Investigation of antioxidant, antibacterial, antiviral, chemical composition, and traditional medicinal properties of the extracts and essential oils of the <i>Pimpinella</i> species from a broad perspective: a review

Nasır, Abir; Yabalak, Erdal

doi:10.1080/10412905.2021.1928559

Cited by 17 publications

(13 citation statements)

References 59 publications

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“…Bulgarian fennel seed extract had low antiradical activity (IC50 = 113.19 mL/L), according to [66]. Previous research has shown that essential oils and extracts of aniseed have antioxidant properties [46,67]. Our knowledge of these compounds from aniseed is limited.…”

Section: Discussionmentioning

confidence: 98%

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

et al. 2023

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Aniseeds (Pimpinella anisum) have gained increasing attention for their nutritional and health benefits. Aniseed extracts are known to contain a range of compounds, including flavonoids, terpenes, and essential oils. These compounds have antimicrobial properties, meaning they can help inhibit the growth of nasty bacteria and other microbes. The purpose of this study was to determine if aniseed extracts have potential antioxidant, phytochemical, and antimicrobial properties against multidrug-resistant (MDR) bacteria. A disc diffusion test was conducted in vitro to test the aniseed methanolic extract’s antibacterial activity. The MIC, MBC, and inhibition zone diameters measure the minimum inhibitory concentration, minimum bactericidal concentration, and size of the zone developed when the extract is placed on a bacterial culture, respectively. HPLC and GC/MS are analytical techniques used for identifying the phenolics and chemical constituents in the extract. DPPH, ABTS, and iron-reducing power assays were performed to evaluate the total antioxidant capacity of the extract. Using HPLC, oxygenated monoterpenes represented the majority of the aniseed content, mainly estragole, cis-anethole, and trans-anethole at 4422.39, 3150.11, and 2312.11 (g/g), respectively. All of the examined bacteria are very sensitive to aniseed’s antibacterial effects. It is thought that aniseed’s antibacterial activity could be attributed to the presence of phenolic compounds which include catechins, methyl gallates, caffeic acid, and syringic acids. According to the GC analysis, several flavonoids were detected, including catechin, isochiapin, and trans-ferulic acid, as well as quercitin rhamnose, kaempferol-O-rutinoside, gibberellic acid, and hexadecadienoic acid. Upon quantification of the most abundant estragole, we found that estragole recovery was sufficient for proving its antimicrobial activity against MDR bacteria. Utilizing three methods, the extract demonstrated strong antioxidant activity. Aniseed extract clearly inhibited MDR bacterial isolates, indicating its potential use as an anti-virulence strategy. It is assumed that polyphenolic acids and flavonoids are responsible for this activity. Trans-anethole and estragole were aniseed chemotypes. Aniseed extracts showed higher antioxidant activity than vitamin C. Future investigations into the compatibility and synergism of aniseed phenolic compounds with commercial antibacterial treatments may also show them to be promising options.

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Section: Discussionmentioning

confidence: 98%

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

et al. 2023

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“…Essential oil extracted from P. impinella species has been found to counteract both Gram-negative and Gram-positive bacteria ( Nasır and Yabalak, 2021 ). In an animal study, anethole opposed E. coli K88, enriched the abundance of beneficial flora, protected intestinal barrier function, upregulated mucosal layer and tight junction proteins, reduced plasma concentrations of IL-1β and TNF-α ( p < 0.1), and decreased the mRNA expression of TLR5, TLR9, MyD88, IL-1β, TNF-α, IL-6, and IL-10 ( Yi et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of aniseed powder for treating gastrointestinal symptoms of COVID-19: a randomized, placebo-controlled trial

Mosaffa-Jahromi,

Molavi Vardanjani,

Fuzimoto

et al. 2024

Front. Pharmacol.

