Investigation of DNA binding and bioactivities of thioether containing Schiff base Copper(II), Cobalt(II) and Palladium(II) complexes: Synthesis, characterization, spectrochemical study, viscosity measurement

Maiti, Subir Kr; Kalita, Mukul; Singh, Anmol; Deka, Jahnabi; Barman, Pranjit

doi:10.1016/j.poly.2020.114559

Cited by 51 publications

(15 citation statements)

References 35 publications

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“…These complexes also interfere with the respiratory process of the cell so that it inhibits the synthesis of the protein that regulates the further growth of the organism. Also, the normal cell process is affected by the formation of hydrogen bonds, by the amino group with the active centers of the cell components, [ 23 ] thereby destroying them more aggressively.…”

Section: Resultsmentioning

confidence: 99%

“…So as to compare the binding strengths of the synthesized metal complexes quantitatively, the binding constants ( K b ) of all the complexes with CT‐DNA were obtained by monitoring the changes in the absorbance at their respective absorption bands, with increasing concentration of CT‐DNA with the following equation. [ 22,23 ]

([], DNA) / ((), italicεa - italicεf) = ([], DNA) / ((), italicεb - italicεf) + 1 / italicKb ((), italicεb - italicεf)

The terms, ɛ a , ɛ f , and ɛ b are the apparent, free, and fully DNA‐bound compound absorption coefficients, respectively, and [DNA] is the concentration of DNA base pairs. [ 8 ] Intrinsic binding constant K b , the ratio of slope to intercept, is calculated from the plot of [DNA]/( ε a − ε f ) versus [DNA].…”

Section: Methodsmentioning

confidence: 99%

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Investigation of DNA binding and bioactivities of furan cored Schiff base Cu (II), Ni (II), and Co (III) complexes: Synthesis, characterization and spectroscopic properties

Venkateswarlu

Daravath

Ramesh

et al. 2021

Applied Organom Chemis

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Novel binary metal complexes, 1 [Cu(FMIMBMOP)2], 2 [Ni(FMIMBMOP)2] and 3 [Co(FMIMBMOP)3], where FMIMBMOP (2‐((E)‐((furan‐2‐yl)methylimino)methyl)‐4‐bromo‐6‐methoxyphenol), were synthesized and characterized using different analytical techniques. Result of spectral studies reveals that square planar geometry is assigned for Cu (II) and Ni (II) complexes, whereas octahedral geometry is assigned for Co (III) complex. The thermodynamic and kinetic parameters for the degradation of the complexes were ascertained by Coats–Redfern method for thermogravimetric data attained from thermogravimetric analysis (TGA). The stability of the complexes has been calculated from quantum chemical parameters using highest occupied molecular orbital (HOMO)–lowest unoccupied molecular orbital (LUMO) energies. The DNA binding of complexes was studied by using ultraviolet–visible (UV–Vis) spectroscopic technique; screening their ability to bind to calf thymus DNA (CT‐DNA) showed that the complexes can interact with CT‐DNA through intercalation mood, where the Kb values are 2.59 ± 0.01 × 104, 7.43 ± 0.03 × 103, and 6.73 ± 0.02 × 104 M−1 for 1, 2, and 3, respectively. Stern–Volmer quenching constant (Ksv) values ranged from 2.32 ± 0.03 × 103 to 1.66 ± 0.02 × 104 M−1 were calculated for complexes from fluorescence studies. The oxidative and photolytic cleavage of supercoiled pBR322 DNA was studied and found that the complexes have cleaved this DNA effectively. The novel metal complexes have shown significant antioxidant activity against DPPH radical. The antibacterial activity of Schiff base and its metal complexes screened against Bacillus thuringiensis, Streptococcus pneumoniae, Escherichia coli, and Pseudomonas putida was investigated, and the results indicated that the metal complexes have better results than Schiff base ligand. The catalytic ability of metal complexes 1, 2, and 3 was found to be 3 > 1 > 2.

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Section: Resultsmentioning

confidence: 99%

([], DNA) / ((), italicεa - italicεf) = ([], DNA) / ((), italicεb - italicεf) + 1 / italicKb ((), italicεb - italicεf)

Section: Methodsmentioning

confidence: 99%

Investigation of DNA binding and bioactivities of furan cored Schiff base Cu (II), Ni (II), and Co (III) complexes: Synthesis, characterization and spectroscopic properties

Venkateswarlu

Daravath

Ramesh

et al. 2021

Applied Organom Chemis

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“…[ 2 ] The functionality of the coordination ability of Schiff bases to metal ions arises from their importance in various biological aspects, such as growth inhibiting agents for most types of microbial agents. [ 3 ] Therefore, Schiff base metal chelates play a significant role in the development of the branch of bio coordination chemistry. Further, Schiff bases comprising heterocyclic moieties have gained more attention due to their ability to bind multiple biological targets.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic and thermal studies of Cu⁺², Ni⁺²and Co⁺³complexes of Schiff base containing furan moiety. Antitumor, antioxidant, antibacterial and DNA interaction studies

