Investigation of association between the TRAF family genes and RA susceptibility

Abstract

These findings provide evidence for the association of an SNP upstream of a strong candidate RA susceptibility gene, TRAF5, in a large cohort of patients and controls. Further association and functional studies are required to investigate the role of this variant, or one in linkage disequilibrium with it, in RA disease causation.

Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjögren's syndrome

“…For example, the regulation of IRAK1 and IRAK2 by miR-146 and NF-B can be different in stressed human astroglial cells and in Alzheimer disease [26]. Therefore, the proof of any association between the deregulated expression of IRAK1 and TRAF6 genes in various autoimmune diseases needs carefulness, especially, if one still considers that various genetic polymorphisms can exist both in the IRAK1 [27] and TRAF6 [28,29] genes modifying the effects of miR-146a in different ways and at different extent. Therefore, we regard the increase in TRAF6 gene expression to be a more specific biomarker of Sjögren's syndrome than the increased expression of miR-146a or any alterations in the expression of IRAK genes.…”

Membrane-Bound Toll-Like Receptors are Overexpressed in Peripheral Blood and Synovial Fluid Mononuclear Cells of Enthesitis-Related Arthritis Category of Juvenile Idiopathic Arthritis (JIA–ERA) Patients and Lead to Secretion of Inflammatory Mediators

“…It may be due to feedback regulation due to inflammatory milieu, promoter region polymorphisms, or regulation by microRNAs. Indeed, polymorphism in TRAF5 gene shows a strong association with RA [30].…”

TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression

“…The expression levels of TRAF5 increase in patients suffering from inflammatory bowel disease, and there is a weak correlation between TRAF5 and endoscopic disease activity index in patients with ulcerative colitis (16). Also, TRAF5 has been identified as a strong candidate for the rheumatoid arthritis susceptibility gene in the British population (17), and it is involved in the development of acute anterior uveitis (18), according to genetic polymorphism analysis in Han Chinese. In addition, cardiac hypertrophy and fibrosis are aggravated in Traf Ϫ/Ϫ mice compared with wild-type mice, suggesting that TRAF5 is a protective factor for the disease (19).…”