Investigation of copper-PTSM as a PET tracer for tumor blood flow

Mathias, Carla J.; Welch, Michael J.; Perry, David J.; McGuire, Andrea H.; Zhu, Xiaorong Ronald; Connett, Judith M.; Green, M. A.

doi:10.1016/0883-2897(91)90022-d

Cited by 27 publications

(18 citation statements)

References 5 publications

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“…In addition, blood flow and hypoxia are complex inter-related factors, and imaging both together can provide complementary information to help guide treatment selection, planning, and early response monitoring (Bruehlmeier et al, 2004, Lehtio et al, 2004, Lehtio et al, 2001, Rajendran and Krohn, 2005. PTSM (Flower et al, 2001, Mathias et al, 1994, Mathias et al, 1991 and ATSM (Dehdashti et al, 2003, Fujibayashi et al, 1997, Lewis et al, 1999, Lewis et al, 2001, Takahashi et al, 2000 are chemical analogues. While PTSM distributes in proportion to blood flow and is rapidly reduced and trapped in tissues, ATSM has a lower redox potential and is selectively retained in hypoxic tissues.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of rapid dual-tracer⁶²Cu-PTSM +⁶²Cu-ATSM PET in dogs with spontaneously occurring tumors

et al. 2007

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We are developing methods for imaging multiple PET tracers in a single scan with staggered injections, where imaging measures for each tracer are separated and recovered using differences in tracer kinetics and radioactive decay. In this work, signal-separation performance for rapid dual-tracer 62 Cu-PTSM (blood flow) + 62 Cu-ATSM (hypoxia) tumor imaging was evaluated in a large animal model. Four dogs with pre-existing tumors received a series of dynamic PET scans with 62 Cu-PTSM and 62 Cu-ATSM, permitting evaluation of a rapid dual-tracer protocol designed by previous simulation work. Several imaging measures were computed from the dual-tracer data and compared with those from separate, single-tracer imaging. Static imaging measures (e.g. SUV) for each tracer were accurately recovered from dual-tracer data. The wash-in (k 1 ) and washout (k 2 ) rate parameters for both tracers were likewise well recovered (r = 0.87 -0.99), but k 3 was not accurately recovered for PTSM (r = 0.19) and moderately well recovered for ATSM (r = 0.70). Some degree of bias was noted, however, which may potentially be overcome through further refinement of the signal-separation algorithms. This work demonstrates that complementary information regarding tumor blood flow and hypoxia can be acquired by a single dual-tracer PET scan, and also that the signal-separation procedure works effectively for real physiologic data with realistic levels of kinetic model-mismatch. Rapid multi-tracer PET has the potential to improve tumor assessment for image-guide therapy and monitoring, and further investigation with these and other tracers is warranted.

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Section: Introductionmentioning

confidence: 99%

Evaluation of rapid dual-tracer⁶²Cu-PTSM +⁶²Cu-ATSM PET in dogs with spontaneously occurring tumors

et al. 2007

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“…Interestingly, [Cu(II)-PTSM] is also reported to be retained in tumours. Once again this retention is thought to be the due to the reduction of the Cu(II) ion in the complex to Cu(I) in the hypoxic tumour cells, followed by its liberation from the complex and its intracellular entrapment [39][40][41]. This has led to a new area of redox active 64 Cu complexes for use in imaging hypoxia [42][43][44][45].…”

Section: Copper Radioisotopesmentioning

confidence: 95%

Molecular imaging with copper-64

Smith

2004

Journal of Inorganic Biochemistry

210

161

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“…The metal containing thiosemicarbazone compounds have a wide range of biological activities as antiviral, antibacterial and antitumor depending on the parent aldehyde, ketone and of course metal ion [2][3][4][5][6][7][8]. Among the metal complexes of thiosemicarbazones, the copper(II) [9][10][11][12] and palladium(II) [13][14][15][16] chelates have been studied especially regarding their antitumor potentials. Besides some of palladium(II) complexes of thiosemicarbazones are also known as antiviral agents [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Copper(II) and palladium(II) complexes of 2-amino-5-chlorobenzophenone and 2-(2-hydroxybenzylidene)amino-5-chlorobenzophenone-S-methyl-thiosemicarbazones

Kurt

Ülküseven

Güner

et al. 2007

Transition Met Chem

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The S-methyl thiosemicarbazone derivatives of 2-amino-5-chlorobenzophenone and 2-(2-hydroxybenzylidene)amino-5-chlorobenzophenone (L I and L II ) and their copper(II) and palladium(II) chelates were synthesized. The solid compounds, [Cu(L I )Cl]Cl AE 2H 2 O, [Cu(L II )Cl]Cl AE H 2 O, [Pd(L I )Cl]Cl, and [Pd(L II )Cl 2 ], were characterized by elemental analysis, thermogravimetric measurements, electronic, i.r., 1 H-n.m.r. and e.p.r. spectroscopy. The ligand behavior of the L I and L II explained by means of spectroscopic data. The experimental X-band e.p.r. spectra recorded from two different copper(II) ion coordinated powder complexes have characteristic line shapes that exhibit the axial symmetry around the paramagnetic ions. The theoretically well fitted spectra prove this case too. The absence of hyperfine signals has been attributed to the strong covalency effects of copper electrons with neighbouring N atoms. Orbital energy levels for magnetic electrons were determined from Spin Hamiltonian parameters. The anisotropic Lande splitting factors were specified in an order of g jj >g ? >2 and this case indicates that the unpaired electrons are located mainly in the d x 2 Ày 2 orbital.

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Investigation of copper-PTSM as a PET tracer for tumor blood flow

Cited by 27 publications

References 5 publications

Evaluation of rapid dual-tracer⁶²Cu-PTSM +⁶²Cu-ATSM PET in dogs with spontaneously occurring tumors

Evaluation of rapid dual-tracer⁶²Cu-PTSM +⁶²Cu-ATSM PET in dogs with spontaneously occurring tumors

Molecular imaging with copper-64

Copper(II) and palladium(II) complexes of 2-amino-5-chlorobenzophenone and 2-(2-hydroxybenzylidene)amino-5-chlorobenzophenone-S-methyl-thiosemicarbazones

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Investigation of copper-PTSM as a PET tracer for tumor blood flow

Cited by 27 publications

References 5 publications

Evaluation of rapid dual-tracer62Cu-PTSM +62Cu-ATSM PET in dogs with spontaneously occurring tumors

Evaluation of rapid dual-tracer62Cu-PTSM +62Cu-ATSM PET in dogs with spontaneously occurring tumors

Molecular imaging with copper-64

Copper(II) and palladium(II) complexes of 2-amino-5-chlorobenzophenone and 2-(2-hydroxybenzylidene)amino-5-chlorobenzophenone-S-methyl-thiosemicarbazones

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Evaluation of rapid dual-tracer⁶²Cu-PTSM +⁶²Cu-ATSM PET in dogs with spontaneously occurring tumors

Evaluation of rapid dual-tracer⁶²Cu-PTSM +⁶²Cu-ATSM PET in dogs with spontaneously occurring tumors