Investigation of Chitosan Film Degradation in Tissue Engineering Applications

Kadhim, Ishraq Abd Ulrazzaq; Ameer, Zuhair Jabbar Abdul; Alzubaidi, Aseel B

doi:10.1088/1757-899x/671/1/012060

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…Aside from that, the alkyl group at 2925 cm −1 and peaks at 1323 cm −1 and 1085 cm −1 were observed due to the -O-H in-plane vibrations and -C-O out-of-plane bonding, respectively, along with shifting in the -N-H bending vibration, from 1500 cm −1 of amide II to 2350 cm −1 in the CS/PVA blended film illuminating the interaction between the -O-H and -N-H groups of CS with the -O-H group of PVA [7]. As shown in Figure 2, the interactions between the chitosan and PVA in the mix, namely the hydrophobic side chain aggregation and intermolecular and intramolecular hydrogen bonding, are responsible for the improved characteristics [19].…”

Section: Fourier-transform Infrared (Ftir) Analysismentioning

confidence: 93%

Optimization of mechanical and biocompatible properties of ZnOs-fiber membranes

Jomaa,

Hussein,

Dawood

2024

ETJ

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Bio-composite materials were fabricated for wound healing in three concentrations.• Biodegradable polymers were used to create electrospun fibers. • A blend of polyvinyl alcohol and chitosan, incorporated with nanoparticles, was used to modify mechanical properties.This study uses electro-spinning techniques to create a poly(vinyl alcohol)chitosan-zinc oxide nanoparticles (PVA+CS)+ZnO NPs system in three concentrations of ZnO for application as composite nanofibers for wound treatment applications and Employing the Taguchi technique to optimize the mechanical characteristics via a four-level experimental design process (L16).Numerous techniques have been utilized to characterize the nanofibrous scaffolds: contact angle measurement, cytotoxicity testing, proliferation testing, evaluation of antimicrobial activity, Fourier Transform Infrared Spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersion X-ray Spectroscopy (EDX), and a comparative experimental study involving the determination of hardness using the Nanoindentation method for (PVA+CS)+ZnO. The ideal combination for adding ZnO as nanoparticles was found to be (PVA+CS)+0.6 ZnO, with a flow rate of 0.5 mL/hr, an applied voltage of 18 kV, and a needle tip-to-collector distance of 15 cm (position). This resulted in the smallest fiber diameter (48 nm) with a smooth and uniform distribution. As a consequence, (PVA+CS)+ZnO can be regarded as non-toxic in accordance with the criteria. The methyl thiazole tetrazolium (MTT) assay was used to evaluate the cell viability of L929 (cell cultures for skin). It significantly affects cell viability, achieving 50% in less than 24 hours, which means cell growth through 24 hours is necessary for embryonic development, tissue repair, and regulation of cell division in case of wound healing. Exhibiting findings of inhibition zone diameter in antibacterial activity test exceeding 20 mm. According to the results, (PVA+CS)+0.6 ZnO's hydrophilic properties showed a well-connected porous structure and made it easier for nutrients and oxygen to be exchanged, encouraging cellular activity. After evaluating the mechanical characteristics of each specimen, the main determinants of these characteristics are determined using a Taguchi orthogonal array L16 design. The results of this study suggest that (PVA+CS)+0.6 ZnO could be a good biomedical material for skin tissue engineering applications.

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Section: Fourier-transform Infrared (Ftir) Analysismentioning

confidence: 93%

Optimization of mechanical and biocompatible properties of ZnOs-fiber membranes

Jomaa,

Hussein,

Dawood

2024

ETJ

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“…For the contact angle test, a drop of water at a volume of 4 μl was poured on the surface of the sample with at least three repetitions, while the images of the water droplet were recorded on the sample surface. The degradability of electrospinning scaffolds was measured according to the standard protocol (ASTM F1635), 17 while, the dry electrospinning samples were cut into 10 × 10 mm dimensions and were weighed to the nearest four decimal places (− W 0 ). Each sample was placed in falcons containing 20 ml of PBS solution (pH = 7.4) and the falcons were placed in an incubator at 37°C and replaced with a new solution every 4 days.…”

Section: Methodsmentioning

confidence: 99%

Characterization of sodium carboxymethyl cellulose/calcium alginate scaffold loaded with curcumin in skin tissue engineering

Rezaei

Nemati

Mehrabani

et al. 2022

J of Applied Polymer Sci

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Applying biological macromolecule like curcumin (CUC) has gained considerable attention for the anti-inflammatory, antioxidant, antimicrobial and antitumor properties. Therefore, this study was carried out to characterize carboxymethylcellulose/ calcium alginate (CMC/CA) scaffold loaded with CUC in skin tissue engineering. To observe the structural, mechanical, degradability, biological and antibacterial effect of CUC, it was loaded in a cellulose-based electrospinning scaffold of sodium CMC (SCMC) with CA. The addition of CUC increased the fiber diameter to 504 ± 83, and 522 ± 25 nm in 3% and 5% of CUC concentrations, respectively. The elasticity of the scaffold was enhanced, while the scaffold strength was decreased slightly. The inhibitory zone in the scaffold containing CUC denoted to its antibacterial properties. In addition, the cell viability, proliferation and attachment to the electrospun scaffolds were increased. Utilization of CUC-loaded materials can play an important role in anti-bacterial performance of the scaffold. Although mechanical properties of SCMC may slightly decreased during the loading process, but the morphological, chemical, and biological properties were improved. It seems that applying electrospinning technique and CUC incorporation in fabricated scaffolds can be a promising choice in skin tissue engineering when antibacterial properties are also targeted in conjunction with the tensile strength.

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“…Biodegradable polymers can be considered biomaterials formed by renewable or synthetic source [3]. Many bio-degradable polymers utilized to create a scaffolds for applications of tissue engineering [TE] [4]. The aim of producing of scaffolds is to simulate the natural tissue and regenerative of the cells.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of Alginate -Graphene Oxide Film for Tissue Engineering Applications

Kadhim

2021

KEM

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The present paper indicates promising potential of Sodium Alginate) Alg)/Graphene oxide (Go) films in fields bone tissue engineering (TE). The Sodium Alginate (Alg)/Graphene oxide (Go) films, were fabricated via (solvent casting method). The interaction of Sodium Alginate (Alg) with Graphene oxide (Go) via hydrogen bonding was confirmed by FTIR analysis. The swelling degree of Sodium Alginate (Alg)/Graphene oxid (Go) films was also studied. Furthermore, the biocompatibility of Sodium Alginate (Alg)/Graphene oxide (Go) films disclosed its non-cytotoxic effect on the cell lines (MG-63) in-vitro test, the viability of cell lines on the films, and hence its appropriateness as potent biomaterial for tissue engineering.

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Investigation of Chitosan Film Degradation in Tissue Engineering Applications

Cited by 5 publications

References 13 publications

Optimization of mechanical and biocompatible properties of ZnOs-fiber membranes

Optimization of mechanical and biocompatible properties of ZnOs-fiber membranes

Characterization of sodium carboxymethyl cellulose/calcium alginate scaffold loaded with curcumin in skin tissue engineering

Biocompatibility of Alginate -Graphene Oxide Film for Tissue Engineering Applications

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