Investigation of effects of short‐term exposure to 50 HZ magnetic field on central, peripheral, and autonomic nervous systems in rats

Elmas, Onur; Çömlekçi, Selçuk

doi:10.1002/bem.21922

Cited by 2 publications

(2 citation statements)

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“…It is generally accepted that general anaesthesia reduces HRV, which cannot be relevantly assessed from our analysis because there are few studies involving female rats; however, it is clear from the results that parasympathetic activity dominated in females under ketamine/xylazine (Gonçalves et al, 2010;Elmas & Comlekci, 2015;Svorc et al, 2014) as well as under pentobarbital anaesthesia (Svorc et al, 2015).…”

Section: Sex and Chronobiology Of Hrv Under General Anaesthesiamentioning

confidence: 99%

Sex differences, chronobiology and general anaesthesia in activities of the autonomic nervous system in rats

Švorc

Grešová

2023

Experimental Physiology

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New Findings What is the topic of this review?Changes in heart rate variability in rats with sex differences and the use of different anaesthesia during light–dark cycles. What advances does it highlight?The review highlights and discusses synthesized current results in order to advance knowledge and understanding of sex differences with an emphasis on changes in the autonomic nervous system determined by heart rate variability. Abstract Heart rate variability (HRV) is commonly used in experimental studies to assess sympathetic and parasympathetic activities. The belief that HRV in rodents reflects similar cardiovascular regulations in humans is supported by evidence, and HRV in rats appears to be at least analogous to that in humans, although the degree of influence of the parasympathetic division of the autonomic nervous system (ANS) may be greater in rats than in humans. Experimental studies are based on control or baseline values, on the basis of which the change in ANS activity after a given experimental intervention is assessed, but it is known that the ANS in rats is very sensitive to various stress interventions, such as the manipulation itself, and ANS activity can also differ depending on sex, the time of measurement, and whether the animals are under general anaesthesia. Thus, for correct assessment, changes in ANS activity and their relationship to the observed parameter should be based on whether ANS activity does or does not change but also to what extent the activity is already changed at the start of the experiment. Since rats are considered to be the most suitable model animal for basic cardiovascular research, in this review we point out existing differences in individual HRV frequency parameters at the start of experiments (control, baseline values), taking into account sex in relation to time of measurement and anaesthesia.

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Section: Sex and Chronobiology Of Hrv Under General Anaesthesiamentioning

confidence: 99%

Sex differences, chronobiology and general anaesthesia in activities of the autonomic nervous system in rats

Švorc

Grešová

2023

Experimental Physiology

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“…These physiological responses through their influence on brain function are harmful, leading to deterioration of the quality of life; thus, MF exposure is an important biological indicator to be considered from the perspective of human body protection. Regarding the influence of low-intensity power frequency MFs on brain function, great interest has been gained and numerous findings have been obtained from various recent studies with human volunteers (Marino et al, 2004 ; Legros et al, 2012 , 2015 ), experimental animals (Manikonda et al, 2007 ; Szemerszky et al, 2010 ; Balassa et al, 2013 ; Rauš et al, 2013 , 2016 ; Salunke et al, 2014 ; Elmas and Comlekci, 2015 ), and cultured cells and tissues (Azanza et al, 2002 , 2013 ; Manikonda et al, 2007 ; Moghadam et al, 2008 , 2011 ; Varró et al, 2009 ; Moretti et al, 2013 ; Gramowski-Voß et al, 2015 ; Yang et al, 2015 ); however, the thresholds of neuronal modulation and implicated mechanisms by MF exposure are still under investigation. In addition, it has been recommended in the environmental health criteria (EHC) published by the World Health Organization (WHO) that the mechanism and threshold in the nervous system should be explained using cultured cells and theoretical models (World Health Organization, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Response of Cultured Neuronal Network Activity After High-Intensity Power Frequency Magnetic Field Exposure

et al. 2018

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High-intensity and low frequency (1–100 kHz) time-varying electromagnetic fields stimulate the human body through excitation of the nervous system. In power frequency range (50/60 Hz), a frequency-dependent threshold of the external electric field-induced neuronal modulation in cultured neuronal networks was used as one of the biological indicator in international guidelines; however, the threshold of the magnetic field-induced neuronal modulation has not been elucidated. In this study, we exposed rat brain-derived neuronal networks to a high-intensity power frequency magnetic field (hPF-MF), and evaluated the modulation of synchronized bursting activity using a multi-electrode array (MEA)-based extracellular recording technique. As a result of short-term hPF-MF exposure (50–400 mT root-mean-square (rms), 50 Hz, sinusoidal wave, 6 s), the synchronized bursting activity was increased in the 400 mT-exposed group. On the other hand, no change was observed in the 50–200 mT-exposed groups. In order to clarify the mechanisms of the 400 mT hPF-MF exposure-induced neuronal response, we evaluated it after blocking inhibitory synapses using bicuculline methiodide (BMI); subsequently, increase in bursting activity was observed with BMI application, and the response of 400 mT hPF-MF exposure disappeared. Therefore, it was suggested that the response of hPF-MF exposure was involved in the inhibitory input. Next, we screened the inhibitory pacemaker-like neuronal activity which showed autonomous 4–10 Hz firing with CNQX and D-AP5 application, and it was confirmed that the activity was reduced after 400 mT hPF-MF exposure. Comparison of these experimental results with estimated values of the induced electric field (E-field) in the culture medium revealed that the change in synchronized bursting activity occurred over 0.3 V/m, which was equivalent to the findings of a previous study that used the external electric fields. In addition, the results suggested that the potentiation of neuronal activity after 400 mT hPF-MF exposure was related to the depression of autonomous activity of pacemaker-like neurons. Our results indicated that the synchronized bursting activity was increased by hPF-MF exposure (E-field: >0.3 V/m), and the response was due to reduced inhibitory pacemaker-like neuronal activity.

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Investigation of effects of short‐term exposure to 50 HZ magnetic field on central, peripheral, and autonomic nervous systems in rats

Cited by 2 publications

References 36 publications

Sex differences, chronobiology and general anaesthesia in activities of the autonomic nervous system in rats

Sex differences, chronobiology and general anaesthesia in activities of the autonomic nervous system in rats

Response of Cultured Neuronal Network Activity After High-Intensity Power Frequency Magnetic Field Exposure

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