Investigation of effects of different treatment modalities on structural and functional vessel wall properties in patients with ankylosing spondylitis

Çapkın, Erhan; Kırış, Abdülkadir; Karkucak, Murat; Durmuş, İsmet; Gökmen, Ferhat; Cansu, Ayşegül; Tosun, Mehmet; Ayar, Ahmet

doi:10.1016/j.jbspin.2010.09.023

Cited by 36 publications

(33 citation statements)

References 21 publications

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“…Therefore, studies particularly use pre-treatment values as reference (relying on stated disease impact) and investigate the effect of the therapy protocol on these baseline values, 8,23 as in the current study. As it is already established and documented by researchers 23 including our group, 13 PWV is higher in AS patients than in the control group. But this is not critical for the outcome of this study since the main aim was not to investigate whether the PWV values of AS patients are different from the healthy population, but rather to investigate the possible beneficial effect of anti-TNF-a therapy on the arterial stiffness as indicated by PWV.…”

Section: Discussionsupporting

confidence: 84%

“…8 Anti-TNF-a therapy has been associated with dramatic improvements in the clinical signs and symptoms of AS. 13 Previously, we published the results for a 24-week follow-up of anti-TNF-a therapy in the same patient population, which indicated no beneficial effect on arterial stiffness. 8 In addition to the fact that vascular structural changes may require longer time, the optimal follow-up period for observing the effects of anti-TNF-a therapy on arterial stiffness remains unknown, and longer-term consequences are still unclear.…”

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confidence: 97%

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Arterial Stiffness and Anti-Tumor Necrosis Factor-Alpha Therapy in Ankylosing Spondylitis: Results With Long-Term Two Year-Follow-Up

et al. 2014

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Objectives: This prospective clinical study aims to evaluate the effectiveness of long-term of anti-tumor necrosis factor-alpha (TNF-a) therapy on arterial stiffness in ankylosing spondylitis. Patients and methods: A total of 28 active ankylosing spondylitis patients (21 males, 7 females; mean age 33.5±9.5 years; range 20 to 52 years) were enrolled. Patients' values for before the initiation of biological therapy and mid-term (24 weeks) evaluation were reported. For further evaluation, this initially reported patients were contacted two years after anti-TNF-α therapy, and their arterial stiffness was assessed by using pulse wave velocity. Results: After two years of anti-TNF-α therapy, despite the significant improvements in patients' symptoms and clinical activity parameters including Bath Ankylosing Spondylitis Disease Activity Index score (4.9±0.9, 1.9±0.5 and 1.8±0.9, p=0.0001), erythrocyte sedimentation rate (35.5±23.1 mm/h, 13.8±9.2 mm/h and 25.0±17.9 mm/h, p=0.0001), and C-reactive protein (2.1±1.6 ng/dL, 0.4±0.3 ng/dL and 0.6±0.9 ng/dL p=0.0001), no significant difference was observed in arterial stiffness parameters (7.9±1.3 meter/second, 7.7±1.3 meter/second and 8.3±1.1 meter/second, p=0.620). Conclusion:In line with the previous 24-week evaluation, the results at two-year follow-up indicates that anti-TNF-α therapy does not improve arterial stiffness in patients with ankylosing spondylitis.

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Section: Discussionsupporting

confidence: 84%

mentioning

confidence: 97%

Arterial Stiffness and Anti-Tumor Necrosis Factor-Alpha Therapy in Ankylosing Spondylitis: Results With Long-Term Two Year-Follow-Up

et al. 2014

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“…[12] и противоречит исследованию I. J. Berg и соавт., в котором было по-казано повышение индекса аугментации при отсут-ствии ускорения скорости распространения пульсовой волны у пациентов с АС, несмотря на то, что этот по-казатель является признанным фактором сердечно-со-судистого риска [13]. В ряде работ показано повыше-ние СРПВao у больных АС до лечения при отсутствии изменений жесткости сосудистой стенки во время терапии НПВП и ингибиторами ФНО-α [14,15]. Сле-дует отметить, что наши пациенты получали НПВП в непрерывном режиме, в то время как в обсуждаемой работе I. J. Berg выполнялось лечение биологическими агентами, действие которых на сосудистую стенку нуждается в уточнении: в некоторых работах показано негативное влияние и/или отсутствие положительного влияния биологических агентов на эндотелий и его функции [16,17].…”

Section: результатыunclassified

“…Также установлено, что менее лабильный во времени (в от-личие от ВЧСРБ) показатель -индекс BASMI -по-казал значимую взаимосвязь с показателями жестко-сти сосудистой стенки, что согласуется с данными E. Capkin и соавт. [14]. Стойкие во времени функцио-нальные индексы, возможно, смогут в дальнейшем применяться для оценки кардиоваскулярного риска в популяции больных АС, так как являются отражени-ем суммарного воздействия персистирующего воспа-ления на организм человека за длительный период времени.…”

Section: результатыunclassified

Vascular Wall Stiffness in Patients With Ankylosing Spondylitis: Results of a Multicenter Study

et al. 2015

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“…In this era of effective treatments for rheumatic diseases, such as biologics, attention is focused on feasible therapy monitoring techniques. US and PDUS seem to be among the most promising modalities for monitoring the efficacy of treatments for rheumatic diseases (48)(49)(50).…”

Section: Power Doppler Us For Evaluating Treatment Response In Rheumamentioning

confidence: 99%

Doppler US in rheumatic diseases with special emphasis on rheumatoid arthritis and spondyloarthritis

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Kılıç

Serter³

et al. 2013

Diagn Interv Radiol

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Developments in digital ultrasonography (US) technology and the use of high-frequency broadband transducers have increased the quality of US imaging, particularly of superficial tissues. Thus, US, particularly color US or power Doppler US, in which high-resolution transducers are used, has become an important imaging modality in the assessment of rheumatic diseases. Furthermore, therapeutic interventions and biopsies can be performed under US guidance during the assessment of lesions. In this era of effective treatments, such as biologics, improvements in synovial inflammation in rheumatoid arthritis as well as changes in enthesitis in spondyloarthropathies, including ankylosing spondylitis and psoriatic arthritis, can be monitored effectively using gray-scale and/ or power Doppler US. US is also a good imaging modality for crystal arthropathies, including gout and pseudogout, in which synovitis, erosions, tophi, and crystal deposition within or around the joint can be visualized readily. Vascular and tenosynovial structures, as well as the salivary glands, can be assessed with US in vasculitis and connective tissue disorders, including systemic lupus erythematosus and Sjögren's syndrome. Current research is focused on improving the sensitivity, specificity, validity, and reproducibility of US findings. In this review, we summarized the role of US, particularly power Doppler US, in rheumatic diseases and inflammation in superficial tissues.

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Investigation of effects of different treatment modalities on structural and functional vessel wall properties in patients with ankylosing spondylitis

Cited by 36 publications

References 21 publications

Arterial Stiffness and Anti-Tumor Necrosis Factor-Alpha Therapy in Ankylosing Spondylitis: Results With Long-Term Two Year-Follow-Up

Arterial Stiffness and Anti-Tumor Necrosis Factor-Alpha Therapy in Ankylosing Spondylitis: Results With Long-Term Two Year-Follow-Up

Vascular Wall Stiffness in Patients With Ankylosing Spondylitis: Results of a Multicenter Study

Doppler US in rheumatic diseases with special emphasis on rheumatoid arthritis and spondyloarthritis

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