Investigation of antitussive and toxicological activity of<i>Ballota limbata</i>in mice

Haq, Rizwan ul; Farooq, Umar; Wahab, Abdul; Raza, Mohsin; Ahmad, Viqar Uddin; Khan, Rafeeq Alam

doi:10.3109/13880209.2011.563317

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…The extract of B. limbata (Pakistan) leaves in n-buthanol was active as antitussive by reducing the SO 2 -induced cough in mice. The treatment of animals with 800 mg/kg b. w. of the extract caused the cough episodes to be reduced from 46 to 12 in 60 min; an efficacy analogous to that of the standard antitussive drugs codeine and dextromethorphan [279]. The toxicity test proved the extract to be inoffensive until the dose of 5000 mg/g b. w.…”

Section: Effects On Central Nervous Systemmentioning

confidence: 93%

A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia

2019

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The genus Ballota, belonging to Lamiaceae family (Stachyoideae/ Lamioideae subfamily) [1,2], is, apart from the South African endemic species Ballota africana (L.) Benth., naturally distributed in the Mediterranean, the Middle East and in North Africa. Some species (e.g., Ballota nigra L. s. l.) are also present over large areas of western, central, and northern Europe, and 4 species, whose status will be discussed later, in Somalia.Ballota species are perennial herbs or small shrubs with branched and/or simple hairs, toothed and petiolate leaves, the inflorescence thyrsoid or racemoid sometimes has long and spinose bracteoles (sect. Acanthoprasium), and the calyx is mostly campanulate, purple to white.A former classification of the genus identified the occurrence of 31 species (1 = Ballota integrifolia Benth. -2 = Ballota wettsteinii Rech. pat. -3 = Ballota frutescens (L.) Woods -4 = Ballota fruticosa Baker -5 = Ballota somala Patzak -6. Ballota andreuzziana Pamp. -7 = Ballota acetabulosa (L.) Benth. -8 = Ballota undulata (Sieb, ex Fres.) Benth. -9 = Ballota pseudodictamnus (L.) Benth. -10 = Ballota damascena Boiss. -11 = Ballota hildebrandtii Vatke et Kurtz -12 = Ballota hirsuta Benth. -13 = Ballota bullata Pomel -14 = B. africana (L.) Benth. -15 = Ballota aucheri Boiss. -16 = Ballota macrodonta Boiss. et Bal. -17 = Ballota larendana Boiss. et Heldr. -18 = Ballota rotundifolia C. Koch -19 = Ballota rupestris (Biv.) Vis. -20 = Ballota macedonica Vand. -21 = Ballota kaiseri V. Täckh. -22 = Ballota antilibanotica Post -23 = Ballota cristata Davis -24 = Ballota semanica Rech. f. -25 = Ballota labillardieri Briq. -26 = Ballota saxatilis Sieb. ex J. et C. Presl -27 = Ballota stachydiformis Höchst. -28 = Ballota philistea Bomm. -29 = Ballota platylomaThe 2 genera Ballota and Otostegia, belonging to the Lamiaceae family, are closely related taxonomically and found mainly in the Mediterranean area, Middle East, and North Africa. Since ancient times, they have been largely employed in traditional medicine for their biological properties such as antimicrobial, anti-inflammatory, antispasmodic, insecticidal, anti-malaria, etc. Phytochemical investigations of Ballota and Otostegia species have revealed that diterpenoids are the main constituents of the genera. A large number of flavonoids and other metabolites were also identified. This review, covering literature from 1911 up to 2018, includes traditional uses, chemical profiles (both of volatile and nonvolatile metabolites), and biological properties of all the taxa of these 2 genera studied to date.

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Section: Effects On Central Nervous Systemmentioning

confidence: 93%

A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia

2019

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“…Opium, Ammi , coltsfoot, plantain ma huang, thyme, and so forth are used from centuries in folklore to treat coughs and other pulmonary ailments. Frequent reports have been published in the botanical and ethnopharmacological literature suggesting that traditional antitussive plants from Europe, Asia, Africa, and elsewhere may offer significant cough suppressive effects (e.g., see [5–7]). Numerous compounds such as codeine, morphine, noscapine, bromhexine, guaifenesin, ephedrine, cromolyn, and their derivatives, isolated from different plant species, are well-established western medicines for treating cough or underlying pathologies [8].…”

Section: Introductionmentioning

confidence: 99%

“…Sulphur dioxide gas has been used to elicit cough in various experimental animals, for example, in cats [13], in rats [14], in mice [5], and so forth. In present studies, sulphur dioxide gas induced murine cough models, developed by Miyagoshi and colleagues in 1986 [5] were used to investigate antitussive efficacy of testing materials (see also [6, 7]).…”

Section: Introductionmentioning

confidence: 99%

Antitussive Efficacy and Safety Profile of Ethyl Acetate Fraction ofTerminalia chebula

et al. 2013

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Antitussive effects of ethyl acetate fraction of Terminalia chebula on sulphur dioxide (SO2) gas induced cough have been examined in mice. Safety profile of Terminalia chebula was established by determining LD50 and acute neurotoxicity. The result showed that extract of Terminalia chebula dose dependently suppressed SO2 gas induced cough in mice. Terminalia chebula, after i.p. administration at dose level 500 mg/kg, offered maximum cough suppressive effects; that is, number of coughs at 60 min was 12 ± 1.52 (mean ± SEM) as compared to codeine 10 mg/kg; i.p., dextromethorphan 10 mg/kg; i.p., and saline, having frequency of cough 10.375 ± 0.866, 12.428 ± 0.81, and 46 ± 2.61, respectively. LD50 value of Terminalia chebula was approximately 1265 mg/kg, respectively. No sign of neural impairment was observed at antitussive doses of extract. Antitussive effect of Terminalia chebula was partly reversed with treatment by naloxone (3 mg/kg; s.c.) while rimcazole (3 mg/kg; s.c.) did not antagonize its cough suppression activity. This may suggest that opioid receptors partially contribute in antitussive action of Terminalia chebula. Along with this, the possibility of presence of single or multiple mechanisms activated by several different pharmacological actions (mainly anti-inflammatory, antioxidant, spasmolytic, antibacterial, and antiphlegmatic) could not be eliminated.

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Polarity guided extraction, HPLC based phytochemical quantification, and multimode biological evaluation of Otostegia limbata (Benth.) Boiss

Fatima

Kainat

Akbar

2022

Arabian Journal of Chemistry

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Investigation of antitussive and toxicological activity ofBallota limbatain mice

Cited by 5 publications

References 26 publications

A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia

A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia

Antitussive Efficacy and Safety Profile of Ethyl Acetate Fraction ofTerminalia chebula

Polarity guided extraction, HPLC based phytochemical quantification, and multimode biological evaluation of Otostegia limbata (Benth.) Boiss

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