Investigation of cognitive circuits using steady-state cerebral blood volume and diffusion tensor imaging in patients with mild cognitive impairment following electrical injury

Park, Chang-Hyun; Seo, Cheong Hoon; Jung, Myung Hun; Joo, So Young; Jang, Soyeon; Lee, Ho‐Young; Ohn, Suk Hoon

doi:10.1007/s00234-017-1876-1

Cited by 5 publications

(6 citation statements)

References 33 publications

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“…Moreover, the pattern of CBV change was somewhat similar to each other in the pain discriminative network and the motor network. The cerebral pain network of EB group in this study is less likely to be directly affected by the electrical current through the peripheral nerve and spinal cord, which is similar to the results of other studies [22,23]. If the electrical current had an effect on the brain, watershed zones vulnerable to insufficient blood flow must have been damaged first.…”

Section: Discussionsupporting

confidence: 86%

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Plastic Changes in Pain and Motor Network Induced by Chronic Burn Pain

Joo

Park

Cho

et al. 2021

JCM

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Musculoskeletal diseases with chronic pain are difficult to control because of their association with both central as well as the peripheral nervous system. In burn patients, chronic pain is one of the major complications that cause persistent discomfort. The peripheral mechanisms of chronic pain by burn have been greatly revealed through studies, but the central mechanisms have not been identified. Our study aimed to characterize the cerebral plastic changes secondary to electrical burn (EB) and non-electrical burn (NEB) by measuring cerebral blood volume (CBV). Sixty patients, twenty with electrical burn (EB) and forty with non-electrical burn (NEB), having chronic pain after burn, along with twenty healthy controls, participated in the study. Voxel-wise comparisons of relative CBV maps were made among EB, NEB, and control groups over the entire brain volume. The CBV was measured as an increase and decrease in the pain and motor network including postcentral gyrus, frontal lobe, temporal lobe, and insula in the hemisphere associated with burned limbs in the whole burn group. In the EB group, CBV was decreased in the frontal and temporal lobes in the hemisphere associated with the burned side. In the NEB group, the CBV was measured as an increase or decrease in the pain and motor network in the postcentral gyrus, precentral gyrus, and frontal lobe of the hemisphere associated with the burn-affected side. Among EB and NEB groups, the CBV changes were not different. Our findings provide evidence of plastic changes in pain and motor network in patients with chronic pain by burn.

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Section: Discussionsupporting

confidence: 86%

“…Processing of CBV mapping data was performed using SPM12 software (The Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, London, UK), as in previous studies [22,23]. Two structural images from each participant were processed following routines specified in SPM12 software.…”

Section: Mri Acquisition and Cbv Mappingmentioning

confidence: 99%

Plastic Changes in Pain and Motor Network Induced by Chronic Burn Pain

Joo

Park

Cho

et al. 2021

JCM

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“…In MCI (mild cognitive impairment, Braak stages III and IV) no decrease in the mamillary body volume was found, whereas significant reduction in the volume of the mamillary body and fornix was apparent at the conversion of the MCI to AD (25). Functional magnetic resonance imaging study in MCI patients also showed hypermetabolism in the cerebellolimbic system involving the MMN using cerebral blood volume measures which the authors related to a cognitive reserve protecting against dementia (26). This means that whereas the volume of the MMN becomes smaller due to the death of some MMN cells, the remaining ones compensate by an enlargement.…”

Section: Discussionmentioning

confidence: 97%

Increased Neuronal Nuclear and Perikaryal Size in the Medial Mamillary Nucleus of Vascular Dementia and Alzheimer’s Disease Patients: Relation to Nuclear Estrogen Receptor α

Ishunina¹,

Bogolepova²,

Swaab³

2019

Dement Geriatr Cogn Disord

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The medial mamillary nucleus (MMN) is an important hub in memory circuits. In the present study, we aimed at determining MMN neuronal nuclear and pericaryal sizes that are informative about the neuronal metabolic activity in Alzheimer's disease (AD) in vascular dementia (VD) patients. Both parameters were significantly larger in VD than in control patients (p<0.01) and were not different from those in AD subjects. Neuronal nuclei (p<0.05), but not pericarya were larger in AD than in control patients. Neuronal nuclei and pericarya were larger if nuclear ERα staining was present. The intensity of ERα in the neuronal nuclei was significantly correlated with both nuclear and pericaryal sizes (p<0.007). The only exception was the strongest ERα staining providing a totally black cover over the nucleus that was increased in AD patients. In this case the nuclei and pericarya were smaller than in moderate intensity staining that allowed visualization of the nucleolus and large chromatin clumps. Our data show for the first time prominent activation of MMN neurons in VD and to a lesser degree in AD that may be mediated by nuclear ERα. Our findings are in agreement with the idea that neuronal activation may protect against AD neuropathological alterations.

