of mononuclear [Ru-(phen) 2 (bb 7 )] 2+ and [Ru(phen) 2 (bb 16 )] 2+ , dinuclear [{Ru(phen) 2 } 2 {m-bb n }] 4+ , and oligonuclear Ru II complexes, where bb n is bis[4(4′-methyl-2,2′-bipyridyl)]-1, n -alkane ( n = 7, 12, or 16, etc.…”

Section: Discussionmentioning

confidence: 99%

Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity

et al. 2018

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We have synthesized novel organoiridium(III) antimicrobial complexes containing a chelated biguanide, including the antidiabetic drug metformin. These 16- and 18-electron complexes were characterized by NMR, ESI-MS, elemental analysis, and X-ray crystallography. Several of these complexes exhibit potent activity against Gram-negative bacteria and Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus (MRSA)) and high antifungal potency toward C. albicans and C. neoformans, with minimum inhibitory concentrations (MICs) in the nanomolar range. Importantly, the complexes exhibit low cytotoxicity toward mammalian cells, indicating high selectivity. They are highly stable in broth medium, with a low tendency to generate resistance mutations. On coadministration, they can restore the activity of vancomycin against vancomycin-resistant Enterococci (VRE). Also the complexes can disrupt and eradicate bacteria in mature biofilms. Investigations of reactions with biomolecules suggest that these organometallic complexes deliver active biguanides into microorganisms, whereas the biguanides themselves are inactive when administered alone.

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Investigation of antibacterial activity and related mechanism of a ruthenium(II) polypyridyl complex

Cited by 9 publications

References 34 publications

Formulation, Molecular Charge Topography, and Nosocomial Anti-Infectious Potential of Ruthenium Carbonyl Complex of N-o-Hydroxyacetophenone-Ethylenediamine-N′-o-Vanillin

Formulation, Molecular Charge Topography, and Nosocomial Anti-Infectious Potential of Ruthenium Carbonyl Complex of N-o-Hydroxyacetophenone-Ethylenediamine-N′-o-Vanillin

Polymeric ruthenium precursor as a photoactivated antimicrobial agent

Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity

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