Investigation of Asymmetric and Symmetric Dimethylarginine Levels after Iloprost Treatment in Patients with Buerger's Disease

Şenol, Sefa; Şenol, Arzu

doi:10.1016/j.ejvs.2016.12.017

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…In addition, ADMA inhibits NO and Şenol Iloprost and ADMA Levels 109 reduces vascular compliance, increase vascular resistance, and limit blood flow (7). It is shown that angiogenic growth factors stimulate NO release (24) and require NO in order to perform angiogenic functions (17,25,26). Jacobi et al (27) have demonstrated that the inhibition of ADMA has increased angioadaptation against ischemic and inflammatory stimulants in mice and angiogenesis and arteriogenesis has recovered.…”

Section: Discussionmentioning

confidence: 99%

Periferik Vasküler Hastalığın Tedavisinde İloprost’tun Nitrik Oksit, Asimetrik Dimetilarjinin ve Serotonin’e Etkisi

Şenol

2020

Ege Tıp Bilimleri Dergisi

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Section: Discussionmentioning

confidence: 99%

Periferik Vasküler Hastalığın Tedavisinde İloprost’tun Nitrik Oksit, Asimetrik Dimetilarjinin ve Serotonin’e Etkisi

Şenol

2020

Ege Tıp Bilimleri Dergisi

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“…Currently, there are studies being conducted to evaluate the efficacy of new drugs and certain procedures dependent on disease staging; surgical sympathectomies, mononuclear cell therapy, iloprost, etc. [5-7]. Despite these promising studies, for now, we are only able to offer our patients information and means of smoking cessation.…”

Section: Discussionmentioning

confidence: 99%

Thromboangiitis Obliterans: Changing Demographics for a Preventable Disease

Stefancik

2019

Cureus

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Thromboangiitis obliterans (TAO), otherwise known as Buerger's Disease, is a rare, small-vessel vasculitis strongly associated with cigarette smoking, that when left untreated can cause vessel destruction and necrosis of the distal extremities leading to amputation. The patient being presented is a 46-year-old Caucasian female who has been smoking since the age of fifteen and shows characteristics of TAO on angiography. The uniqueness of this case lies in the epidemiology; the typical TAO patient is a 20 to 40-year-old Asian male. However, over the last few decades, the typical patient population for TAO has been shifting. Our patient represents this changing demographics of TAO patients that include a greater percentage of women, non-Asian ethnicities, and the elderly. This patient represents an opportunity to follow the disease progression and learn more about the pathophysiology of TAO as it pertains to its shifting demographics.

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“…Unfortunately, we do not have comprehensive data on pre-screening medication, food intake or staging information of the participants for the study. Certain medications can affect the blood levels of distinct metabolites, as observed for ADMA and SDMA in patients [80]. Notably, the control population of the training cohort was somewhat younger.…”

Section: Limitations Of the Studymentioning

confidence: 95%

Changing Metabolic Patterns along the Colorectal Adenoma–Carcinoma Sequence

Tevini

Eder

Huber-Schönauer

et al. 2022

JCM

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Colorectal cancer (CRC) is a major public health burden and one of the leading causes of cancer-related deaths worldwide. Screening programs facilitate early diagnosis and can help to reduce poor outcomes. Serum metabolomics can extract vital molecular information that may increase the sensitivity and specificity of colonoscopy in combination with histopathological examination. The present study identifies serum metabolite patterns of treatment-naïve patients, diagnosed with either advanced adenoma (AA) or CRC in colonoscopy screenings, in the framework of the SAKKOPI (Salzburg Colon Cancer Prevention Initiative) program. We used a targeted flow injection analysis and liquid chromatography-tandem mass spectrometry metabolomics approach (FIA- and LC-MS/MS) to characterise the serum metabolomes of an initial screening cohort and two validation cohorts (in total 66 CRC, 76 AA and 93 controls). The lipidome was significantly perturbed, with a proportion of lipid species being downregulated in CRC patients, as compared to AA and controls. The predominant alterations observed were in the levels of lyso-lipids, glycerophosphocholines and acylcarnitines, but additionally, variations in the quantity of hydroxylated sphingolipids could be detected. Changed amino acid metabolism was restricted mainly to metabolites of the arginine/dimethylarginine/NO synthase pathway. The identified metabolic divergences observed in CRC set the foundation for mechanistic studies to characterise biochemical pathways that become deregulated during progression through the adenoma to carcinoma sequence and highlight the key importance of lipid metabolites. Biomarkers related to these pathways could improve the sensitivity and specificity of diagnosis, as well as the monitoring of therapies.

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Investigation of Asymmetric and Symmetric Dimethylarginine Levels after Iloprost Treatment in Patients with Buerger's Disease

Cited by 6 publications

References 18 publications

Periferik Vasküler Hastalığın Tedavisinde İloprost’tun Nitrik Oksit, Asimetrik Dimetilarjinin ve Serotonin’e Etkisi

Periferik Vasküler Hastalığın Tedavisinde İloprost’tun Nitrik Oksit, Asimetrik Dimetilarjinin ve Serotonin’e Etkisi

Thromboangiitis Obliterans: Changing Demographics for a Preventable Disease

Changing Metabolic Patterns along the Colorectal Adenoma–Carcinoma Sequence

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