Investigation of cobalt(iii)–phenylalanine complexes for hypoxia-activated drug delivery

Abstract

Four cobalt(III)-phenylalanine complexes, [Co(Phe)(py2en)](ClO4)2·H2O (1), [Co(Phe)(TPA)](ClO4)2·H2O (2), [Co(Phe)(py2enMe2)](ClO4)2·H2O (3) and [Co(bipy)2(Phe)](ClO4)2·H2O (4), were investigated as prototype models for hypoxia-activated delivery of melphalan - a phenylalanine derivative anticancer drug of the...

Recent Development of Transition Metal Complexes as Chemotherapeutic Hypoxia Activated Prodrug (HAP)

“…The same group has reported another paper where Co(III) complexes under hypoxic condition have been tested for delivery of melphalan – which is a derivative of phenylalanine and nitrogen mustard class of anticancer drug [109] . They have synthesised and characterised four cobalt(III)‐phenylalanine complexes, [Co(Phe)(py 2 en)](ClO 4 ) 2 ⋅ H 2 O ( 34 ), [Co(Phe)(TPA)](ClO 4 ) 2 ⋅ H 2 O ( 35 ), [Co(Phe)(py 2 enMe 2 )](ClO4) 2 ⋅ H 2 O ( 36 ) and [Co(bipy) 2 (Phe)](ClO 4 ) 2 ⋅ H 2 O ( 37 ) (Figure 9).…”

Development of a cobalt(iii)-based ponatinib prodrug system

“…34,42,43 Interestingly, for most cobalt(III) prodrugs reported in literature irreversible redox processes in aqueous solutions could be observed, which contradicts this hypothesis. [44][45][46][47] Notably, pulse radiolysis studies of cobalt(III) nitrogen mustard complexes indeed suggested that the re-oxidation rate under normoxia is too slow and the cobalt(III) complexes rather compete with molecular oxygen for one-electron reductants. 48 Nevertheless, different cobalt(III) complexes with irreversible electrochemical behavior exhibited strong hypoxiadependent activity against cancer cells in vitro and in vivo, proving the potential of such complexes.…”

Cobalt(ii) terpyridine complexes: synthesis, characterization, antiproliferative activity and molecular docking with proteins and DNA

“…31 (iii) Compared to platinum and ruthenium in the same group, it has the advantage of being inexpensive and easily accessible. 32 Recently, biological functional studies on several compounds containing Co 2+ have already been carried out. A series of Co( ii ) complexes of terpyridine, such as [Co(L) 2 ](ClO 4 ) 2 , have been synthesized by Sovan Roy et al , 33 and their photocytotoxicity and cellular uptake properties have been studied.…”