Carbon dioxide fl ooding is an effective means of enhanced oil recovery for low permeability reservoirs. If fractures are present in the reservoir, CO 2 may flow along the fractures, resulting in low gas displacement effi ciency. Reservoir pore pressure will fl uctuate to some extent during a CO 2 fl ood, causing a change in effective confining pressure. The result is rock deformation and a reduction in permeability with the reduction in fracture permeability, causing increased fl ow resistance in the fracture space. Simultaneously, gas cross fl owing along the fractures is partially restrained. In this work, the effect of stress changes on permeability was studied through a series of fl ow experiments. The change in the fl owrate distribution in a matrix block and contained fracture with an increase in effective pressure were analyzed. The results lead to an implicit comparison which shows that permeability of fractured core decreases sharply with an increase in effective confi ning pressure. The fracture fl owrate ratio declines and the matrix fl owrate ratio increases. Fracture fl ow will partially divert to the matrix block with the increase in effective confi ning pressure, improving gas displacement effi ciency.