Investigation of coagulation and serum biochemistry profiles in dairy cattle with different degrees of fatty liver

Gerspach, Christian; Ruetten, Maja; Riond, Barbara

doi:10.17236/sat00096

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…A further explanation for the lower glucose concentrations can be attributed to the greater demand for milk lactose synthesis, whose concentration was continuously elevated throughout the experiment in H-Chol. (Gerspach et al, 2016;Rehage et al, 1996;Reid & Collins, 1980), but may not necessarily be pathological. In this respect, Petzold et al (2015) refer to a likely enhanced capability…”

Section: Discussionmentioning

confidence: 99%

Plasma cholesterol levels and short‐term adaptations of metabolism and milk production during feed restriction in early lactating dairy cows on pasture

Gross

Schwinn

Müller

et al. 2021

Animal Physiology Nutrition

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Low plasma total cholesterol (TC) concentrations are characteristic during the negative energy balance in early lactating dairy cows. The objective was to investigate short-term effects of different TC concentrations during an aggravated energy deficiency through a 1-week concentrate withdrawal on adaptations of metabolism and milk production. Multiparous Holstein cows (n = 15) were investigated during 3 week beginning at 24 ± 7 DIM (mean ± SD). Cows were kept on pasture and received additional concentrate in experimental week 1 and 3, while in week 2, concentrate was withdrawn. Blood was sampled once and milk twice daily. Based on their average TC concentration during week 1 (prior to concentrate withdrawal), cows were retrospectively assigned into a high (H-Chol; n = 8, TC ≥ 3.36 mmol/L) and a low TC groups (L-Chol; n = 7, TC < 3.36 mmol/L). Concentrations of phospholipids and lipoproteins were higher in H-Chol compared to L-Chol throughout the study (p < 0.05). During concentrate withdrawal, milk yield, glucose and insulin concentrations decreased similarly in both groups, while milk fat, milk acetone and plasma BHB were higher in H-Chol compared to L-Chol (p < 0.05). Compared to initial values, plasma NEFA, TAG and VLDL increased in both groups within 2 days after concentrate withdrawal (p < 0.05). Concentrations of NEFA during week 2 were greater in L-Chol compared to H-Chol (p < 0.05). Despite reintroduction of concentrate, milk yield in H-Chol remained lower for two more days compared to week 1 (p < .05), whereas milk yield recovered immediately in L-Chol. Activity of aspartate aminotransferase was higher in H-Chol compared to L-Chol in week 2 (p < 0.05). Greater plasma TC concentrations were associated with a reduced increase of NEFA. Further research is warranted if TC concentrations are related to adipose tissue mobilization and fatty acid turnover.

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Section: Discussionmentioning

confidence: 99%

Plasma cholesterol levels and short‐term adaptations of metabolism and milk production during feed restriction in early lactating dairy cows on pasture

Gross

Schwinn

Müller

et al. 2021

Animal Physiology Nutrition

View full text Add to dashboard Cite

show abstract

“…For example, serum proteins, such as fibroblast growth factor-21, hemoglobin, and angiopoietin-like protein 4 can be used as fatty liver biomarkers in lactating dairy cows ( Shen et al., 2018 ; Wang et al., 2018 ). Gerspach et al. (2016) found that AST, rather than NEFA, TC, or TG, is a biochemical parameter that distinguishes cows with fatty liver.…”

Section: Discussionmentioning

confidence: 93%

The crucial role of lysine in the hepatic metabolism of growing Holstein dairy heifers as revealed by LC-MS-based untargeted metabolomics

Kong

Diao

et al. 2021

Animal Nutrition

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The objective of this experiment was to evaluate the effect of supplementing rumen-protected Lys based on a Lys-deficient diet on liver metabolism in growing Holstein heifers. The experiment was conducted for 3 months with 36 Holstein heifers (initial body weight: 200 ± 9.0 kg; 7-month-old). Heifers were randomly assigned to 2 diets based on corn, soybean meal, alfalfa hay, and wheat bran: control, Lys-deficient diet (LD; 0.66% Lys in diet), and Lys-adequate diet (LA; 1.00% Lys in diet). The results showed no difference in growth performance between the 2 groups ( P > 0.05). However, there was a clear trend of increasing feed conversion rate with Lys supplementation (0.05 < P < 0.01). The serum urea nitrogen concentration was significantly decreased, and the aspartate aminotransferase-to-alanine aminotransferase ratio was significantly decreased by Lys supplementation ( P < 0.05). Moreover, growing heifers fed a Lys-adequate diet had lower levels of urine nitrogen excretion and higher levels of the biological value of nitrogen ( P < 0.05). Metabolomic analysis revealed that 5 types of phosphatidylcholine and 3 types of ceramide were significantly increased and enriched in sphingolipid metabolism and glycerophospholipid metabolism ( P < 0.05). His, Leu, and Asp levels were significantly decreased in the liver following Lys supplementation ( P < 0.05). In conclusion, Lys supplementation may promote the synthesis of body tissue proteins, as evidenced by significantly decreased amino acids in the liver and urine N excretion, it also improves hepatic lipid metabolism by providing lipoprotein precursors.

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Hemato-biochemical and ultrasonographic evaluation of hepatic lipidosis in dairy buffaloes

Patel

Suthar²,

Prajapati³

et al. 2022

Trop Anim Health Prod

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Investigation of coagulation and serum biochemistry profiles in dairy cattle with different degrees of fatty liver

Cited by 3 publications

References 15 publications

Plasma cholesterol levels and short‐term adaptations of metabolism and milk production during feed restriction in early lactating dairy cows on pasture

Plasma cholesterol levels and short‐term adaptations of metabolism and milk production during feed restriction in early lactating dairy cows on pasture

The crucial role of lysine in the hepatic metabolism of growing Holstein dairy heifers as revealed by LC-MS-based untargeted metabolomics

Hemato-biochemical and ultrasonographic evaluation of hepatic lipidosis in dairy buffaloes

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