Investigation of antibiotics in mollusks from coastal waters in the Bohai Sea of China

Li, Wenhui; Shi, Yunfeng; Gao, Lihong; Liu, Jiemin; Cai, Yaqi

doi:10.1016/j.envpol.2011.10.022

Cited by 111 publications

(56 citation statements)

References 31 publications

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“…The anti-depressant sertraline was detected at 43 of 68 mussels sampling stations along the California Coast [81]. Antibiotics were detected in 142 out of 190 mollusc samples collected from nine cities along the Bohai Sea in China [82]. Detectable concentrations of pharmaceuticals were measured in wild seafood samples purchased from Czech supermarkets including squid caught in the Eastern Central Pacific, herring from the Atlantic Northeast and shark from the Eastern Central Atlantic [83].…”

Section: (D) Marine Biotamentioning

confidence: 99%

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Sources, impacts and trends of pharmaceuticals in the marine and coastal environment

Gaw

Thomas

Hutchinson

2014

Phil. Trans. R. Soc. B

385

149

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There has been a significant investment in research to define exposures and potential hazards of pharmaceuticals in freshwater and terrestrial ecosystems. A substantial number of integrated environmental risk assessments have been developed in Europe, North America and many other regions for these situations. In contrast, comparatively few empirical studies have been conducted for human and veterinary pharmaceuticals that are likely to enter coastal and marine ecosystems. This is a critical knowledge gap given the significant increase in coastal human populations around the globe and the growth of coastal megacities, together with the increasing importance of coastal aquaculture around the world. There is increasing evidence that pharmaceuticals are present and are impacting on marine and coastal environments. This paper reviews the sources, impacts and concentrations of pharmaceuticals in marine and coastal environments to identify knowledge gaps and suggests focused case studies as a priority for future research.

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Section: (D) Marine Biotamentioning

confidence: 99%

“…Fluoxetine tissue concentrations in Mytilus gallioprovincialis followed the order digestive gland.gills.mantle/gonads [86]. Li et al [82] reported differences in uptake of antibiotics between mollusc species harvested from the Bohai Sea, China. In some situations, gender may also influence uptake of pharmaceuticals by marine organisms.…”

Section: (D) Marine Biotamentioning

confidence: 99%

Sources, impacts and trends of pharmaceuticals in the marine and coastal environment

Gaw

Thomas

Hutchinson

2014

Phil. Trans. R. Soc. B

385

149

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“…Our detected levels were then compared at the end of Section 3.2, ( line 324) by adding: "Low antibiotic concentrations were also reported in the study of Dodder et al (2014), where they studied and found only few target antibiotics (lomefloxacin, enrofloxacin, sulfamethazine and erythromycin at the mean concentrations of 29, 1.3, 24 and 0.14 ng g -1 dry weight, respectively) but with a higher detection frequency from 17 to 94 % related to 68 mussel sampling stations of the coast of California collected from November 2009 and April 2010. Our results were reassuring if compared with the study of Li et al (2012), where all 22 target antibiotics of three classes, except tylosin were detected in the 190 molluscs samples of Bohai Sea of China. Their results, showed quinolones as the major compounds with concentrations of 0.71-1575.10 µg kg -1 , which were up to two orders of magnitude higher than those of sulphonamides (0-76.75 µg kg -1 ) and macrolides (0-36.21 µg kg -1 ).…”