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“…A single-shot diffusion-weighted echo planar imaging sequence was taken in the same manner as Joo et al to assess the CBV changes caused by the burn-related chronic pain [ 18 ]. Processing of the CBV mapping data was performed using SPM12 software ( , accessed on 8 May 2022), as previously described [ 21 , 30 ]. The pre- and post-contrast images were spatially transformed to the same standard space, and then a map of the contrast-induced signal difference ratios was acquired using the equation: (post-contrast signal − pre-contrast signal)/(maximum signal difference in the superior sagittal sinus) × 100.…”

Section: Methodsmentioning

confidence: 99%

“…The cerebral blood volume (CBV) is a hemodynamic variable that represents the fraction of the cerebral tissue volume occupied by blood at a given time point, which is highly correlated with oxygen metabolism. Although lower in temporal resolution than deoxyhemoglobin fMRI, T1-weighted post gadolinium measurement of CBV offer resolution superior to other techniques and is the only fMRI measure that is currently amenable to submillimeter resolution functional maps [ 21 ]. This randomized controlled trial was to investigate the pain-suppressing effect of ST and the mechanism of its effect on the cerebral pain network in patients with chronic neuropathic pain caused by burns.…”

Section: Introductionmentioning

confidence: 99%

Scrambler Therapy for Chronic Pain after Burns and Its Effect on the Cerebral Pain Network: A Prospective, Double-Blinded, Randomized Controlled Trial

Lee

Park

Cho

et al. 2022

JCM

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Chronic pain is common after burn injuries, and post-burn neuropathic pain is the most important complication that is difficult to treat. Scrambler therapy (ST) is a non-invasive modality that uses patient-specific electrocutaneous nerve stimulation and is an effective treatment for many chronic pain disorders. This study used magnetic resonance imaging (MRI) to evaluate the pain network-related mechanisms that underlie the clinical effect of ST in patients with chronic burn-related pain. This prospective, double-blinded, randomized controlled trial (ClinicalTrials.gov: NCT03865693) enrolled 43 patients who were experiencing chronic neuropathic pain after unilateral burn injuries. The patients had moderate or greater chronic pain (a visual analogue scale (VAS) score of ≥5), despite treatment using gabapentin and other physical modalities, and were randomized 1:1 to receive real or sham ST sessions. The ST was performed using the MC5-A Calmare device for ten 45 min sessions (Monday to Friday for 2 weeks). Baseline and post-treatment parameters were evaluated subjectively using the VAS score for pain and the Hamilton Depression Rating Scale; MRI was performed to identify objective central nervous system changes by measuring the cerebral blood volume (CBV). After 10 ST sessions (two weeks), the treatment group exhibited a significant reduction in pain relative to the sham group. Furthermore, relative to the pre-ST findings, the post-ST MRI evaluations revealed significantly decreased CBV in the orbito-frontal gyrus, middle frontal gyrus, superior frontal gyrus, and gyrus rectus. In addition, the CBV was increased in the precentral gyrus and postcentral gyrus of the hemisphere associated with the burned limb in the ST group, as compared with the CBV of the sham group. Thus, a clinical effect from ST on burn pain was observed after 2 weeks, and a potential mechanism for the treatment effect was identified. These findings suggest that ST may be an alternative strategy for managing chronic pain in burn patients.

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Investigation of cognitive circuits using steady-state cerebral blood volume and diffusion tensor imaging in patients with mild cognitive impairment following electrical injury

Cited by 5 publications

References 33 publications

Plastic Changes in Pain and Motor Network Induced by Chronic Burn Pain

Plastic Changes in Pain and Motor Network Induced by Chronic Burn Pain

Increased Neuronal Nuclear and Perikaryal Size in the Medial Mamillary Nucleus of Vascular Dementia and Alzheimer’s Disease Patients: Relation to Nuclear Estrogen Receptor α

Scrambler Therapy for Chronic Pain after Burns and Its Effect on the Cerebral Pain Network: A Prospective, Double-Blinded, Randomized Controlled Trial

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