Investigation of Classical Pulse Sequences for Contrast-Enhanced Ultrasound Imaging With a cMUT Probe

Fouan, Damien; Bouakaz, Ayache

doi:10.1109/tuffc.2016.2567641

Cited by 21 publications

(17 citation statements)

References 50 publications

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“…8,9 Moreover, the PD mode was very sensitive to the vibrations we applied, limiting the detection of microcirculation. This microvascular flow setup could also be used for dynamic contrast-enhanced ultrasound modes to develop new imaging modalities, 39,40 new transducers 41 or new quantification methods. 42…”

Section: Discussionmentioning

confidence: 99%

A Novel Microflow Phantom Dedicated to Ultrasound Microvascular Measurements

et al. 2018

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Tumor microvascularization is a biomarker of response to antiangiogenic treatments and is accurately assessed by ultrasound imaging. Imaging modes used to visualize slow flows include Power Doppler imaging, dynamic contrast-enhanced ultrasonography, and more recently, microvascular Doppler. Flow phantoms are used to evaluate the performance of Doppler imaging techniques, but they do not have a steady flow and sufficiently small channels. We report a novel device for robust and stable microflow measurements and the study of the microvascularization. Based on microfluidics technology, the prototype features wall-less cylindrical channels of diameters ranging from as small as 147 up to 436 µm, cast in a soft silicone polymer and perfused via a microfluidic flow pressure controller. The device was assessed using flow rates from 49 to 146 µL/min, with less than 1% coefficient of variation over three minutes, corresponding to velocities of 6 to 142 mm/s. This enabled us to evaluate and confirm the reliability of the Superb Microvascular Imaging Doppler mode compared with the Power Doppler mode at these flow rates in the presence of vibrations mimicking physiological motion.

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Section: Discussionmentioning

confidence: 99%

A Novel Microflow Phantom Dedicated to Ultrasound Microvascular Measurements

et al. 2018

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“…For example, single-crystal technology (Gururaja et al 1999;Rehrig et al 2003) has led to considerable improvements in bandwidth and sensitivity and resulted in greatly improved contrast modes. The use of the broad bandwidth capacitive micromachined ultrasonic transducers for nonlinear applications like the detection of microbubbles is challenged by their inherent non-linearity on transmit, but their application to contrast imaging is still an active area of research (Lohfink and Eccardt 2005;Balantekin and Degertekin 2008;Fouan and Bouakaz 2016).…”

Section: Transducersmentioning

confidence: 99%

Imaging Methods for Ultrasound Contrast Agents

Averkiou

Bruce

Powers

et al. 2020

Ultrasound in Medicine & Biology

122

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Microbubble contrast agents were introduced more than 25 years ago with the objective of enhancing blood echoes and enabling diagnostic ultrasound to image the microcirculation. Cardiology and oncology waited anxiously for the fulfillment of that objective with one clinical application each: myocardial perfusion, tumor perfusion and angiogenesis imaging. What was necessary though at first was the scientific understanding of microbubble behavior in vivo and the development of imaging technology to deliver the original objective. And indeed, for more than 25 years bubble science and imaging technology have evolved methodically to deliver contrast-enhanced ultrasound. Realization of the basic bubbles properties, non-linear response and ultrasound-induced destruction, has led to a plethora of methods; algorithms and techniques for contrast-enhanced ultrasound (CEUS) and imaging modes such as harmonic imaging, harmonic power Doppler, pulse inversion, amplitude modulation, maximum intensity projection and many others were invented, developed and validated. Today, CEUS is used everywhere in the world with clinical indications both in cardiology and in radiology, and it continues to mature and evolve and has become a basic clinical tool that transforms diagnostic ultrasound into a functional imaging modality. In this review article, we present and explain in detail bubble imaging methods and associated artifacts, perfusion quantification approaches, and implementation considerations and regulatory aspects.

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“…Secondly, CMUT has a large frequency range. In addition, the CMUT can be integrated with the signal conditioning circuit to form a chip [6], which reduces the influence of external interference signals introduced during the module connection and the parasitic capacitance between the signal conditioning circuits and reduces the energy conversion. The volume of the device realizes the miniaturized design of the ultrasound imaging system [7].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Cell Structure for Wideband CMUT: Design Method and Characteristic Analysis

Wang¹,

Huang²,

Yu³

et al. 2021

Micromachines

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Capacitive micromachined ultrasonic transducer (CMUT) is an ultrasonic transducer based on the microelectromechanical system (MEMS). Wideband CMUT has good application prospects in ultrasonic imaging, ultrasonic identification, flow measurement, and nondestructive testing due to its excellent characteristics. This paper studies the method of increasing the bandwidth of the CMUT, proposes the structure of the wideband CMUT with a hybrid cell structure, and analyzes the design principles and characteristics of the wideband CMUT structure. By changing the cell spacing and the number of cells of different sizes composing the CMUT, we analyze the simulation of the effect of the spacing and number on the CMUT bandwidth, thereby optimizing the bandwidth characteristics of the CMUT. Next, the selection principle of the main structural parameters of the wideband CMUT is analyzed. According to the proposed principle, the CMUT in the air and water are designed and simulated. The results prove that both the air and water CMUT meet the design requirements. The design rules obtained in this paper can provide theoretical guidance for the selection of the main structural parameters of the wideband CMUT.

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Investigation of Classical Pulse Sequences for Contrast-Enhanced Ultrasound Imaging With a cMUT Probe

Cited by 21 publications

References 50 publications

A Novel Microflow Phantom Dedicated to Ultrasound Microvascular Measurements

A Novel Microflow Phantom Dedicated to Ultrasound Microvascular Measurements

Imaging Methods for Ultrasound Contrast Agents

Hybrid Cell Structure for Wideband CMUT: Design Method and Characteristic Analysis

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