Wedeveloped an adaptive forced-choice method whereby reference and test presentations were alternated in order to minimize effects from variables such as subject attention level. In our demonstration example of an X-rayfluoroscopy perception study, we measured detectability of low-contrast objects in noisy image sequences and determined X-raydose levels for equivalent detectability of identical contrasts for a new test acquisition method (fluoroscopy at 15 acq/sec) as compared with a reference (conventional fluoroscopy at 30acq/sec). In preliminary experiments, we found a dose savings with the test method. We derived parameter uncertainties for the adaptive procedure and demonstrated their applicability with Monte Carlo simulations. Repeated experiments on a single subject demonstrated reduced standard errors due to the reduction of day-to-day variations. It is believed that the method can be applied in a variety of situations in which one needs to compare perception measurements.We have developed a new experimental method that addresses issues in human perception studies. First, a subject's response can vary due to fatigue, a lapse in attention, or possible physiological changes. Kahneman (1973) discussed the importance of attention in perception experiments, indicating that attention may affect the sensory mechanism as well as the decision mechanism. Taylor (1967) observed variation in performance from one day to the next, and others (Hall, 1981;Madigan & Williams, 1987) reported variations within single experiments. This variation complicates comparison of results. For example, in our experiments in medical X-ray fluoroscopy, we compared new test acquisition methods with an established reference technique. Some of the effects that we wished to measure are comparable to day-to-day variations, and our solution was to alternate reference and test presentations over a time scale of seconds and obtain responses under identical conditions. Second, variability between subjects also presents a dilemma. For an independent variable such as image contrast, many trial-and-error presentations are required to arrive at display conditions that match the floor and ceiling responses of all subjects. This problem is well known, and adaptive techniques can solve the problem (