Investigation of association between <i>LINC00673</i> rs11655237 C&gt;T and Wilms tumor susceptibility

Gao, Xin; Jia, Wei Hua; Zhu, Jinhong; Fu, Wen; Zhu, Shi-En; Xia, Huimin; He, Jing; Liu, Guochang

doi:10.1002/jcla.22930

Cited by 5 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 17 ] Gao et al showed that LINC00673 rs11655237 C> T polymorphism was not significantly associated with Wilms tumor susceptibility under all the tested genetic models (CT vs CC: OR = 0.94, 95% CI = 0.63–1.40; TT vs CC: OR = 0.60, 95% CI = 0.22–1.59; TT/CT vs CC: OR = 0.89, 95% CI = 0.61–1.31; and TT vs CC/CT: OR = 0.61, 95% CI = 0.23–1.61). [ 14 ] Wang et al found rs11655237 significantly increased susceptibility of cervical cancer in a Chinese population (OR = 1.27, 95% CI = 1.08–1.50; P = .005). [ 16 ] Zheng et al pointed out that LINC00673 rs11655237C>T is associated with pancreatic cancer susceptibility and indicates that, CT genotype carriers have a 28% increased risk of pancreatic cancer compared with CC genotype (OR = 1.28, 95% CI = 1.16–1.41, P = .121).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between the LINC00673 rs11655237 C> T polymorphisms with cancer risk in the Chinese population: A meta-analysis

Zhang¹,

Wu²,

Liang³

et al. 2022

Medicine

View full text Add to dashboard Cite

Objectives: The present study aimed to conduct a meta-analysis of previously published studies in order to clarify the association of long noncoding RNA (lncRNAs) LINC00673 rs11655237 C> T polymorphism with cancer risk. Design: Systematic review and meta-analysis. Setting: Electronic databases of PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, and Wanfang Database were used to search relevant studies. Studies published up to October 20, 2019 were included. The included studies were assessed in the following genetic model: allelic model, homozygote model, Heterozygote model, dominant model, recessive model. Data syntheses were conducted using STATA 12.0. Participants: Participants with various types cancers were included. Primary and secondary outcome measures: Odds ratio (ORs) and 95% confidence interval (CIs) were calculated to assess the risk of tumor. Results: Seven articles including 7 case-control studies, 7423 cases and 11,049 controls were adopted for meta-analysis. Our result demonstrated that LINC00673 rs11655237 C> T was related to the cancer among all model including allelic model (T vs C: pooled OR = 1.24, 95% CI = 1.16–1.41, P < .001), homozygous model (TT vs CC: pooled OR=1.54, 95% CI = 1.36–1.76, P < .001), heterozygous model (CT vs CC: pooled OR=1.24, 95% CI = 1.16–1.32, P < .001), dominant model (CT + TT vs CC: pooled OR=1.28, 95% CI = 1.20–1.36, P < .001) and recessive model (TT vs CT+ CC: pooled OR=1.42, 95% CI = 1.25–1.61, P < .001). Subgroup analysis also demonstrated that polymorphisms at this site also increased the risk of neuroblastoma. Conclusions: Our results find that rs11655237 contributed to occurrence of cancer in all models in Chinese population.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Finally, 7 articles including 7 case-control studies, 7423 cases and 11,049 controls were identified as suitable for meta-analysis. [14][15][16][17][18][19][20] The flow of the study is shown in Figure 1.…”

Section: Literature Searchmentioning

confidence: 99%

Association between the LINC00673 rs11655237 C> T polymorphisms with cancer risk in the Chinese population: A meta-analysis

Zhang¹,

Wu²,

Liang³

et al. 2022

Medicine

View full text Add to dashboard Cite

show abstract

“…To date, several studies have investigated the effect of rs11655237 polymorphism on cancer susceptibility, but the findings were inconsistent. For example, Gao X et al [21] found that there is a lack of relationship of rs11655237 with Wilms tumor risk. However, Yang T et al [22] reported that rs16901946 is correlated with an increased risk of neuroblastoma.…”

Section: E Discussionmentioning

confidence: 99%

“…

several studies have examined the correlation between the rs11655237 and the susceptibility to gastric cancer, Wilms tumor, hepatoblastoma, neuroblastoma, and cervical cancer [18][19][20][21][22][23][24][25]. Nevertheless, the obtained findings were controversial and inconclusive.

