Investigation of antileishmanial activities of CaO nanoparticles on L. tropica and L. infantum parasites, in vitro

Ghaffari, Ali; Barati, Mohammad; Ghaffarifar, Fatemeh; Pirestani, Majid; Ebrahimi, Mohsen; KarimiPourSaryazdi, Amir

doi:10.1007/s12639-022-01539-6

Cited by 3 publications

(2 citation statements)

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“…126−131 These MO-NPs exhibit antimicrobial properties with fewer side effects and lower toxicity to humans compared to traditional drugs. 132 Metallic Oxide Nanoparticles. Metallic oxide nanoparticles (MO-NPs), especially those formed by transition metals ions with unfilled d-shells, facilitate electronic transitions, providing unique electronic properties.…”

Section: ■ Scope and Motivation Of Reviewmentioning

confidence: 99%

“…A variety of metallic oxide nanoparticles (MO-NPs) such as ZnO, TiO 2 , CaO, AgO, Co 3 O 4 and MgO, are being considered as alternative treatment for infectious diseases. Their surface composition, charge, area, and small dimensions allow them to penetrate cells and disrupt the DNA and enzymes of the infectious agents, making them particularly interesting for treating Leishmaniasis. − These MO-NPs exhibit antimicrobial properties with fewer side effects and lower toxicity to humans compared to traditional drugs …”

Section: Inorganic Materials To Treat Leishmaniasismentioning

confidence: 99%

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Innovating Leishmaniasis Treatment: A Critical Chemist’s Review of Inorganic Nanomaterials

Bessa,

D’Amato,

C. Souza

et al. 2024

ACS Infect. Dis.

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Leishmaniasis, a critical Neglected Tropical Disease caused by Leishmania protozoa, represents a significant global health risk, particularly in resource-limited regions. Conventional treatments are effective but suffer from serious limitations, such as toxicity, prolonged treatment courses, and rising drug resistance. Herein, we highlight the potential of inorganic nanomaterials as an innovative approach to enhance Leishmaniasis therapy, aligning with the One Health concept by considering these treatments' environmental, veterinary, and public health impacts. By leveraging the adjustable properties of these nanomaterials�including size, shape, and surface charge, tailored treatments for various diseases can be developed that are less harmful to the environment and nontarget species. We review recent advances in metal-, oxide-, and carbon-based nanomaterials for combating Leishmaniasis, examining their mechanisms of action and their dual use as standalone treatments or drug delivery systems. Our analysis highlights a promising yet underexplored frontier in employing these materials for more holistic and effective disease management.

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Section: ■ Scope and Motivation Of Reviewmentioning

confidence: 99%