Investigation of Effects of Silymarin in 5-Fluorouracil Hepatotoxicity and Nephrotoxicity in Mice

Şengül, Emin; Gelen, Volkan; Yıldırım, Serkan; Gül, Esra Tuğçe; Dağ, Yusuf; Eser, Gizem; Gök, Melahat

doi:10.21203/rs.3.rs-448267/v1

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…Contributing to antioxidant defense systems in different ways, silymarin inhibits free radicals directly and the enzymes that cause these radicals to form [ 24 ]. In a study, when they looked at the therapeutic effects of silymarin and naringin against methotrexate-induced nephrotoxicity, silymarin was administered at 50 mg/kg for seven days.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Doğan

Meydan

Kömüroğlu

2022

International Journal of Clinical Practice

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Objective. This study aimed to investigate the effects of gallic acid and silymarin against nephrotoxicity and hepatotoxicity caused by cisplatin. Materials and Methods. In the study, 56 Wistar Albino rats were equally divided into eight groups. Group 1 was the control group; group 2 was the group receiving cisplatin; group 3 was the group receiving cisplatin + gallic acid; group 4 was the group receiving cisplatin + silymarin; group 5 was the group receiving cisplatin + silymarin + gallic acid; group 6 was the group receiving silymarin; group 7 was the group receiving gallic acid; group 8 was the group receiving gallic acid + silymarin. AST, ALT, urea, creatinine, albumin, globulin, and total protein levels were measured at the end of the study. Superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione (GSH), and 8-hydroxy-2′-deoxyguanosine (8OH-dG) levels were measured in kidney and liver tissues. Additionally, histopathological evaluations of the tissues were also performed. Results. In kidney and liver tissues, cisplatin significantly increased MDA and 8-OHdG levels compared with treatment groups ( p < 0.05 ). Silymarin-treated group significantly increased the SOD activity and GSH amount in the liver tissue compared with the cisplatin-treated group ( p < 0.05 ). Gallic acid significantly increased CAT activity compared with the cisplatin-treated group ( p < 0.05 ). It was determined that the cisplatin-treated group significantly decreased CAT and SOD activity compared with the control group ( p > 0.05 ). Gallic acid showed a significant increase in CAT and SOD activity in kidney tissue compared with the cisplatin-treated group ( p < 0.05 ). Conclusion. As a result, it was observed that gallic acid silymarin had a protective effect on cisplatin-induced nephrotoxic and hepatotoxic effects.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Doğan

Meydan

Kömüroğlu

2022

International Journal of Clinical Practice

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“…The liver is the major source of albumin synthesis. A decrease in serum albumin possibly suggests inflammation, chronic infections, kidney problems, and cirrhosis, among others [ 16 , 17 ]. The decreased albumin concentration in the patients suggests that some level of hepatocyte damage may occur following chemotherapy exposure.…”

Section: Discussionmentioning

confidence: 99%

“…The decreased albumin concentration in the patients suggests that some level of hepatocyte damage may occur following chemotherapy exposure. Normally, the lowering of albumin level indicates a liver disease [ 16 ]. This reduction could be attributed to changes in the free amino acid and protein metabolism and their synthesis in the liver.…”

Section: Discussionmentioning

confidence: 99%

Assessing the Hepatotoxic Effects of Fluoropyrimidine Chemotherapy in Male Iraqi Colorectal Cancer Patients

Challoob,

Mohammed

2024

Cureus

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Introduction: Colorectal cancer (CRC) is one the most frequently occurring cancer types among various populations. Fluoropyrimidine is the backbone of first-line chemotherapy, the oral capecitabine, or intravenous 5-fluorouracil (5-FU) in various combinations and schedules the chemotherapy regime in the treatment of a wide variety of gastrointestinal cancers. The enzyme dihydropyrimidine dehydrogenase (DPD) functions as the rate-limiting step in the metabolism of fluoropyrimidine chemotherapies, and patients with complete or partial DPD deficiency are at increased risk of severe and fatal toxicity during treatment with fluorouracil. Aim: This study aimed to examine the chemotoxicity of the 5-FU drug on hepatocytes in male Iraqi CRC patients. Materials and methods: This research is a cross-sectional study conducted between November 2022 and April 2023. The study included 80 male participants who had undergone surgical intervention for stage III CRC under the care of the Misan Health Directorate, Misan Center for Tumors Treatment, located in Misan, Iraq. Based on their subsequent surgical treatment, the participants were divided into two groups. The first group, comprising 45 males aged between 41 and 71 years, experienced a relapse despite receiving adjuvant therapy, which involved a singular cycle of fluoropyrimidine-based chemotherapy (5-FU). The second group consisted of 35 male patients with CRC, aged between 40 and 57 years, who did not experience a relapse post-adjuvant therapy. Their adjuvant therapy involved a single round of fluoropyrimidine-based chemotherapy with 5-FU. Relapse in patients was determined by assessing the white blood cell count (WBC). Results: Liver enzymes were significantly increased after 5-FU treatment, while the concentration of albumin was significantly decreased. Conclusion: The findings of our study clearly indicate that 5-FU induced hepatic injury, lowering the hepatocyte function with elevated levels of hepatic enzymes and low concentration of albumin in the blood, which is an important predictive marker of chemotherapy toxicity.

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“…SIL can play a protective role in 5-FLU induced oxidative stress in liver and kidney tissues by eliminates 5-FLU toxicity. The study concluded that this kind of effect is due to the powerful antioxidant and anti-inflammatory properties of SIL [49].…”

Section: Silymarin and Chemotherapeutic Drugsmentioning

confidence: 92%

Interaction of Bioactive Compounds With Ceramic Materials – A Review

PALTINEAN¹,

Tomoaia²,

RACZ³

et al. 2022

AnnalsARSciPhysChem

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This review examines the interaction between silymarin (SIL) and other plant-based bioactive compounds such as curcumin (CCM), piperine (PIP), resveratrol (RES), and icariin (ICA). Their combination revealed synergistic effects on colon (HCT116), breast (T47D) tumor cells, hepatocellular carcinoma, and periodontal disease. The review also addresses the interaction between these plant extracts with ceramic materials such as hydroxyapatite (HAP) and carotenoids with concrete examples of biomedical applications. Silymarin’s interaction with chemotherapeutic drugs (doxorubicin-DOX, paclitaxel-PCT and 5-Fluorouracil-5-FLU) and gold nanoparticles-GNPs and silver nanoparticles-SNPs is also debated. All these combinations can form composites of major importance in the biomedical field and to contribute significantly to orthopedic surgery where materials are needed for implants that face severe infections. This short review highlights the variety of multifunctional nanoparticles that open new opportunities in cancer treatment and the need to use the Langmuir Blodgett Technique that mimics the biological membrane and provides rich medical information.

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Investigation of Effects of Silymarin in 5-Fluorouracil Hepatotoxicity and Nephrotoxicity in Mice

Cited by 6 publications

References 24 publications

Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Assessing the Hepatotoxic Effects of Fluoropyrimidine Chemotherapy in Male Iraqi Colorectal Cancer Patients

Interaction of Bioactive Compounds With Ceramic Materials – A Review

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