Flow and heat transfer characteristics of mist/steam cooling and mist/air cooling in a square channel with 60º rib angle are numerically investigated for a wide range of operating parameters, such as Reynolds number ranging from 10,000 to 60,000, reference pressure from 0.1MPa to 0.5MPa and inlet temperature from 120℃ to 200℃. Also, the heat transfer characteristics of mist cooling are compared with the corresponding experiment ofcases of single-phase coolant such as steam and air. The 3D steady Reynolds-averaged Navier-Stokes equations with a standard k (insert symbol instead of figure in abstract) turbulent model are solved by using commercial software ANSYS CFX. The CFD model has been validated by experimental data for steam-only case with a good agreement. In addition, distribution and evolution of secondary flow in the ribbed channel are analyzed by vortex core technology and theirits effects on heat transfer isare investigated for these four coolants. The results show that the strength of longitudinal secondary flow has a great significant influence on the Nusselt number (Nu) distribution on the ribbed surface. The NuNusselt number distribution is values are periodicallly distributed in stream-wise direction for steam and air cooling, whereas those areNusselt number gradually increased increases along the same direction for mist/steam and mist/air cooling. The parameter study suggests that heat transfer characteristics of mist cooling are insensitive to pressure, but inversely correlated with coolant inlet temperature compared with steam and air cooling.