Investigation of CMV and Rubella Seroprevalence and Age Related Distribution in Pregnant Women

Gülseren, Yasemin Derya; Taşbent, Fatma Esenkaya; Özdemir, Mehmet

doi:10.5222/tmcd.2019.154

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Upon reviewing recent CMV seroprevalence studies from various cities in Turkey, it was found that CMV IgG seropositivity varied from 94% to 100% [ 27 , 28 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…Upon reviewing recent CMV seroprevalence studies from various cities in Turkey, it was found that CMV IgG seropositivity varied from 94% to 100% [27,28,[30][31][32][33][34][35][36][37] (Table 4). The variability in seropositivity has been linked to factors such as living conditions, economic and demographic characteristics, hygiene, and cultural and behavioral factors [32].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Congenital Cytomegalovirus Infection in Pregnant Women Admitted to a University Hospital in Istanbul

Ozdemir,

Sarac Sivrikoz,

Sarsar

et al. 2024

Viruses

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Cytomegalovirus (CMV) can cause serious complications in immunocompromised individuals and fetuses with congenital infections. These can include neurodevelopmental impairments and congenital abnormalities in newborns. This paper emphasizes the importance of concurrently evaluating ultrasonography findings and laboratory parameters in diagnosing congenital CMV infection. To examine the prenatal characteristics of CMV DNA-positive patients, we assessed serum and amniotic fluid from 141 pregnant women aged 19–45 years, each with fetal anomalies. ELISA and PCR tests, conducted in response to these amniocentesis findings, were performed at an average gestational age of 25 weeks. Serological tests revealed that all 141 women were CMV IgG-positive, and 2 (1.41%) had low-avidity CMV IgG, suggesting a recent infection. CMV DNA was detected in 17 (12.05%) amniotic fluid samples using quantitative PCR. Of these, 82% exhibited central nervous system abnormalities. Given that most infections in pregnant women are undetectable and indicators non-specific, diagnosing primary CMV in pregnant women using clinical findings alone is challenging. We contend that serological tests should not be the sole means of diagnosing congenital CMV infection during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Congenital Cytomegalovirus Infection in Pregnant Women Admitted to a University Hospital in Istanbul

Ozdemir,

Sarac Sivrikoz,

Sarsar

et al. 2024

Viruses

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Evaluation of Toxoplasma gondii, CMV, and Rubella Seropositivity and Avidity Tests in the First Trimester of Pregnancy: Why to Test?

UĞUR,

ESENKAYA,

GÜNENC

2023

Journal of Biotechnology and Strategic Health Research

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Objective: The influence of intrauterine and perinatal infections on fetal and neonatal mortality rates and childhood morbidity is substantial. Toxoplasmosis gondii, cytomegalovirus (CMV), and rubella are widely recognized as the major causative agents of in utero infection. The surveillance of preventable and treatable diseases within populations at risk are crucial for public health. The objective of this study is to investigate the seropositivity rates and avidity incidences of T. gondii, CMV, and rubella in pregnant women during the first trimester. Methods: The electrochemiluminescence immunoassay method (Elecsys, Roche, Germany) was employed for the detection of the anti-Toxo IgM, anti-Toxo IgG, anti-CMV IgM, anti-CMV IgG, anti-rubella IgM, and anti-rubella IgG during the time period of January 1, 2021, to June 15, 2023. The anti-Toxo IgG, anti-CMV, and anti-rubella IgG avidity tests were performed with the enzyme-linked fluorescent assay method (VIDAS, bioMérieux, France). Results: The T. gondii IgM incidance was 2.1%; and the T. gondii IgG seroprevalance was 22%. For T. gondii, low avidity was observed in 13.6% (n = 31) of cases, while high avidity index was detected in 75.8% (n = 172) of cases. The anti-CMV IgM incidance was 1.6%; while IgG seroprevalance was 96.9%. The IgG avidity with a high index for CMV was determined as 99.4%. The anti-rubella IgM incidance was 0.8%; while the IgG seroprevalance was found to be 98.7%. The IgG avidity with a high index for Rubella was 99.1%. Conclusion: Seroprevalance of T.gondii, CMV, and rubella may vary according to geographical and socioeconomic conditions. Treatment for T. gondii diagnosed during pregnancy, preventive behavioral measures for CMV and vaccination against rubella prior to pregnancy may help reduce congenital infections. The prioritization of T. gondii, CMV, and rubella screening in high-risk populations, including women of reproductive age and pregnant women, is crucial for public health.

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Bir ilçedeki gebelerde TORCH seroprevalansının araştırılması

Kılıç

Ersak

YALÇINKAYA³

2022

Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi

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Aim:The aim of this study to evaluate the seroprevalence of toxoplasmosis, rubella, CMV, syphilis, HIV and hepatitis B&C infections among pregnant women at the first trimester in a district and to discuss whether it is necessary to screen for these infections during routine pregnancy follow -up. Materials and Method:This study included 259 pregnant women who applied to the single Obstetrics and Gynecology outpatient clinic in a district within one year.Rubella IgM&IgG, toxoplasma IgM&IgG, CMV IgM&IgG, HBsAg, anti-HCV, anti-HIV and syphilis (VDRL-RPR) serologies were examined from the venous blood sample taken in the first trimester of pregnancy.Results: Rubella IgG antibodies detected in 255 (98.5%) patients, CMV IgG antibodies in 254 (98.1%) patients, toxoplasma IgG antibodies in 58 (22.4%) patients. Only one patient was positive for Anti-Toxoplasma IgM and IgG antibodies. None of the patients were positive for Rubella IgM, CMV IgM, anti-HCV and anti-HIV antibodies.HBsAg positivity was detected in 2 (0.8%) patients and VDRL-RPR positivity in other 2 patients. Positive results for Hepatitis B disease was confirmed by HBV DNA test in two patients and syphilis disease was confirmed by TPHA test in one patient. Conclusion:Due to the protective effects of rubella vaccination and acquired immunity in the pre-pregnancy period of CMV infection, screening for these infections during pregnancy may not be appropriate. The high seronegativity rates determined for toxoplasmosis in our region indicate that it will be useful to screen for toxoplasmosis in the first antenatal visit. If possible, in the preconceptional period, vaccination should be recommended after the routine screening for hepatitis B infection done.Considering the cost of the screening for hepatitis C, HIV and syphilis infections and low prevalence in our region, screening of high-risk groups seems more convenient.However, the Ministry of Health recommends that all pregnant women be screened for HIV and syphilis infections in line with the goals set by the United Nations.

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Investigation of CMV and Rubella Seroprevalence and Age Related Distribution in Pregnant Women

Cited by 3 publications

References 24 publications

Evaluation of Congenital Cytomegalovirus Infection in Pregnant Women Admitted to a University Hospital in Istanbul

Evaluation of Congenital Cytomegalovirus Infection in Pregnant Women Admitted to a University Hospital in Istanbul

Evaluation of Toxoplasma gondii, CMV, and Rubella Seropositivity and Avidity Tests in the First Trimester of Pregnancy: Why to Test?

Bir ilçedeki gebelerde TORCH seroprevalansının araştırılması

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