Investigation of Efficacy of New Electrolyzed Water Generator for Oral Bacteria

Cho, In-Woo; Nam, Tae-Kye; Baek, Dong-Heon

doi:10.15236/ijcpd.2017.13.1.5

Cited by 6 publications

(8 citation statements)

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“…Anti‐biofilm efficacy from a mouthrinse perspective predominantly studied POU neutral‐pH EOW against various pathogens, including Aggregatibacter actinomycetemcomitans , Porphyromonas gingivalis , Streptococcus mutans, Streptococcus sobrinus, Staphylococcus aureus, Tannerella forsythia and C. albicans . One study targeted mixed‐species biofilms cultured from pooled saliva 78 . RTU EOW activity towards Helicobacter pylori biofilms was investigated in one report 79 .…”

Section: Resultsmentioning

confidence: 99%

“…Suspension and biofilm assays report efficacy as a reduction in colony forming units (cfu), non‐detectable counts, percentage killing and growth inhibition. Antibiofilm assays also report efficacy as changes to the biofilm cover (structural observations), 61,70,75,77,78,89,91,101,102,109–111 gene expression (RT‐qPCR) 79 and biofilm composition (16S rRNA gene sequencing) 92 . Significant microbicidal activity is reported in suspension assays either with fixed contact times or time‐kill assays against bacterial and fungal type strains, and clinical isolates 9,50,57,58,61–70,72–85,104,112 .…”

Section: Discussionmentioning

confidence: 99%

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Electrolysed oxidising water as a multi‐purpose biocide in dental healthcare—A scoping review

Krishnan,

Tompkins,

Lyons

et al. 2023

Gerodontology

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ObjectivesThe objective of this scoping review was to map evidence of electrolysed oxidising water (EOW) as a biocide for dental applications of relevance to older people and identify research gaps.BackgroundEOW is an emerging, “green,” and cost‐effective biocide. There are no reviews on the landscape of EOW research as either an antiseptic or disinfectant in dental healthcare or its suitability for the oral healthcare of older people.Materials and MethodsThe review follows the PRISMA Extension for Scoping Reviews (PRISMA‐ScR) guidelines. Database searches (Google Scholar, PubMed, Web of Science, Ovid, Scopus and Science Direct) were undertaken using MESH terms and Boolean operators with no date restrictions, to identify full‐text, original reports published in English‐language peer‐reviewed journals.ResultsThe search yielded 114 papers that met the inclusion/exclusion criteria. Dental applications of EOW include its use as an endodontic irrigant (39%); mouth rinse/surgical irrigant (21%); disinfectant for dental unit water lines (19%) and dental biomaterials (17%); and for antimicrobial efficacy, effects on oral tissues and on dental material properties. Most studies (83%) evaluated a single EOW formulation (acidic, moderately acidic or neutral) that was either generated at ‘point‐of‐use’ (POU; 72%), bottled (‘ready‐to‐use’, RTU; 24%) or from unspecified (3%) sources. Six reports evaluated storage‐related parameters and 25 evaluated clinical applications; 89 were in vitro studies and one investigated the cost‐effectiveness of POU EOW.ConclusionsNeutral‐pH, EOW is effective as an antimicrobial agent without deleterious effects on oral tissues. However, research on the impact of storage conditions, anti‐Candida biofilm efficacy and mechanism of action against yeasts, long‐term effects on denture materials and cost‐effectiveness is required to establish the suitability of EOW as a multipurpose biocide for dental healthcare, including infection‐control requirements relating to older people.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Electrolysed oxidising water as a multi‐purpose biocide in dental healthcare—A scoping review

Krishnan,

Tompkins,

Lyons

et al. 2023

Gerodontology

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“…ESS has become a new alternative for tissue asepsis in dentistry, surgery, dermatology, burns, and diabetic wounds [ 17 , 18 ]. Studies have described various ESS applications in dental surgery and the humidification, irrigation, and disinfection of acute and chronic wounds.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial efficacy of a pH-neutral electrolyzed super-oxidized solution for nonsurgical periodontal treatment

González-Cantú

Torres-Muñoz

Urrutia-Baca

et al. 2022

Heliyon

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“…Recently, novel oral antiseptics based on electrolyzed water (EW) with antimicrobial activity against oral pathogens have been developed [17][18][19][20]. EW is the product of the electrolysis of a diluted solution of NaCl in an electrolysis cell, inside which a diaphragm (partition or membrane) separates the anode and the cathode [21].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Anti-Biofilm Effect of an Electrolyzed Superoxidized Solution at Neutral-pH againstHelicobacter pylori

Lucio-sauceda

Urrutia-Baca

Gómez-Flores

et al. 2019

BioMed Research International

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The presence of Helicobacter pylori in the oral cavity has been associated to the failure of antimicrobial therapy in patients with gastrointestinal infection and the development of oral diseases. However, it has been reported that the maintenance of good oral hygiene can improve the therapeutic success rates, where the use of mouthwashes with anti-Helicobacter activity would help to achieve it. The aim was to evaluate the antimicrobial activity of OxOral® mouthwash against H. pylori and its effect on biofilm formation. The minimum inhibitory concentration (MIC) of OxOral® (pH = 6.4–7.5, ORP = 650–900 mV) against H. pylori was calculated testing serial dilutions 0.117–15 ppm against 1 × 108 CFU/mL of H. pylori (ATCC® 700824™) by broth microdilution method using 96‐well plates. The H. pylori biofilm formation was determined by the optical density measurement at 600 nm from coverslips stained with 0.1% crystal violet. The gene expression of ureA, luxS, flaA, omp18, and lpxD were analyzed by RT‐qPCR. OxOral® cytotoxicity was evaluated in a human gingival fibroblast cell line by MTT assay. MIC was of 3.75 ppm, with 99.7 ± 7.7% bacterial growth inhibition. In the negative control, the biofilm formation was observed, whereas when bacteria were treated with OxOral® at 0.234, 0.469, and 0.938 ppm, an inhibition of 35.5 ± 0.9%, 89.1 ± 1.2%, and 99.9 ± 5.5% were obtained, respectively. The gene expression analysis showed that flaA, omp18, and lpxD genes were down‐regulated with OxOral® compared with control (p<0.05). Low cytotoxicity of 16.5 ± 7.6% was observed at the highest dose (15 ppm); no significant differences were observed from 15 to 0.469 ppm compared to the control of untreated cells (p>0.05). Our results reveal an important anti-Helicobacter activity of OxOral® and open the possibility of its therapeutic use new studies, which would increase the success rate of conventional therapies against H. pylori.

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Investigation of Efficacy of New Electrolyzed Water Generator for Oral Bacteria

Cited by 6 publications

References 0 publications

Electrolysed oxidising water as a multi‐purpose biocide in dental healthcare—A scoping review

Electrolysed oxidising water as a multi‐purpose biocide in dental healthcare—A scoping review

Antibacterial efficacy of a pH-neutral electrolyzed super-oxidized solution for nonsurgical periodontal treatment

Antimicrobial and Anti-Biofilm Effect of an Electrolyzed Superoxidized Solution at Neutral-pH againstHelicobacter pylori

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