Investigation of Blood Hemolysis Study in Rotary Blood Pump between Continuous Flow and Pulsatile Flow

Rungsirikunnan, Chitsanupong; Mondee, Kamonwan; Gesprasert, Goragoch; Naiyanetr, Phornphop

doi:10.1109/bmeicon.2018.8609953

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Therefore, the hemocompatibility test of the VAD in the MCL is necessary. Numerous researchers chose MCLs with constant flow to perform the VAD hemocompatibility test, such as the hemolytic ( Cahill and Kolff, 1959 ; Takami et al, 1996 ; Rungsirikunnan et al, 2018 ) and thrombotic ( Linneweber et al, 2002 ; Linneweber et al, 2008 ; Maruyama et al, 2009 ; Dassanayaka et al, 2013 ; Zayat et al, 2019 ) investigations. For instance, a test loop was recommended by American Society of Testing Materials (ASTM) to conduct the in vitro hemolysis test on continuous VAD ( ASTM F1841-19, 2019 ).…”

Section: Applications Of MCL For Cadmentioning

confidence: 99%

Mock circulatory loop applications for testing cardiovascular assist devices and in vitro studies

Gao

Wan³

et al. 2023

Front. Physiol.

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The mock circulatory loop (MCL) is an in vitro experimental system that can provide continuous pulsatile flows and simulate different physiological or pathological parameters of the human circulation system. It is of great significance for testing cardiovascular assist device (CAD), which is a type of clinical instrument used to treat cardiovascular disease and alleviate the dilemma of insufficient donor hearts. The MCL installed with different types of CADs can simulate specific conditions of clinical surgery for evaluating the effectiveness and reliability of those CADs under the repeated performance tests and reliability tests. Also, patient-specific cardiovascular models can be employed in the circulation of MCL for targeted pathological study associated with hemodynamics. Therefore, The MCL system has various combinations of different functional units according to its richful applications, which are comprehensively reviewed in the current work. Four types of CADs including prosthetic heart valve (PHV), ventricular assist device (VAD), total artificial heart (TAH) and intra-aortic balloon pump (IABP) applied in MCL experiments are documented and compared in detail. Moreover, MCLs with more complicated structures for achieving advanced functions are further introduced, such as MCL for the pediatric application, MCL with anatomical phantoms and MCL synchronizing multiple circulation systems. By reviewing the constructions and functions of available MCLs, the features of MCLs for different applications are summarized, and directions of developing the MCLs are suggested.

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