Investigation of circular RNA transcriptome in obesity-related endometrial cancer

Takenaka, Konii; Olzomer, Ellen M.; Hoehn, Kyle L.; Curry‐Hyde, Ashton; Chen, Bei Jun; Farrell, Rhonda; Byrne, Frances L.; Janitz, Michael

doi:10.1016/j.gene.2022.147125

Cited by 6 publications

(8 citation statements)

References 38 publications

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“…Evidence suggests that downregulated hsa_circ_000839 in patients with BC exhibits a negative correlation with BMI, but the underlying mechanism is still unclear 190 . A transcriptome study of circRNAs was conducted, focusing on obese and postmenopausal patients with EC and revealed the presence of 174 differentially expressed circRNA in EC tissues compared with adjacent normal tissues 191 . Nonetheless, additional functional research is required to determine the circRNAs that can offer diagnostic and prognostic assistance in relation to obesity‐related EC.…”

Section: Ncrnas In Obesity‐associated Diseasesmentioning

confidence: 99%

“…190 A transcriptome study of circRNAs was conducted, focusing on obese and postmenopausal patients with EC and revealed the presence of 174 differentially expressed circRNA in EC tissues compared with adjacent normal tissues. 191 Nonetheless, additional functional research is required to determine the circRNAs that can offer diagnostic and prognostic assistance in relation to obesityrelated EC. The plasma of TNBC patients with high BFR showed increased expression of exo-cirCRIM1 derived from adipocytes.…”

Section: Circrnas In Obesity-associated Diseasesmentioning

confidence: 99%

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Epigenetic modifications in obesity‐associated diseases

Long,

Mao,

Liu

et al. 2024

MedComm

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The global prevalence of obesity has reached epidemic levels, significantly elevating the susceptibility to various cardiometabolic conditions and certain types of cancer. In addition to causing metabolic abnormalities such as insulin resistance (IR), elevated blood glucose and lipids, and ectopic fat deposition, obesity can also damage pancreatic islet cells, endothelial cells, and cardiomyocytes through chronic inflammation, and even promote the development of a microenvironment conducive to cancer initiation. Improper dietary habits and lack of physical exercise are important behavioral factors that increase the risk of obesity, which can affect gene expression through epigenetic modifications. Epigenetic alterations can occur in early stage of obesity, some of which are reversible, while others persist over time and lead to obesity‐related complications. Therefore, the dynamic adjustability of epigenetic modifications can be leveraged to reverse the development of obesity‐associated diseases through behavioral interventions, drugs, and bariatric surgery. This review provides a comprehensive summary of the impact of epigenetic regulation on the initiation and development of obesity‐associated cancers, type 2 diabetes, and cardiovascular diseases, establishing a theoretical basis for prevention, diagnosis, and treatment of these conditions.

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Section: Ncrnas In Obesity‐associated Diseasesmentioning

confidence: 99%

Section: Circrnas In Obesity-associated Diseasesmentioning

confidence: 99%

Epigenetic modifications in obesity‐associated diseases

Long,

Mao,

Liu

et al. 2024

MedComm

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“…Tissue hypoxia upregulates HIF-mediated transcription and has pleiotropic sequelae related to adverse prognosis in the context of endometrial cancer (as well as other cancer types), including increased cell proliferation; stemness, epithelial-mesenchymal transition (EMT) and aggressive phenotype; metabolic adaptation and drug efflux resulting in resistance to chemotherapy; vasculogenesis (vasculogenic mimicry) and angiogenesis (vascular remodeling); and finally invasive and metastatic potential 91 - 93 . The role of miRNA has also started to be investigated in the context of obesity-related endometrial cancer and relevant research is still ongoing 94 . In brief, the etiopathogenetic similarities to obesity-related breast cancer are obvious.…”

Section: Endometrial Cancermentioning

confidence: 99%

The Effectiveness of Metabolic Bariatric Surgery in Preventing Gynecologic Cancer - from Pathophysiology to Clinical Outcomes

