Investigation of copper-cysteamine nanoparticles as a new photosensitizer for anti-hepatocellular carcinoma

Huang, Xuejing; Wan, Fengjie; Ma, Li; Phan, Jonathan; Lim, Rebecca Xueyi; Li, Cuiping; Chen, Jiagui; Deng, Jing-Huan; Li, Yasi; Chen, Wei; He, Min

doi:10.1080/15384047.2018.1564568

Cited by 36 publications

(20 citation statements)

References 59 publications

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“…In addition, these rare earth doped nanoparticles also have strong scintillation luminescence that can be used for X-ray induced photodynamic therapy, which is a very hot area, as this new therapy can be used for deep as well as skin cancer treatment [ 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 ].…”

Section: Biological Applications Of Ucnpsmentioning

confidence: 99%

Recent Advances of Upconversion Nanomaterials in the Biological Field

et al. 2021

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Rare Earth Upconversion nanoparticles (UCNPs) are a type of material that emits high-energy photons by absorbing two or more low-energy photons caused by the anti-stokes process. It can emit ultraviolet (UV) visible light or near-infrared (NIR) luminescence upon NIR light excitation. Due to its excellent physical and chemical properties, including exceptional optical stability, narrow emission band, enormous Anti-Stokes spectral shift, high light penetration in biological tissues, long luminescent lifetime, and a high signal-to-noise ratio, it shows a prodigious application potential for bio-imaging and photodynamic therapy. This paper will briefly introduce the physical mechanism of upconversion luminescence (UCL) and focus on their research progress and achievements in bio-imaging, bio-detection, and photodynamic therapy.

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Section: Biological Applications Of Ucnpsmentioning

confidence: 99%

Recent Advances of Upconversion Nanomaterials in the Biological Field

et al. 2021

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“…Huang et al found that in photodynamic therapy, the soluble nanodrugs were able to enter exosomes secreted by tumor cells, and supposed that exosomes could be used to deliver drugs to target pancreatic cells. 51 Of particular concern, additional characters of exosomes in delivering functional cargos to diseased cells also favor their use as drug deliveries. The lipid and protein composition and other natural constituents of exosomes play a role in enhanced bioavailability and in minimizing adverse reactions, suggesting that biocompatibility is guaranteed and systemic toxicity does not need to be taken into consideration when compared with artificial chemical delivery vehicles.…”

Section: Exosomes Based Npsmentioning

confidence: 99%

Section: Biofilm Nanoparticlesmentioning

confidence: 99%

<p>A Review of Biomimetic Nanoparticle Drug Delivery Systems Based on Cell Membranes</p>

Zhang¹,

Du²,

Wang³

et al. 2020

DDDT

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Cancers have always been an intractable problem because of recurrence and drug resistance. In the past few decades, nanoparticles have been explored intensely to diagnose, prevent and treat malignancy due to their good penetrability and better targeting. However, most nanocarriers have poor biodegradation and can be discharged out of the body quickly or cleared by immune cells while failing to obtain effective drug concentration at the specific sites. The emergence of biological membrane encapsulation technology relieves the fast clearance of antitumor drugs and reduces toxicity in vivo. This review will discuss the advantages and disadvantages of several blood cell membrane-coated nanoparticles and further introduce exosome-carried drugs to evidence the promising prospect of biomimetic nanoparticle drug delivery systems.

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“…Notably, Cu-Cy NPs have a striking characteristic compared with other nanoparticle radiosensitizers, because it can act as a photosensitizer to produce ROS directly induced by X-ray [ [11] , [12] , [13] , [14] , [15] ] instead of transferring the absorbed energy from X-ray to other NPs [ 8 , 9 , 16 ]. Previous studies also demonstrate that Cu-Cy NPs have several important applications and tremendous potential for cancer therapy in vitro or with subcutaneous tumor models in vivo under laboratory environment when activated by UV [ 10 , 17 ], X-ray [ [11] , [12] , [13] , [14] , [15] ], microwaves [ 6 , 18 ], or ultrasound [ 19 ]. Here, for the first time, we performed the study of Cu-Cy nanoparticles using deeply-located models to mimic the clinical conditions by a clinical linear accelerator with a lower RT dose in order to comprehensively understand the real-world biomedical applications of Cu-Cy NPs in different biological levels.…”

Section: Introductionmentioning

confidence: 99%

Study of copper-cysteamine based X-ray induced photodynamic therapy and its effects on cancer cell proliferation and migration in a clinical mimic setting

Chen

Liu

et al. 2022

Bioactive Materials

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Copper-cysteamine as a new generation of sensitizers can be activated by light, X-rays, microwaves, or ultrasound to produce reactive oxygen species. X-ray induced photodynamic therapy (X-PDT) has been studied extensively; however, most of the studies reported so far were conducted in the laboratory, which is not conducive to the clinical translation conditions. In this contribution, for the first time, we investigated the treatment efficiency of copper-cysteamine (Cu-Cy) based X-PDT by mimicking the clinical conditions with a clinical linear accelerator and building deep-seated tumor models to study not only the effectiveness but also its effects on the cell migration and proliferation in the level of the cell, tissue, and animal. The results showed that, without X-ray irradiation, Cu-Cy nanoparticles (NPs) had a low toxicity in HepG2, SK-HEP-1, Li-7, and 4T1 cells at a concentration below 100 mg/L. Interestingly, for the first time, it was observed that Cu-Cy mediated X-PDT can inhibit the proliferation and migration of these cell lines in a dose-dependent manner. Antigen markers of migration and cell proliferation, proliferating cell nuclear antigen (PCNA) and E-cadherin, from tumor tissue in the X-PDT group were remarkably different from that of the control group. Furthermore, the MRI assessment showed that the Cu-Cy based X-PDT inhibited the growth of deeply located tumors in mice and rabbits ( p < 0.05) without any obvious toxicities in vivo . Overall, these new findings demonstrate that Cu-Cy NPs have a safe and promising clinical application prospect in X-PDT to improve the efficiency of radiotherapy (RT) for deep-seated tumors and effectively inhibit tumor cell proliferation and migration.

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Investigation of copper-cysteamine nanoparticles as a new photosensitizer for anti-hepatocellular carcinoma

Cited by 36 publications

References 59 publications

Recent Advances of Upconversion Nanomaterials in the Biological Field

Recent Advances of Upconversion Nanomaterials in the Biological Field

<p>A Review of Biomimetic Nanoparticle Drug Delivery Systems Based on Cell Membranes</p>

Study of copper-cysteamine based X-ray induced photodynamic therapy and its effects on cancer cell proliferation and migration in a clinical mimic setting

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