Investigation of biological accumulation and eco-genotoxicity of bismuth oxide nanoparticle in fresh water snail Lymnaea luteola

Al-Abdan, Monera A.; Bin-Jumah, May; Ali, Daoud; Alarifi, Saud

doi:10.1016/j.jksus.2021.101355

Cited by 14 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, SOD deficiency may be related to the damage of the cells due to the treatment stated by Ighodaro and Akinloye ( 2018 ), which states that aging and cell death decline the level of SODs. On the contrary, Al-Abdan et al ( 2021 ) found that sublethal concentrations of Bi 2 O3NPs significantly elevated SOD after 1, 3, and 7 days of exposure.…”

Section: Discussionmentioning

confidence: 93%

Potential toxic effects of titanium oxide (TiO2) nanoparticles on the biological, biochemical, and histological aspects of the land snail Helix aspersa

Abdel-Azeem

Osman

Mohamed

2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Nanotechnology has come a long way in our lives. However, it maintains some negative effects on the environment. This study aims to use the land snail Helix aspersa as a bioindicator. Titanium dioxide nanoparticles (TiO2NPs) had been used at 70 and 140 µg/L for two weeks by the spraying method. The oxidative biomarkers, condition index (CI), DNA damage, hemocyte count, and phagocytic activity were estimated. The toxicity of TiO2NPs was determined (LC50 = 544 µg/L). The exposure to TiO2NPs caused a significant reduction of the activities of superoxide dismutase (SOD) and catalase (CAT) in the digestive gland of Helix aspersa (the activity of CAT was 3.4 ± 0.1 (P = 0.001), SOD was 11 ± 1 (P = 0.0002) at concentration 140 µg/L after two weeks). The activity of glutathione peroxidase (GPX) was (1.13 ± 0.01 µ/mg protein at 140 µg/L compared with controls (5.47 ± 0.01 µ/mg protein). The treatment caused DNA damage in the hemocytes (tail DNA % = 8.66 ± 0.02 and tail moment = 52.99 ± 0 at140 µg/L (P = 0.002)). In the digestive gland, both tail DNA % and tail moment increased (tail moment = 78.38 ± 0.08 compared with control = 2.29 ± 0.09 (P = 0.0001)). The total count of hemocytes significantly decreased after two weeks (the average number was 71 ± 1.5 compared with controls 79 ± 1.1 at 140 µg/L). Furthermore, TiO2NPs caused histological alterations in the digestive gland of Helix aspersa. It can be concluded that the Helix aspersa can be used as environmental pollution bioindicator. A comprehensive evaluation of toxic effects induced by TiO2NPs in vivo assays must be investigated.

show abstract

Section: Discussionmentioning

confidence: 93%

Potential toxic effects of titanium oxide (TiO2) nanoparticles on the biological, biochemical, and histological aspects of the land snail Helix aspersa

Abdel-Azeem

Osman

Mohamed

2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…However, along with other biochemical parameters such as glucose (105 ± 1.1 vs. 115 ± 0.5 mg/dL), AST (55.8 ± 0.3 vs. 57.4 ± 0.2 μg/L), ALT (28.6 ± 0.4 vs. 30.8 ± 0.5 μg/L) and uric acid (12.7 ± 0.04a 13 ± 0.1 mg/dL), total proteins (5.6 ± 0.1 vs. 6.4 ± 0.1 g/dL) also increased significantly ( p < 0.05) in Nile tilapia ( Oreochromis niloticus ) with the treatment of both CuSO 4 (15 mg/L) and CuO-NP ( 24 ). Increased total proteins in Nile tilapia with the treatment of CuSO 4 ( 24 ) could be the reason that during exposure to Cu, fish may require higher protein concentration to meet the increased demand for repairing tissue and enhance the immunological response ( 20 ). Similarly, Atta et al ( 63 ) reported that birds supplemented with excessive CuSO 4 revealed an increase in ALP, ALT, and AST activities while reducing albumin, globulin levels, and total serum protein are consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

“…(24) could be the reason that during exposure to Cu, fish may require higher protein concentration to meet the increased demand for repairing tissue and enhance the immunological response (20) the functional damage to the liver (31), and excessive loss of protein caused by degenerated glomerulus or could be explained due to the oxidative stress of copper on the liver and kidney tissue (64). There is also the possibility that the release of intracellular enzymes as a result of hepatic degeneration and necrosis caused by CuSO 4 could lead to lipid peroxidation, which resultantly ends in hypoproteinemia (65).…”

Section: Discussionmentioning

confidence: 99%

“…Over the last years, aquatic contamination has become a great concern for marine life and public health ( 17 – 19 ). Anthropogenic activities and accidental industrial waste discharge have become major causes of aquatic pollution in freshwater ( 20 ). Pollution due to heavy metals occur in the aquatic ecosystem due to agricultural discharge, geological weathering, municipal, direct air deposition, and other industrial waste products ( 21 – 24 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Copper sulfate induces clinico-hematological, oxidative stress, serum biochemical and histopathological changes in freshwater fish rohu (Labeo rohita)