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Background: Gastrointestinal symptoms are prevalent amongst patients with a confirmed diagnosis of COVID-19 and may be associated with an increased risk of disease severity. This trial aimed to evaluate the efficacy and safety of aniseed (Pimpinella anisum L.) powder as an add-on therapy to standard care for treating gastrointestinal symptoms experienced by adults with an acute SARS-CoV-2 infection.Methods: The study was a randomized parallel-group double-blinded placebo-controlled add-on therapy trial. Adults with an acute SARS-CoV-2 infection who did not require hospitalization and reported at least one gastrointestinal symptom in the preceding 48 h were assigned to either the aniseed or placebo group in a 1:4 ratio. All 225 participants (45 in the aniseed group and 180 in the placebo group) were instructed to use 25 g of powdered aniseed or placebo twice daily for 2 weeks. The primary outcomes were the proportion of patients who experienced an improvement of at least one point in the symptom score after adjusting for age group, gender, and time. Backwards stepwise logistic regression was applied to calculate the risk ratios. The clinical symptoms and adverse events were assessed at the beginning, 1 week later, and at the end of the trial (week two).Results: Participants in the aniseed group were significantly more likely to report symptom improvement for abdominal pain [adjusted risk ratio (RR):0.55; 95% confidence interval (CI): 0.46–0.72], anorexia (RR:0.62; 95% CI: 0.47–0.82), and diarrhea (RR:0.19; 95% CI: 0.12–0.30), but not nausea/vomiting (RR:0.87; 95% CI: 0.71–1.08) or bloating (RR:0.87; 95% CI: 0.72–1.05). Two participants in the aniseed group and three participants in the placebo group reported mild to moderate adverse events.Conclusion: This study showed that 2 weeks of aniseed powder containing trans-anethole (87%–94%) may help improve abdominal pain, anorexia, and diarrhea in COVID-19 patients. The findings align with the known biological, multitargeted activity of P. anisum and trans-anethole, which includes inhibiting SARS-CoV-2 along with other anti-infective, anti-inflammatory, antioxidant, hepatoprotective, and anti-dysbiosis properties. Multicenter trials with larger sample sizes and longer follow-up are warranted to confirm these findings.Clinical Trial Registration: Iranian Registry of Clinical Trials (IRCT20120506009651N3).

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“…Throughout the construction of the ANN model, input data were frequently inserted in the network [31][32][33]. The training process of the network was replicated 100,000 times, testing the various structures of the ANN model, including a diverse number of neurons in the hidden and the output layers (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), alternative activation functions (in particular, logarithmic, tangent hyperbolic, logistic or identity), and with random starting values of weight coefficients and biases. The ANN structure optimization was accomplished by achieving the minimal validation error.…”

Section: Ann Modellingmentioning

confidence: 99%

“…Aniseed can be found in seafood dishes to enhance sweet breath and provide digestive support [12,13]. The essential oils of anise seeds are multicomponent blends of volatile oils, typically terpenes and their derivatives, containing nearly 4% of essential oil (E-Anethole conveys 90% of these essential oils, including stragol, anisaldehyde, γ-himachalene, isoeugenol, anisol, p-anisic acid and acetoanisol) [14]. Besides essential oil, aniseeds also contain a significant amount of antioxidants, including phenolic acids and flavonoids [15].…”

Section: Introductionmentioning

confidence: 99%

Agricultural Parameters and Essential Oil Content Composition Prediction of Aniseed, Based on Growing Year, Locality and Fertilization Type—An Artificial Neural Network Approach

Pezo

Lončar

Šovljanski

et al. 2022

Life

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Predicting yield is essential for producers, stakeholders and international interchange demand. The majority of the divergence in yield and essential oil content is associated with environmental aspects, including weather conditions, soil variety and cultivation techniques. Therefore, aniseed production was examined in this study. The categorical input variables for artificial neural network modelling were growing year (two successive growing years), growing locality (three different locations in Vojvodina Province, Serbia) and fertilization type (six different treatments). The output variables were morphological and quality parameters, with agricultural importance such as plant height, umbel diameter, number of umbels, number of seeds per umbel, 1000-seed weight, seed yield per plant, plant weight, harvest index, yield per ha, essential oil (EO) yield, germination energy, total germination, EO content, as well as the share of EOs compounds, including limonene, cis-dihydro carvone, methyl chavicol, carvone, cis-anethole, trans-anethole, β-elemene, α-himachalene, trans-β-farnesene, γ-himachalene, trans-muurola-4(14),5-diene, α-zingiberene, β-himachalene, β-bisabolene, trans-pseudoisoeugenyl 2-methylbutyrate and epoxy-pseudoisoeugenyl 2-methylbutyrate. The ANN model predicted agricultural parameters accurately, showing r2 values between 0.555 and 0.918, while r2 values for the forecasting of essential oil content were between 0.379 and 0.908. According to global sensitivity analysis, the fertilization type was a more influential variable to agricultural parameters, while the location site was more influential to essential oils content.

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Investigation of antioxidant, antibacterial, antiviral, chemical composition, and traditional medicinal properties of the extracts and essential oils of the Pimpinella species from a broad perspective: a review

Cited by 17 publications

References 59 publications

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

Efficacy and safety of aniseed powder for treating gastrointestinal symptoms of COVID-19: a randomized, placebo-controlled trial

Agricultural Parameters and Essential Oil Content Composition Prediction of Aniseed, Based on Growing Year, Locality and Fertilization Type—An Artificial Neural Network Approach

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