Investigation of deep eutectic solvents as additives to <i>β</i>‐CD for enantiomeric separations of Zopiclone, Salbutamol, and Amlodipine by CE

Mu, Yi; Wu, Xi; Huang, Yanping; Liu, Zhao‐Sheng

doi:10.1002/elps.201900067

Cited by 36 publications

(11 citation statements)

References 14 publications

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“…Cyclodextrins are cyclic sugar molecules with a cavity that enables enantioselective separations of chiral drugs. β-Cyclodextrin − and β-cyclodextrin derivatives ,,− are the most common additives used for chiral separations, although α-cyclodextrins and γ-cyclodextrin derivatives , have also been reported. Cyclodextrins modified with different functional groups were used to resolve different drug enantiomers including methylated β-cyclodextrin for psychoactive drugs in under 4 min .…”

Section: Pharmaceuticalsmentioning

confidence: 99%

“…This included combining β-cyclodextrin with acidic amino acids to improve the resolution of four basic drug molecules . Enantioseparations were found to have 3- to 4-fold improvement in resolution with the use of deep eutectic solvents in combination with the cyclodextrins . In one report, the separation of multiple sets of chiral molecules was tailored to each enantiomeric pair by bracketing injected zones of enantiomers with different combinations of α-cyclodextrin, β-cyclodextrin, and maltodextrin .…”

Section: Pharmaceuticalsmentioning

confidence: 99%

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Challenging Bioanalyses with Capillary Electrophoresis

et al. 2019

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This report covers advances in capillary electrophoresis (CE) from January 2018 through September 2019. A summary of the literature during this time period is insightful. A search performed using the SciFinder Scholar® database for journal reports (limited to English) using the term capillary electrophoresis returned approximately 1,800 publications. Further analysis of this list, depicted in Figure 1, provided a snapshot of activity in biomolecular research. Classes of biomolecules most frequently associated with CE publications were proteins, drugs, DNA and metabolites. Another measure of the impact of CE is the translation of this technology into society. A search of patent activity illustrating this process of CE technology transfer returned 346 patents published in all languages, with a substantial contribution reported only in Chinese (198 patents) or English (98 patents). The versatility of CE for biological systems is exemplified by the rise of the technique in several areas. Metabolomics research involving measurements of large sets of molecules with subtle structural differences benefits from rapid separations achieved with high peak capacity and automated instruments. Single cell and sub-cellular analyses continue to progress in CE because of the size compatibility of the technique with the sample. Other examples of areas utilizing CE that are accelerating include portable and printable instrumentation, affinity interaction, as well as proteomics. As an established analytical tool, CE instrumentation and methods have been designed to be accessible and easily adopted by researchers with expertise in areas beyond the field of separations. Generally, publications including CE measurements either outline innovations in the technique or they are compelling applications of a mature analytical approach. The goal of this review, which is limited to 180 citations, is

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Section: Pharmaceuticalsmentioning

confidence: 99%

Section: Pharmaceuticalsmentioning

confidence: 99%

Challenging Bioanalyses with Capillary Electrophoresis

et al. 2019

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“…In this situation, chiral ionic liquids (CILs) were important for significantly improving the CE enantioseparation. Otherwise, DES are eutectic systems formed from a mixture of Lewis or Brønsted acids and bases, and only more recently, in 2019, DESs were used in CE for chiral separation [35]. In the literature, works are also dedicated to reviewing the use of IL and DES in CE [11,36,37].…”

Section: A Short History Of Electromigration Techniques For Enantiose...mentioning

confidence: 99%

“…DES is attracting much attention for CE as chiral selectors or even as additives in CD-based systems, improving the enantiomeric resolution [163]. Further relevant applications are summarized in Table 3 [35,[163][164][165][166].…”

Section: 13mentioning

confidence: 99%

From capillaries to microchips, green electrophoretic features for enantiomeric separations: A decade review (2013–2022)

Aredes,

Lima,

Faillace

et al. 2023

Electrophoresis

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Enantioseparation by the electromigration‐based method is well‐established and widely discussed in the literature. Electrophoretic strategies have been used to baseline resolve complex enantiomeric mixtures, typically using a selector substance into the background electrolyte (BGE) from capillaries to microchips. Along with developing new materials/substances for enantioseparations, it is the concern about the green analytical chemistry (GAC) principles for method development and application. This review article brings a last decade's update on the publications involving enantioseparation by electrophoresis for capillary and microchip systems. It also brings a critical discussion on GAC principles and new green metrics in the context of developing an enantioseparation method. Chemical and green features of native and modified cyclodextrins are discussed. Still, given the employment of greener substances, ionic liquids and deep‐eutectic solvents are highlighted, and some new selectors are proposed. For all the mentioned selectors, green features about their production, application, and disposal are considered. Sample preparation and BGE composition in GAC perspective, as well as greener derivatization possibilities, were also addressed. Therefore, one of the goals of this review is to aid the electrophoretic researchers to look where they have not.

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“…Recently chiral ILs have been the focus of an intense interest as additives for their synergistic effect on CD-driven enantioseparations [ 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 ], and in some instances, for functionalization of the CDs [ 113 , 114 ]. The synergistic effect on the chiral separation by CDs has recently been reported by the utilization of eutectic solvents [ 115 , 116 , 117 ].…”

Section: Recent Advances In the Development Of Ce Analytical Procedur...mentioning

confidence: 99%

New Trends in the Quality Control of Enantiomeric Drugs: Quality by Design-Compliant Development of Chiral Capillary Electrophoresis Methods

et al. 2022

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Capillary electrophoresis (CE) is a potent method for analyzing chiral substances and is commonly used in the enantioseparation and chiral purity control of pharmaceuticals from different matrices. The adoption of Quality by Design (QbD) concepts in analytical method development, optimization and validation is a widespread trend observed in various analytical approaches including chiral CE. The application of Analytical QbD (AQbD) leads to the development of analytical methods based on sound science combined with risk management, and to a well understood process clarifying the influence of method parameters on the analytical output. The Design of Experiments (DoE) method employing chemometric tools is an essential part of QbD-based method development, allowing for the simultaneous evaluation of experimental parameters as well as their interaction. In 2022 the International Council for Harmonization (ICH) released two draft guidelines (ICH Q14 and ICH Q2(R2)) that are intended to encourage more robust analytical procedures. The ICH Q14 guideline intends to harmonize the scientific approaches for analytical procedures’ development, while the Q2(R2) document covers the validation principles for the use of analytical procedures including the recent applications that require multivariate statistical analyses. The aim of this review is to provide an overview of the new prospects for chiral CE method development applied for the enantiomeric purity control of pharmaceuticals using AQbD principles. The review also provides an overview of recent research (2012–2022) on the applicability of CE methods in chiral drug impurity profiling.

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Investigation of deep eutectic solvents as additives to β‐CD for enantiomeric separations of Zopiclone, Salbutamol, and Amlodipine by CE

Cited by 36 publications

References 14 publications

Challenging Bioanalyses with Capillary Electrophoresis

Challenging Bioanalyses with Capillary Electrophoresis

From capillaries to microchips, green electrophoretic features for enantiomeric separations: A decade review (2013–2022)

New Trends in the Quality Control of Enantiomeric Drugs: Quality by Design-Compliant Development of Chiral Capillary Electrophoresis Methods

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