Investigation of diabetes mellitus in Burmese cats as an inherited trait: a preliminary study

O’Leary, C. A.; Duffy, David L.; Gething, M.A.; McGuckin, Carrie; Rand, J. S.

doi:10.1080/00480169.2013.817295

Cited by 13 publications

(10 citation statements)

References 27 publications

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“…For example, it is possible that the high prevalence of diabetes in pure bred Burmese cats from catteries in Europe and Australia is an unintended outcome of selective breeding since Burmese breed has not been identified as a diabetes risk factor in the U.S. feline population (132, 133). Although the genetic basis for the difference between the two Burmese cat populations is not known, the observation serves to illustrate both the ability of selective breeding to alter metabolic traits over relatively few generations and a possible pitfall when attempting to extrapolate research from a domestic carnivore to the larger group of non-domesticated carnivores (134). …”

Section: Impact Of Domestication and Captivity On Carnivore Carbohydrmentioning

confidence: 99%

Normal Glucose Metabolism in Carnivores Overlaps with Diabetes Pathology in Non-Carnivores

Schermerhorn

2013

Front. Endocrinol.

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Carnivores, such as the dolphin and the domestic cat, have numerous adaptations that befit consumption of diets with high protein and fat content, with little carbohydrate content. Consequently, nutrient metabolism in carnivorous species differs substantially from that of non-carnivores. Important metabolic pathways known to differ between carnivores and non-carnivores are implicated in the development of diabetes and insulin resistance in non-carnivores: (1) the hepatic glucokinase (GCK) pathway is absent in healthy carnivores yet GCK deficiency may result in diabetes in rodents and humans, (2) healthy dolphins and cats are prone to periods of fasting hyperglycemia and exhibit insulin resistance, both of which are risk factors for diabetes in non-carnivores. Similarly, carnivores develop naturally occurring diseases such as hemochromatosis, fatty liver, obesity, and diabetes that have strong parallels with the same disorders in humans. Understanding how evolution, environment, diet, and domestication may play a role with nutrient metabolism in the dolphin and cat may also be relevant to human diabetes.

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Section: Impact Of Domestication and Captivity On Carnivore Carbohydrmentioning

confidence: 99%

Normal Glucose Metabolism in Carnivores Overlaps with Diabetes Pathology in Non-Carnivores

Schermerhorn

2013

Front. Endocrinol.

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“…Similar observations have been made of Burmese cats in Australia [ 7 , 8 ] and Sweden [ 9 ]; and recent studies suggest that this is due to dysregulation of lipid metabolism in this breed [ 10 , 11 ]. A recent pilot study suggests involvement of a major gene locus in diabetes in Burmese cats [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

An individual approach to feline diabetes care: a case report and literature review

2016

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BackgroundAchieving insulin independence is emerging as a realistic therapeutic goal in the management of feline diabetes mellitus.Case presentationThe management of an 11-year-old spayed female Burmese cat presenting with diabetes mellitus after corticosteroid administration is described. Remission was achieved after the frequency of insulin administration was increased to four times a day, and supported by intensive home blood glucose monitoring and a high protein, low carbohydrate diet.ConclusionOwners are important collaborators in feline diabetes care and, with intensive home monitoring, more frequent insulin treatment may lead to remission without hypoglycemia. More frequent insulin injections than recommended in the literature may be necessary to achieve glycemic control and used as an alternative to a longer-acting insulin.

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“…However, it is highly probable that the gene or genes involved are autosomal rather than sex-linked, as both male and female cats were affected in this case series. 7 …”

Section: Discussionmentioning

confidence: 99%

“…The Burmese is now one of the most genetically inbred cat populations worldwide, 3 and has been over-represented in a number of conditions, including frontonasal dysplasia (Burmese head defect), feline orofacial pain syndrome, 4 hypokalaemic polymyopathy, 5 diabetes mellitus, 6 , 7 cutaneous asthaenia, 8 endocardial fibroelastosis, 9 primary glaucoma 10 and GM2 gangliosidosis. 11 Genetic tests are available for GM2 gangliosidosis, 11 Burmese hypokalaemia 5 and Burmese head defect.…”

Section: Introductionmentioning

confidence: 99%

Supernumerary maxillary fourth premolar teeth in five related Burmese cats

Emslie¹,

Tutt²

2020

Journal of Feline Medicine and Surgery Open Reports

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Case series summary This article reports a case series of five Burmese cats with supernumerary teeth. All included cases displayed either unilateral or bilateral supernumerary maxillary fourth premolar teeth. Two cases also displayed supernumerary mandibular fourth premolar teeth, and in one case bilateral supernumerary maxillary third incisor teeth were found. Examination of the pedigrees of the affected cats revealed that all five cats were related with one common ancestor. All patients in this case series were successfully treated. Relevance and novel information Supernumerary maxillary fourth premolar teeth in cats have not been reported previously in the literature. As all five cats in this case series were shown to be related, supernumerary maxillary fourth premolar teeth may be yet another heritable health condition affecting the Burmese breed. Therefore, Burmese breeders should endeavour to reduce the incidence of supernumerary teeth within the breed by having animals examined by a veterinary dentist prior to breeding, and neutering affected, as well as related, individuals. Burmese cat owners must be made aware of the condition in order to institute early evaluation, diagnosis and treatment.

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Investigation of diabetes mellitus in Burmese cats as an inherited trait: a preliminary study

Cited by 13 publications

References 27 publications

Normal Glucose Metabolism in Carnivores Overlaps with Diabetes Pathology in Non-Carnivores

Normal Glucose Metabolism in Carnivores Overlaps with Diabetes Pathology in Non-Carnivores

An individual approach to feline diabetes care: a case report and literature review

Supernumerary maxillary fourth premolar teeth in five related Burmese cats

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