Investigation of Curcumin Water Solubility Through Emulsifying with Biocompatible Polyethylene Glycol–Based Polymers

Yildiz, Gulcemal; Aydoğmuş, Zeynep; Şenkal, Bahire Filiz; Turan, Gulcin Torunoglu

doi:10.1007/s12161-019-01555-y

Cited by 7 publications

(3 citation statements)

References 33 publications

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“…Polyethylene glycol (PEG), often utilized as an adhesive, is non-toxic, highly water soluble, and is approved for use both as a food and in a variety of clinical applications by the U.S. Food and Drug Administration [ 38 , 39 , 40 ]. When combined with organic compounds, PEG can enhance the biocompatibility and increase the solubility of poorly water-soluble compounds [ 41 , 42 , 43 ]. It can inhibit the adsorption of transaminase proteins, inhibiting their clearance from blood circulation when modified with PEG, prolonging their half-life in blood, and affecting the transport of drug delivery systems [ 44 , 45 , 46 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity

Ren

Yang

et al. 2021

Pharmaceuticals

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Functionalized gold nanoparticles (AuNPs) have been successfully used in many fields as a result of having low cytotoxicity, good biocompatibility, excellent optical properties, and their ability to target cancer cells. Here, we synthesized AuNP carriers that were modified by hyaluronic acid (HA), polyethylene glycol (PEG), and adipic dihydrazide (ADH). The antitumor drug doxorubicin (Dox) was loaded into AuNP carriers and attached chemically. The Au nanocomposite AuNPs@MPA-PEG-HA-ADH-Dox was able to disperse uniformly in aqueous solution, with a diameter of 15 nm. The results of a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay indicated that AuNP carriers displayed very little toxicity toward cells in high doses, although the antitumor properties of Au nanocomposites were significantly enhanced. Cellular uptake experiments demonstrated that AuNPs modified with hyaluronic acid were more readily ingested by HepG2 and HCT-116 cells, as they have a large number of CD44 receptors. A series of experiments measuring apoptosis such as Rh123 and annexin V-FITC staining, and analysis of mitochondrial membrane potential (MMP) analysis, indicated that apoptosis played a role in the inhibition of cell proliferation by AuNPs@MPA-PEG-HA-ADH-Dox. Excessive production of reactive oxygen species (ROS) was the principal mechanism by which the Au nanocomposites inhibited cell proliferation, leading to apoptosis. Thus, the Au nanocomposites, which allowed cell imaging in real-time and induced apoptosis in specific cell types, represent theragnostic agents with potential for future clinical applications in bowel cancer.

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Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity

Ren

Yang

et al. 2021

Pharmaceuticals

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“…Another example is presented in the research of Khalil et al (2013) [ 98 ], wherein they discovered that in a polylactic-co-glycolic acid and PLGA-polyethylene glycol mixture, nanoparticles containing CCM increased the CCM bioavailability by approximately 15 and 55-times when compared to a water suspension of CCM in rats. Yildiz et al (2019), by employing polyethylene glycol mono-oleate-460 for the oily phase, increased CCM solubility by approximately 710 times compared to raw CCM, and CCM also remained chemically stable in emulsion [ 99 ].…”

Section: Curcumin Bioavailability Improvingmentioning

confidence: 99%

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

et al. 2022

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Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types. Curcumin has a high capacity to form molecular complexes with proteins (such as whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, and natural compounds (e.g., resveratrol, piperine, quercetin). These complexes increase the bioactivity and bioavailability of curcumin. The current review provides these derivatization strategies for curcumin in terms of biological and physico-chemical aspects with a strong focus on different type of proteins, characterization methods, and thermodynamic features of protein–curcumin complexes, and with the aim of evaluating the best performances. The current literature review offers, taking into consideration various biological effects of the CCM, a whole approach for CCM-biomolecules interactions such as CCM-proteins, CCM-nanomaterials, and CCM-natural compounds regarding molecular strategies to improve the bioactivity as well as the bioavailability of curcumin in biological systems.

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“…Frequently employed drugs for the treatment of inflammation include non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen [9], ketoprofen, (S)-naproxen [10], nimesulide [11], meloxicam and celecoxib [12], some plant-derived polyphenols [13], such as quercetin [14], curcumin [15] and chrysophanol [16], and some polyphenol-derived alkaloids, such as capsaicin [17] and piperine [18]. More than 50% of the synthetic and herbal agents/compounds derived with the aim of treating both acute and chronic inflammation possess poor aqueous solubility, which restricts their applicative use.…”

Section: Introductionmentioning

confidence: 99%

An Overview of Nanoemulgels for Bioavailability Enhancement in Inflammatory Conditions via Topical Delivery

et al. 2023

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The anti-inflammatory drugs that are generally available possess the disadvantage of hydrophobicity, which leads to poor permeability and erratic bioavailability. Nanoemulgels (NEGs) are novel drug delivery systems that aim to improve the solubility and permeability of drugs across the biological membrane. The nano-sized droplets in the nanoemulsion enhance the permeation of the formulation, along with surfactants and co-surfactants that act as permeation enhancers and can further improve permeability. The hydrogel component of NEG helps to increase the viscosity and spreadability of the formulation, making it ideal for topical application. Moreover, oils that have anti-inflammatory properties, such as eucalyptus oil, emu oil and clove oil, are used as oil phases in the preparation of the nanoemulsion, which shows a synergistic effect with active moiety and enhances its overall therapeutic profile. This leads to the creation of hydrophobic drugs that possess enhanced pharmacokinetic and pharmacodynamic properties, and simultaneously avoid systemic side effects in individuals with external inflammatory disorders. The nanoemulsion’s effective spreadability, ease of application, non-invasive administration, and subsequent ability to achieve patient compliance make it more suitable for topical application in the combat of many inflammatory disorders, such as dermatitis, psoriasis, rheumatoid arthritis, osteoarthritis and so on. Although the large-scale practical application of NEG is limited due to problems regarding its scalability and thermodynamic instability, which arise from the use of high-energy approaches during the production of the nanoemulsion, these can be resolved by the advancement of an alternative nanoemulsification technique. Considering the potential advantages and long-term benefits of NEGs, the authors of this paper have compiled a review that elaborates the potential significance of utilizing nanoemulgels in a topical delivery system for anti-inflammatory drugs.

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Investigation of Curcumin Water Solubility Through Emulsifying with Biocompatible Polyethylene Glycol–Based Polymers

Cited by 7 publications

References 33 publications

Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity

Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

An Overview of Nanoemulgels for Bioavailability Enhancement in Inflammatory Conditions via Topical Delivery

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