Investigation of distribution laws of the phase difference of the envelopes of electromyograms of antagonist muscles in Parkinson's disease and essential tremor patients

Sushkova, Olga S.; Morozov, Alexei A.; Kershner, Ivan A.; Petrova, Nadezhda G.; Gabova, Alexandra V.; Chigaleychik, Larisa A.; Karabanov, Alexander

doi:10.17725/rensit.2020.12.415

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…The method developed for analyzing the wave train electrical activity is a universal method for exploratory data analysis and can be applied to other types of biomedical signals [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ]. In particular, we demonstrated that the statistical analysis of some characteristics of wave trains in EEG can identify features of the preclinical stage of PD [ 58 , 59 , 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

A Statistical Method for Exploratory Data Analysis Based on 2D and 3D Area under Curve Diagrams: Parkinson’s Disease Investigation

Sushkova

Morozov

Gabova

et al. 2021

Sensors

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A statistical method for exploratory data analysis based on 2D and 3D area under curve (AUC) diagrams was developed. The method was designed to analyze electroencephalogram (EEG), electromyogram (EMG), and tremorogram data collected from patients with Parkinson’s disease. The idea of the method of wave train electrical activity analysis is that we consider the biomedical signal as a combination of the wave trains. The wave train is the increase in the power spectral density of the signal localized in time, frequency, and space. We detect the wave trains as the local maxima in the wavelet spectrograms. We do not consider wave trains as a special kind of signal. The wave train analysis method is different from standard signal analysis methods such as Fourier analysis and wavelet analysis in the following way. Existing methods for analyzing EEG, EMG, and tremor signals, such as wavelet analysis, focus on local time–frequency changes in the signal and therefore do not reveal the generalized properties of the signal. Other methods such as standard Fourier analysis ignore the local time–frequency changes in the characteristics of the signal and, consequently, lose a large amount of information that existed in the signal. The method of wave train electrical activity analysis resolves the contradiction between these two approaches because it addresses the generalized characteristics of the biomedical signal based on local time–frequency changes in the signal. We investigate the following wave train parameters: wave train central frequency, wave train maximal power spectral density, wave train duration in periods, and wave train bandwidth. We have developed special graphical diagrams, named AUC diagrams, to determine what wave trains are characteristic of neurodegenerative diseases. In this paper, we consider the following types of AUC diagrams: 2D and 3D diagrams. The technique of working with AUC diagrams is illustrated by examples of analysis of EMG in patients with Parkinson’s disease and healthy volunteers. It is demonstrated that new regularities useful for the high-accuracy diagnosis of Parkinson’s disease can be revealed using the method of analyzing the wave train electrical activity and AUC diagrams.

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Section: Discussionmentioning

confidence: 99%

A Statistical Method for Exploratory Data Analysis Based on 2D and 3D Area under Curve Diagrams: Parkinson’s Disease Investigation

Sushkova

Morozov

Gabova

et al. 2021

Sensors

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“…We applied the method developed earlier for the analysis of the wave train electrical activity [ 42 , 47 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ] to analyze the local maxima in the cross-wavelet spectra. The method is based on the use of 2D and 3D AUC diagrams.…”

Section: Auc Diagrams Based On Cross-wavelet Spectramentioning

confidence: 99%

“…Phase analysis is widely used in biomedical research [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. The Hilbert transform and complex wavelets are usually used for computing the instantaneous phase [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Phase Shifts Using AUC Diagrams: Application to Differential Diagnosis of Parkinson’s Disease and Essential Tremor

Sushkova

Morozov

Kershner

et al. 2023

Sensors

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This study was motivated by the well-known problem of the differential diagnosis of Parkinson’s disease and essential tremor using the phase shift between the tremor signals in the antagonist muscles of patients. Different phase shifts are typical for different diseases; however, it remains unclear how this parameter can be used for clinical diagnosis. Neurophysiological papers have reported different estimations of the accuracy of this parameter, which varies from insufficient to 100%. To address this issue, we developed special types of area under the ROC curve (AUC) diagrams and used them to analyze the phase shift. Different phase estimations, including the Hilbert instantaneous phase and the cross-wavelet spectrum mean phase, were applied. The results of the investigation of the clinical data revealed several regularities with opposite directions in the phase shift of the electromyographic signals in patients with Parkinson’s disease and essential tremor. The detected regularities provide insights into the contradictory results reported in the literature. Moreover, the developed AUC diagrams show the potential for the investigation of neurodegenerative diseases related to the hyperkinetic movements of the extremities and the creation of high-accuracy methods of clinical diagnosis.

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“…Low-frequency oscillations in trapezius muscle EMG have been suggested as a tool to study neural mechanisms including slow-wave cortical oscillations represented in the descending corticospinal pathways and monoaminergic pathways originating in brain stem reticular formation [33]. Consequently, the 0.5-4 Hz range has revealed neurophysiological regularities in patients with Parkinson's disease [34] suggesting the possibility for improved diagnostic capabilities of cognitive functioning. Additionally, the 6-12 Hz frequency range has been associated with differing parts of the brain, including the cerebellar [35], subcortical [36], sensorimotor cortex [37], and primary motor cortex [38].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Analysis of Trapezius Muscle EMG Activity in Relation to Stress and Meditation

Ahmed,

Grillo,

Taebi

et al. 2024

BioMedInformatics

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Introduction: This study analyzes the efficacy of trapezius muscle electromyography (EMG) in discerning mental states, namely stress and meditation. Methods: Fifteen healthy participants were monitored to assess their physiological responses to mental stressors and meditation. Sensors were affixed to both the right and left trapezius muscles to capture EMG signals, while simultaneous electroencephalography (EEG) was conducted to validate cognitive states. Results: Our analysis of various EMG features, considering frequency ranges and sensor positioning, revealed significant changes in trapezius muscle activity during stress and meditation. Notably, low-frequency EMG features facilitated enhanced stress detection. For accurate stress identification, sensor configurations can be limited to the right trapezius muscle. Furthermore, the introduction of a novel method for determining asymmetry in EMG features suggests that applying sensors on bilateral trapezius muscles can improve the detection of mental states. Conclusion: This research presents a promising avenue for efficient cognitive state monitoring through compact and convenient sensing.

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Investigation of distribution laws of the phase difference of the envelopes of electromyograms of antagonist muscles in Parkinson's disease and essential tremor patients

Cited by 5 publications

References 16 publications

A Statistical Method for Exploratory Data Analysis Based on 2D and 3D Area under Curve Diagrams: Parkinson’s Disease Investigation

A Statistical Method for Exploratory Data Analysis Based on 2D and 3D Area under Curve Diagrams: Parkinson’s Disease Investigation

Investigation of Phase Shifts Using AUC Diagrams: Application to Differential Diagnosis of Parkinson’s Disease and Essential Tremor

A Comprehensive Analysis of Trapezius Muscle EMG Activity in Relation to Stress and Meditation

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