Naz

Hussain²,

Guangbin³

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

Despite being an essential trace element for numerous metabolic processes and micronutrients, copper (Cu) has induced adverse effects on the environment and public health due to its continuous and widespread use for the last several decades. The current study assessed the hematological and histopathological alterations in the freshwater fish (Labeo rohita) exposed to graded concentrations of copper sulfate. For this purpose, L. rohita fish (n = 72), weighing ~200–215 g, were randomly divided into four experimental groups and then exposed to acute doses of CuSO4, i.e., control, 0.28, 0.42, and 0.56 μgL−1. For comparative analysis of hematological and biochemical changes, blood/serum samples were obtained on 12, 24, and 36 days. Overall, the body weight of fish decreased with the time and dose of CuSO4; as the dose increases, body weight decreases. Dose and time-dependent results were observed in other parameters also. Results showed a significant increase in leukocytes, whereas red blood cells count, Hb, and Hct were significantly reduced in treated groups compared to the control. The mean corpuscular hemoglobin (MHC) and mean corpuscular hemoglobin concentration (MCHC) showed a non-significant decrease in treated groups compared to the control group. Serum biochemical parameters, including total proteins, albumin, and globulin, decreased significantly (p < 0.05). At the same time, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glucose, and cholesterol were significantly (p < 0.05) increased in the treated groups compared to the control group. Significantly (p < 0.05) increased levels of lipid peroxidation while decreased values of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (RGSH) in the blood of fish were recorded. Histopathological examination of fish gills, liver, and kidneys showed inflammation and degenerative changes due to CuSO4 exposure. In the brain tissue, degenerative changes like neuron necrosis, intracellular edema, cytoplasmic vacuolization, and congestion were observed. In conclusion, the study indicates that exposure to copper sulfate, even in smaller concentrations, can cause adverse hematological and histopathological changes in L. rohita fish.

show abstract

“…Oxidative stress is believed to be associated with the advancement of depression, which was reported with abnormal changes in plenty of literatures [35,36]. Besides, the high sensitivity of the brain to oxidative stress is mainly due to the relative lack of antioxidant enzymes, such as SOD and GPx, and high level LDH in tissues [37,38]. For example, Roslan et al showed that Quercetin ameliorated oxidative stress through inhibiting SOD, CAT, and GPx [39].…”

Section: Discussionmentioning

confidence: 99%

A Famous Chinese Medicine Formula: Yinhuo Decoction Antagonizes the Damage of Corticosterone to PC12 Cells and Improves Depression by Regulating the SIRT1/PGC-1α Pathway

Xing

Xia

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

The study aimed to explore the antidepressant effect of Yinhuo Decoction and further to explore its underlying molecular mechanism acting on depressant. Here, high-performance liquid chromatography (HPLC) analysis was used to the composition analysis. Postmenopausal depression (PMD) model and corticosterone (CORT)-induced cell model were constructed. Adrenal coefficient and hematoxylin and eosin staining were applied to assess changes in the adrenal glands. MTT staining, Hoechst 33342 staining, and JC-1 fluorescence staining were used to detect the PC12 activity and apoptosis. CORT and oxidative stress indicators were measured using commercial kits. Western blot and immunohistochemical were used to detect the protein expression of GCR. In addition, genes related to SIRT1/PGC-1α pathway were also tested. In PMD model mice, Yinhuo Decoction evidently increased adrenal coefficient and relieved adrenal lesions. Meanwhile, we observed that Yinhuo Decoction reduced the CORT and GCR levels. In CORT-treated PC12 cells, Yinhuo Decoction remarkably reduced cytotoxicity and apoptosis. Besides, Yinhuo Decoction attenuated the oxidative stress response. Mechanically, we confirmed that Yinhuo Decoction reduced CORT-induced PC12 damage by regulating SIRT1/PGC-1α pathway. Thus, we concluded that Yinhuo Decoction antagonized CORT-induced injury in PC12 cells and improved depression in PMD mice. This provided a new direction for the treatment of depression.

show abstract

Investigation of biological accumulation and eco-genotoxicity of bismuth oxide nanoparticle in fresh water snail Lymnaea luteola

Cited by 14 publications

References 18 publications

Potential toxic effects of titanium oxide (TiO2) nanoparticles on the biological, biochemical, and histological aspects of the land snail Helix aspersa

Potential toxic effects of titanium oxide (TiO2) nanoparticles on the biological, biochemical, and histological aspects of the land snail Helix aspersa

Copper sulfate induces clinico-hematological, oxidative stress, serum biochemical and histopathological changes in freshwater fish rohu (Labeo rohita)

A Famous Chinese Medicine Formula: Yinhuo Decoction Antagonizes the Damage of Corticosterone to PC12 Cells and Improves Depression by Regulating the SIRT1/PGC-1α Pathway

Contact Info

Product

Resources

About