Investigation of drug-induced hepatopathy by folk medicine and by health food.

Agaricus blazei Murill (ABM) is one of the most popular complementary alternative medicines (CAM). We experienced a case of a 60-year-old woman with severe hepatitis associated with extract of ABM and extract of Ganoderma lucidum, and a case of a 75-year-old man with drug-induced liver injury (DILI) associated with extract of ABM and fucoidan. Their clinical courses from the start of CAM until the onset of DILI were observed unexpectedly, because they were under observation for stable malignant neoplasms: stage III malignant thymoma and stage IV lung cancer, respectively. However, they did not talk about taking CAM with their physicians. There were two common points between these two cases. First, they were diagnosed as compatible with DILI by using an international diagnostic scale, the Roussel Uclaf Causality Assessment Method. The second point was that histological findings of the liver were very similar to autoimmune hepatitis (AIH). In addition, serum immunoglobulin G and zinc sulfate turbidity tests gradually increased from the start of CAM to the onset of DILI. Their clinical course and liver histology suggested that the immunostimulating action of ABM caused liver injury which was very similar to that seen in AIH.

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Drug-induced liver injury associated with Agaricus blazei Murill which is very similar to autoimmune hepatitis

Hisamochi

Kage

Arinaga

et al. 2013

Clin J Gastroenterol

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Clinical characteristics of drug‐induced liver injury in the elderly

Onji

Fujioka

Takeuchi

et al. 2009

Hepatology Research

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Do the national survey results reflect the state of drug‐induced liver injury in a single local city in which there is no hospital having Members of the Board of Councilors of the Japan Society of Hepatology? Results of a questionnaire survey conducted in a local city

Hisamochi

Kumashiro

Sata

2011

Hepatology Research

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This survey revealed that the results of the national investigations conducted by the Japan Society of Hepatology (JSH) reflect the current state of DILI in local areas in which there is no hospital with Members of the Board of Councilors of the JSH. Widespread utilization of the Manual and JDDW scale by local doctors must be facilitated for early diagnosis of DILI and the prevention of severe conditions.

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Investigation of drug-induced hepatopathy by folk medicine and by health food.

Cited by 14 publications

References 10 publications

Drug-induced liver injury associated with Agaricus blazei Murill which is very similar to autoimmune hepatitis

Drug-induced liver injury associated with Agaricus blazei Murill which is very similar to autoimmune hepatitis

Clinical characteristics of drug‐induced liver injury in the elderly

Do the national survey results reflect the state of drug‐induced liver injury in a single local city in which there is no hospital having Members of the Board of Councilors of the Japan Society of Hepatology? Results of a questionnaire survey conducted in a local city

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