Section: Line 198mentioning

confidence: 52%

Occurrence of antibiotics in mussels and clams from various FAO areas

et al. 2018

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Filter feeders, like mussels and clams, are suitable bioindicators of environmental pollution. These shellfish, when destined for human consumption, undergo a depuration step that aims to nullify their pathogenic microorganism load and decrease chemical contamination. Nevertheless, the lack of contamination by drugs may not be guaranteed. Antimicrobials are a class of drugs of particular concern due to the increasing phenomenon of antibiotic resistance. Their use in breeding and aquaculture is a major cause of this. We developed a multiclass method for the HPLC-MS/MS analysis of 29 antimicrobials, validated according to the Commission Decision 2002/657/UE guidelines, and applied it to 50 mussel and 50 clam samples derived from various Food and Agricultural Organisation marine zones. The results obtained, indicate a negligible presence of antibiotics. Just one clam sample showed the presence of oxytetracycline at a concentration slightly higher than the European Union Maximum residue limit set for fish. The topic of antibiotic resistance drives more and more the search for contaminants in food towards this class of pharmacological compounds. Although bivalve molluscs are bred offshore, where the antibiotics, eventually illicitly used, could undergo a drastic dilution, these filter-feeding animals, may constitute a means for the bio accumulation of antimicrobials and the distribution through the food chain from the aquatic environment to consumers. We used a validated multiclass method for the HPLC-MS/MS analysis of 29 antimicrobials, and the results of our work are very reassuring for the consumer indicating a very low presence and frequency of antibiotics in the edible tissue of mussels and clams; at the same time it could be hypothesized that the illegal treatment takes place in the purification stage prior to sale.The provenience of the molluscs from various FAO marine areas, even if mostly from the Mediterranean Sea, could be an added value of the study, also accounting that the samples were collected at the Milan fishery market, which supplies all Italy, so being a verisimilar representation of the molluscs consumed by Italian people.Before the submission, the British English was checked and revised by Proof-reading.com. Italy PS; after your request we referenced the 10% similarities you found with iThenticate. The citations were two: all belonging to our research group and dealt with Materials and Methods. This was an imprecision but, as an excusatory, we did not try to auto-cite at any cost. Obviously we added in references the two works We are very grateful to Editor for the opportunity to improve our research and to the reviewers for their helpful comments. We carefully followed their suggestions as well as the Food Chemistry author guidelines in order to make the manuscript more clear and as complete as possible. Therefore, the manuscript was managed as indicated by the reviewers and the editor. A professional English editor carefully revised the manuscript.We hope that the reviewer's suggesti...

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“…The concentration of ibuprofen determined in the fish plasma and bile samples was 100 to 1000-fold higher than in corresponding water samples (Jeffries et al 2015). Some antibiotics, particularly quinolones, can bioaccumulate at relatively high levels in molluscs (Li et al 2012). Anti-depressants were also found to bioaccumulate in periphyton, snails (Du et al 2015), benthic invertebrates (Grabicova et al 2015), bivalves (Bringolf et al 2010) and the muscles of fish species used for human consumption (Brooks et al 2005).…”

Section: Fate Of Pharmaceuticals In the Freshwater Environmentmentioning

confidence: 97%

Pharmaceutical pollution of aquatic environment: an emerging and enormous challenge

Rzymski

Drewek

Klimaszyk

2017

Limnological Review

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Abstract:The global use of pharmaceuticals is on the systematic rise and leads to contamination of surface waters with xenobiotic compounds with a wide range of bioactivity. Waters that receive urban and medical effluents are particularly threatened. The presence of pharmaceuticals in these ecosystems can lead to unpredictable ecological impacts and responses, and may also have an impact on human health. At the same time the identification and quantification of these chemicals, to a large extent remains a subject to scientific investigation than part of a thorough monitoring programme. Their biological effects on aquatic organisms are mainly recognized experimentally and often using concentrations far exceeding environmentally relevant levels. This review paper defines the main sources of pharmaceuticals in the aquatic environment, discusses the fate of these compounds and summarizes the current state-of-the-art of pharmaceutical monitoring in Polish surface waters.

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Investigation of antibiotics in mollusks from coastal waters in the Bohai Sea of China

Cited by 111 publications

References 31 publications

Sources, impacts and trends of pharmaceuticals in the marine and coastal environment

Sources, impacts and trends of pharmaceuticals in the marine and coastal environment

Occurrence of antibiotics in mussels and clams from various FAO areas

Pharmaceutical pollution of aquatic environment: an emerging and enormous challenge

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