Advanced power plant alloys must endure high temperatures and pressures for durations at which creep data are often not available, necessitating the extrapolation of creep life. A recently developed creep life extrapolation method is the Wilshire equations, with which multiple approaches can be used to increase the goodness of fit of available experimental data and improve the confidence level of calculating long-term creep strength at times well beyond the available experimental data. In this article, the Wilshire equation is used to extrapolate the creep life of Inconel 617 and Nimonic 105 to 100,000 h. The use of (a) different methods to determine creep activation energy, (b) region splitting, (c) heat- and processing-specific tensile strength data, and (d) short-duration test data were investigated to determine their effects on correlation and extrapolation. For Inconel 617, using the activation energy of lattice self-diffusion as QC* resulted in a poor fit with the experimental data. Additionally, the error of calculated rupture times worsened when splitting regions. For Nimonic 105, the error was reduced when heat- and processing-specific tensile strengths were used. Extrapolating Inconel 617 creep strength to 100,000 h life gave conservative results when compared to values calculated by the European Creep Collaborative Committee.