Machairiotis,

Pantelis,

Potiris

et al. 2024

J. Cancer

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Obesity and cancer represent two pandemics of current civilization, the progression of which has followed parallel trajectories. To time, thirteen types of malignancies have been recognized as obesity-related cancers, including breast (in postmenopausal women), endometrial, and ovarian cancer. Pathophysiologic mechanisms that connect the two entities include insulin resistance, adipokine imbalance, increased peripheral aromatization and estrogen levels, tissue hypoxia, and disrupted immunity in the cellular milieu. Beyond the connection of obesity to carcinogenesis at a molecular and cellular level, clinicians should always be cognizant of the fact that obesity might have secondary impacts on the diagnosis and treatment of gynecologic cancer, including limited access to effective screening programs, resistance to chemotherapy and targeted therapies, persisting lymphedema, etc. Metabolic bariatric surgery represents an attractive intervention not only for decreasing the risk of carcinogenesis in high-risk women living with obesity but most importantly as a measure to improve disease-specific and overall survival in patients with diagnosed obesity-related gynecologic malignancies. The present narrative review summarizes current evidence on the underlying pathophysiologic mechanisms, the clinical data, and the potential applications of metabolic bariatric surgery in all types of gynecologic cancer, including breast, endometrial, ovarian, cervical, vulvar, and vaginal.

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“…Its incidence has been increasing globally, with 417,000 new cases and 97,000 deaths in 2020 [ 1 , 2 ]. Risk factors of EC included obesity, early menarche, late menopause, nulliparity, and age [ 3 , 4 ]. The increase in the incidence of EC [ 1 , 2 ] may be partly attributed to the rising trend of obesity [ 5 ] and the increase in the aging population [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…To help guide treatment, the traditional Bokhman’s dualistic model [ 7 ] stratifies EC patients into type I and type II based on clinical and histopathological factors (such as cell types and tumor grading). Type I EC is typically low-grade and hormone-sensitive, and has a favorable prognosis [ 3 , 4 ]. In contrast, type II EC is high-grade, typically negative in hormone receptors, and has a poorer prognosis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Improved Progression-Free Survival Associated with Tumor-Infiltrating Lymphocytes in High-Grade Endometrial Cancer

Fan

Hsu

Sun

et al. 2023

JCM

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Tumor-infiltrating lymphocytes (TILs) have emerged as a prognostic marker in endometrial cancer (EC). However, the role of TILs in EC with distinct histology grades and molecular types (such as mismatch repair [MMR] deficiency) has not yet been made clear. We retrospectively included 237 patients with primary EC who underwent a standard staging operation of laparoscopic or laparotomy total hysterectomy and bilateral salpingo-oophorectomy for analyses. An independent pathologist who was blind to the study patients’ information reviewed the pathologic slides to assess TILs according to the method introduced by the International Immuno-Oncology Biomarkers Working Group in 2017. The outcomes of interest included both progression-free survival (PFS) and overall survival (OS). The Kaplan–Meier method was used to determine the curves of PFS and OS according to TILs, and also in the relevant subgroups (low-grade vs. high-grade, MMR-proficient vs. MMR-deficient). After a median follow-up duration of 1.82 years, 18 patients had experienced either disease progression or death. Overall, TILs (+) were not associated with PFS or OS. We did observe, however, that TILs (+) were associated with a better PFS (p = 0.045) in patients with high-grade EC, but not in those with low-grade tumors (p = 0.733). The effect of TILs on PFS was not observed in patients with MMR-proficient (p = 0.347) or MMR-deficient (p = 0.168) EC. TILs were associated with a better PFS in patients with high-grade EC. Our results suggest that TILs may be a potential prognostic marker in these patients.

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Investigation of circular RNA transcriptome in obesity-related endometrial cancer

Cited by 6 publications

References 38 publications

Epigenetic modifications in obesity‐associated diseases

Epigenetic modifications in obesity‐associated diseases

The Effectiveness of Metabolic Bariatric Surgery in Preventing Gynecologic Cancer - from Pathophysiology to Clinical Outcomes

Improved Progression-Free Survival Associated with Tumor-Infiltrating Lymphocytes in High-Grade Endometrial Cancer

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