Investigation of blood perfusion and metabolic activity of brain tumours in adults by using 99mTc-methoxyisobutylisonitrile

Petrović, Nikola; Grujičić, Danica; Artiko, Vera; Šobić-Šaranović, Dragana; Gajić, Milan; Jaksic, E.; Grajic, Mirko; Antonovic, Olga; Petrović, Miloš; Obradović, Vladimir

doi:10.1097/mnm.0b013e32833ea6cc

Cited by 7 publications

(4 citation statements)

References 58 publications

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“…No study has examined the uptake mechanism of Tc-99m MIBI in parathyroid carcinoma. Related studies suggest that intense uptake and delayed retention may be caused by high mitochondrial content, increased perfusion, or increased metabolic activity [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Differential Findings of Tc-99m Sestamibi Dual-Phase Parathyroid Scintigraphy Between Benign and Malignant Parathyroid Lesions in Patients with Primary Hyperparathyroidism

Cheon

Choi

Chung

et al. 2011

Nucl Med Mol Imaging

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Section: Discussionmentioning

confidence: 99%

Differential Findings of Tc-99m Sestamibi Dual-Phase Parathyroid Scintigraphy Between Benign and Malignant Parathyroid Lesions in Patients with Primary Hyperparathyroidism

Cheon

Choi

Chung

et al. 2011

Nucl Med Mol Imaging

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“…Although encountering tumor imaging using Tc-99m MIBI is rare, nuclear physicians should be aware that tumors rich in mitochondria, such as thyroid carcinoma, lymphoma, and brain tumors, could exhibit high uptake of Tc-99m MIBI. [12][13][14] Although there have been reports on patients with concurrent parathyroid adenoma and thyroid carcinoma, [15,16] distinguishing the 2 based on imaging remains challenging. We misdiagnosed thyroid carcinoma as a parathyroid adenoma located within the thyroid gland and missed the presence of a small parathyroid adenoma on the contralateral side.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Incidentally detected follicular thyroid carcinoma mimicking parathyroid adenoma on Tc-99m MIBI scan: A case report

Han,

Jeong,

Lee

et al. 2024

Medicine

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Rationale: Primary hyperparathyroidism, though relatively prevalent among endocrine disorders, affecting 1% of the general population, often presents diagnostic challenges. Given its potential to precipitate severe complications including nephrolithiasis and fractures, timely diagnosis, and effective management are crucial. Patient concerns: A 38-year-old woman with hypercalcemia was referred to the Department of Nuclear Medicine for a Tc-99m MIBI scan. Diagnoses: Tc-99m MIBI scan showed focal increased uptake in the left thyroid gland area, initially suggesting a parathyroid adenoma. Further examination using SPECT/CT revealed a nodular lesion within the left thyroid gland showing high Tc-99m MIBI uptake. Interventions: Left thyroid lumpectomy confirmed the lesion as follicular thyroid carcinoma. On the second Tc-99m MIBI scan conducted after total thyroidectomy, a parathyroid adenoma was eventually detected in the right lower area, enabling the subsequent appropriate treatment, a right lower parathyroidectomy. Outcomes: Thirteen days after the parathyroidectomy, serum levels of total calcium and parathyroid hormone returned to normal. Furthermore, bone mineral density evaluated using DEXA remained within the expected range for her age even after 14 months. Lessons: When interpreting the Tc-99m MIBI scan, it is essential to keep in mind that various tumors rich in mitochondria, such as thyroid carcinoma, could show a high uptake of Tc-99m MIBI.

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“…99m Tc-MIBI uptake is related to tissue perfusion and normal cell membrane and mitochondrial activity. It has been described by Petrovic et al [21] that meningiomas exhibit high perfusion index but low retention index. This phenomenon was attributed to a relatively weak fixation of the radiopharmaceutical in benign meningioma cells.…”

Section: Spect Radiopharmaceuticalsmentioning

confidence: 99%

SPECT and PET Imaging of Meningiomas

Valotassiou

Leondi

Angelidis

et al. 2012

The Scientific World Journal

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Meningiomas arise from the meningothelial cells of the arachnoid membranes. They are the most common primary intracranial neoplasms and represent about 20% of all intracranial tumors. They are usually diagnosed after the third decade of life and they are more frequent in women than in men. According to the World Health Organization (WHO) criteria, meningiomas can be classified into grade I meningiomas, which are benign, grade II (atypical) and grade III (anaplastic) meningiomas, which have a much more aggressive clinical behaviour. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are routinely used in the diagnostic workup of patients with meningiomas. Molecular Nuclear Medicine Imaging with Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) could provide complementary information to CT and MRI. Various SPECT and PET tracers may provide information about cellular processes and biological characteristics of meningiomas. Therefore, SPECT and PET imaging could be used for the preoperative noninvasive diagnosis and differential diagnosis of meningiomas, prediction of tumor grade and tumor recurrence, response to treatment, target volume delineation for radiation therapy planning, and distinction between residual or recurrent tumour from scar tissue.

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Investigation of blood perfusion and metabolic activity of brain tumours in adults by using 99mTc-methoxyisobutylisonitrile

Cited by 7 publications

References 58 publications

Differential Findings of Tc-99m Sestamibi Dual-Phase Parathyroid Scintigraphy Between Benign and Malignant Parathyroid Lesions in Patients with Primary Hyperparathyroidism

Differential Findings of Tc-99m Sestamibi Dual-Phase Parathyroid Scintigraphy Between Benign and Malignant Parathyroid Lesions in Patients with Primary Hyperparathyroidism

Incidentally detected follicular thyroid carcinoma mimicking parathyroid adenoma on Tc-99m MIBI scan: A case report

SPECT and PET Imaging of Meningiomas

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