Investigation of chirp coded excitation with dualfrequency transmit for ultrasonic harmonic contrast detection

Shen, Che-Chou; Chiu, Yi-Yuan

doi:10.1109/ultsym.2009.5441642

Cited by 1 publication

(2 citation statements)

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“…23 Shen and colleagues incorporated chirp-coding into dual frequency difference excitation imaging to excite UCAs close to their resonance frequency. 24 They reported improvements in the SNR, at the expense of a reduced agent-to-tissue contrast. It was also demonstrated that chirp-coded excitation improved the SNR of 3f 0 transmit phasing techniques; 25 however, the agent-to-tissue contrast was reduced.…”

Section: Introductionmentioning

confidence: 99%

“…Chirp-coded excitation is one such technique that has been widely investigated for contrast-enhanced ultrasound imaging. 14,[18][19][20][21][22][23][24][25][26][27] In a theoretical study, Barlow and colleagues reported an analytical solution to the Keller-Herring model, to predict the response of microbubbles to chirp-coded excitation. 18 A classical perturbative analysis was employed 28 to gain insight into the impact of excitation parameters on the nonlinear response.…”

Section: Introductionmentioning

confidence: 99%

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The response of phospholipid-encapsulated microbubbles to chirp-coded excitation: Implications for high-frequency nonlinear imaging

Shekhar

Doyley

2013

The Journal of the Acoustical Society of America

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The current excitation strategy for harmonic and subharmonic imaging (HI and SHI) uses short sinebursts. However, alternate pulsing strategies may be useful for enhancing nonlinear emissions from ultrasound contrast agents. The goal of this study was to corroborate the hypothesis that chirp-coded excitation can improve the performance of high-frequency HI and SHI. A secondary goal was to understand the mechanisms that govern the response of ultrasound contrast agents to chirp-coded and sine-burst excitation schemes. Numerical simulations and acoustic measurements were conducted to evaluate the response of a commercial contrast agent (Targestar-P V R ) to chirp-coded and sine-burst excitation (10 MHz frequency, peak pressures 290 kPa). The results of the acoustic measurements revealed an improvement in signal-to-noise ratio by 4 to 14 dB, and a two-to threefold reduction in the subharmonic threshold with chirp-coded excitation. Simulations conducted with the Marmottant model suggest that an increase in expansion-dominated radial excursion of microbubbles was the mechanism responsible for the stronger nonlinear response. Additionally, chirp-coded excitation detected the nonlinear response for a wider range of agent concentrations than sine-bursts. Therefore, chirp-coded excitation could be a viable approach for enhancing the performance of HI and SHI.

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Section: Introductionmentioning

confidence: 99%