Venkateswarlu

Lakshmi

Shivaraj

2021

Applied Organom Chemis

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Three mononuclear bioefficient imine‐based coordination complexes [Cu(FMIMBCP)2] (1), [Ni(FMIMBCP)2] (2), and [Co(FMIMBCP)3] (3) were synthesized using ligand [FMIMBCP = (((furan‐2‐yl)methylimino)methyl)‐6‐bromo‐4‐chlorophenol]. The formation of the complexes was ascertained by elemental analysis, Fourier transform infrared, UV–Visible, electrospray‐mass spectrometry, electron paramagnetic resonance, and thermogravimetric analysis. From the thermogravimetric curves, the kinetic and thermodynamic parameters of the thermal degradation steps were computed. The stability of the complexes has been calculated from quantum chemical parameters using HOMO‐LUMO energies. The comparative binding propensity profiles of above synthesized complexes with the calf thymus‐DNA were investigated via UV absorption and fluorescence studies. On the basis of extended conjugation and increased chromophores, complex 3 exhibited superior bioactivity with greater calculated DNA binding constant values, (Kb) 5.73 × 104 M−1 (3) as compared to complexes 1 (2.96 × 104 M−1) and 2 (8.38 × 103 M−1). The competitive binding titration with ethidium bromide (EB) revealed that metal complexes efficiently displace EB from the EB‐DNA system. The complexes were found to have pronounced cleavage efficiency as evaluated from agarose gel electrophoresis. The anticancer activity of the ligand and metal complexes against MCF‐7 and KB3 cells revealed that the complexes were more efficacious than the corresponding ligand. Further, in vitro antioxidant activity against DPPH proclaimed the remarkable bioefficiency of compounds, which makes them promising as an active chemotherapeutic agent. The complexes have strong antibacterial activity against Bacillus thuringiensis, Streptococcus pneumoniae, Escherichia coli, and Pseudomonas putida.

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“…C=C- and C–H bands are found at 1400 and 1600 cm –1 as well as 3000 cm –1 , respectively and are in the expected ranges for ruthenium(II) complexes [ 34 , 35 ]. The dominant band at 742–748 cm –1 derived from thioether S–C parts of the prepared complexes [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Arene Ruthenium(II) Complexes Bearing the κ-P or κ-P,κ-S Ph2P(CH2)3SPh Ligand

et al. 2021

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Neutral [Ru(η6-arene)Cl2{Ph2P(CH2)3SPh-κP}] (arene = benzene, indane, 1,2,3,4-tetrahydronaphthalene: 2a, 2c and 2d) and cationic [Ru(η6-arene)Cl(Ph2P(CH2)3SPh-κP,κS)]X complexes (arene = mesitylene, 1,4-dihydronaphthalene; X = Cl: 3b, 3e; arene = benzene, mesitylene, indane, 1,2,3,4-tetrahydronaphthalene, and 1,4-dihydronaphthalene; X = PF6: 4a–4e) complexes were prepared and characterized by elemental analysis, IR, 1H, 13C and 31P NMR spectroscopy and also by single-crystal X-ray diffraction analyses. The stability of the complexes has been investigated in DMSO. Complexes have been assessed for their cytotoxic activity against 518A2, 8505C, A253, MCF-7 and SW480 cell lines. Generally, complexes exhibited activity in the lower micromolar range; moreover, they are found to be more active than cisplatin. For the most active ruthenium(II) complex, 4b, bearing mesitylene as ligand, the mechanism of action against 8505C cisplatin resistant cell line was determined. Complex 4b induced apoptosis accompanied by caspase activation.

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Investigation of DNA binding and bioactivities of thioether containing Schiff base Copper(II), Cobalt(II) and Palladium(II) complexes: Synthesis, characterization, spectrochemical study, viscosity measurement

Cited by 51 publications

References 35 publications

Investigation of DNA binding and bioactivities of furan cored Schiff base Cu (II), Ni (II), and Co (III) complexes: Synthesis, characterization and spectroscopic properties

Investigation of DNA binding and bioactivities of furan cored Schiff base Cu (II), Ni (II), and Co (III) complexes: Synthesis, characterization and spectroscopic properties

Synthesis, spectroscopic and thermal studies of Cu⁺², Ni⁺²and Co⁺³complexes of Schiff base containing furan moiety. Antitumor, antioxidant, antibacterial and DNA interaction studies

Arene Ruthenium(II) Complexes Bearing the κ-P or κ-P,κ-S Ph2P(CH2)3SPh Ligand

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Investigation of DNA binding and bioactivities of thioether containing Schiff base Copper(II), Cobalt(II) and Palladium(II) complexes: Synthesis, characterization, spectrochemical study, viscosity measurement

Cited by 51 publications

References 35 publications

Investigation of DNA binding and bioactivities of furan cored Schiff base Cu (II), Ni (II), and Co (III) complexes: Synthesis, characterization and spectroscopic properties

Investigation of DNA binding and bioactivities of furan cored Schiff base Cu (II), Ni (II), and Co (III) complexes: Synthesis, characterization and spectroscopic properties

Synthesis, spectroscopic and thermal studies of Cu+2, Ni+2and Co+3complexes of Schiff base containing furan moiety. Antitumor, antioxidant, antibacterial and DNA interaction studies

Arene Ruthenium(II) Complexes Bearing the κ-P or κ-P,κ-S Ph2P(CH2)3SPh Ligand

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Synthesis, spectroscopic and thermal studies of Cu⁺², Ni⁺²and Co⁺³complexes of Schiff base containing furan moiety. Antitumor, antioxidant, antibacterial and DNA interaction studies