Investigation of dopamine receptors in susceptibility to behavioural and psychological symptoms in Alzheimer's disease

Abstract

Our data, in combination with a review of the literature, reveal a potential role for the VNTR variant of DRD4 in the development of depression in AD patients. The findings presented here need to be replicated in large, well characterised longitudinal cohorts.

Assessment of curated phenotype mining in neuropsychiatric disorder literature

“…DRD2 is one of four genes coding for dopamine receptors, and while DRD3 and DRD4 have been associated with AD, DRD2 so far was not. Our results support the association of this gene with non-cognitive symptoms of AD [19,20]. MAG encodes the myelin-associated glycoprotein; its association with AD has been recently investigated with negative results [21].…”

Specific Agonists and Antagonists of Serotonergic Receptors in theTreatment of Cognitive Symptoms in Alzheimer's Disease

“…Polymorphisms of the dopaminergic receptors were examined in Alzheimer patients with aggression. Polymorphisms of polymorphisms of the D3 and D4 receptors could be found in Alzheimer patients with agression [9].…”

Catechol-O-Methyltransferase GeneticVariant Associated with the Risk of Alzheimer’s Disease in a Brazilian Population

“…It is well established that AD is a heterogeneous disease characterized by a variety of BPSD beyond the well-known progressive cognitive decline [6,7,36]. Different clinical phenotypes might be influenced by underlying genetic variability and behavioral and psychological symptoms.…”

“…ed with considerable morbidity for patients and distress for caregivers [6,7]. A genetic predisposition to BPSD in AD has been proposed in family studies [8].…”