…”

mentioning

confidence: 99%

The Significant Contribution of LINC00673 Rs11655237 C > T Polymorphism to Cancer Susceptibility in Chinese Population: A Meta-analysis of The Current Literature

X¹,

Du²,

Li³

et al. 2021

J NUTR ONCOL

View full text Add to dashboard Cite

Objective Considerable studies exploring the relation of rs11655237 C > T polymorphism in the LINC00673 gene with cancer susceptibility have obtained debatable results. This meta-analysis aims to accurately assess this association. Methods Relevant studies with an updated date of April 20, 2021, were extensively searched from Embase, PubMed, Web of Science, Google Scholar, Medline, CNKI, and Chinese Wanfang databases. The strength of association was estimated by odds ratios (ORs) and 95% confdence intervals (CIs). Results A total of 8 articles involving 7,893 cases and 12,446 controls were ultimately selected in this analysis. Summary results revealed a signifcantly enhanced risk of cancer was related to LINC00673 rs11655237 C > T polymorphism for the allele model (OR = 1.22, 95% CI = 1.09-1.36), homozygote model (OR = 1.47, 95% CI = 1.30-1.67), heterozygote model (OR = 1.21, 95% CI = 1.14-1.29), dominant model (OR = 1.25, 95% CI = 1.18-1.32), and recessive model (OR = 1.26, 95% CI = 1.12-1.43). Moreover, subgroup analysis by cancer type showed LINC00673 rs11655237 C > T polymorphism contributed to the increased risk of neuroblastoma in the heterozygote, homozygote, dominant and recessive models. Conclusion The present meta-analysis indicates that LINC00673 rs11655237 C > T polymorphism is related to increased cancer susceptibility in the Chinese population. It may be a potential predictive biomarker of cancer risk.

show abstract

LINC00673 rs11655237 C>T and susceptibility to Wilms tumor: A five‐center case–control study

Li¹,

Han³

et al. 2019

The Journal of Gene Medicine

View full text Add to dashboard Cite

BackgroundWilms tumor, a frequently occurring pediatric renal cancer worldwide, originated from the embryonal nephric mesenchyme. However, epidemiological data on the association between LINC00673 polymorphisms and Wilms tumor risk are scant. This case–control study was conducted to investigate the potential role of the LINC00673 rs11655237 C>T polymorphism in the susceptibility to Wilms tumor.MethodsIn the present study, we conducted a genotyping analysis of LINC00673 rs11655237 C>T in 414 cases and 1199 controls recruited from five hospitals in China. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from multiple logistic regression models to determine the association of LINC00673 rs11655237 C>T polymorphism and Wilms tumor susceptibility.ResultsNo significant association between the LINC00673 rs11655237 C>T polymorphism and Wilms tumor risk was observed (CT versus CC: adjusted OR = 0.90, 95% CI = 0.71–1.15; TT versus CC: adjusted OR = 0.86, 95% CI = 0.50–1.49; TT/CT versus CC: adjusted OR = 0.90, 95% CI = 0.71–1.13; and TT versus CC/CT: adjusted OR = 0.89, 95% CI = 0.52–1.53). We also failed to make any remarkable findings for this genotype in the stratification analysis.ConclusionsIn summary, we failed to provide any evidence in favor of the significant susceptibility of rs11655237 C>T polymorphism in LINC00673 to Wilms tumor. These data could be useful for reinforcing our understanding of the potential contribution of LINC00673 rs11655237 C>T to Wilms tumor susceptibility.

show abstract

Investigation of association between LINC00673 rs11655237 C>T and Wilms tumor susceptibility

Cited by 5 publications

References 35 publications

Association between the LINC00673 rs11655237 C> T polymorphisms with cancer risk in the Chinese population: A meta-analysis

Association between the LINC00673 rs11655237 C> T polymorphisms with cancer risk in the Chinese population: A meta-analysis

The Significant Contribution of LINC00673 Rs11655237 C > T Polymorphism to Cancer Susceptibility in Chinese Population: A Meta-analysis of The Current Literature

LINC00673 rs11655237 C>T and susceptibility to Wilms tumor: A five‐center case–control study

Contact Info

Product

Resources

About