Investigation of Elevated Ketone Bodies in Low Carbohydrate Diet (LCD)

Bando, Hiroshi; Ebe, Koji; Muneta, Tetsuo; Bando, Masahiro; Yasuda, Yoshikazu

doi:10.4172/2165-8048.1000260

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…In the diabetic patients provided with LCD meal, blood values of total ketone bodies showed 160 to 4,000 μmol/L (0.16 to 4 mmol/L) [25]. From this data, current total KB and 3-OHBA would be in the range as expected.…”

Section: Discussionsupporting

confidence: 70%

Normalized glucose variability by Low Carbohydrate Diet (LCD) in CGM study

Muneta¹,

Kawaguchi²,

Hayashi³

et al. 2019

Asp Biomed Clin Case Rep

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In diabetic practice, continuous glucose monitoring (CGM) has been more used for glucose variability. Authors have reported and developed the clinical study of Low Carbohydrate Diet (LCD) and Calorie Restriction (CR) through Japan LCD Promotion Association (JLCDPA). A diabetic case is presented with normalizing glucose variability by LCD meal checked by CGM. Case is 51 years female with type 2 diabetes mellitus (T2DM). At first visit, HbA1c was 10.0%, glucose was 288mg/dL, BMI 39.1, GOT 16IU/mL, HDL-C 33mg/dL, Triglyceride 152mg/dL. CR meal was provided on day-1 to day-5 and LCD meal with 12% carbohydrate on day-6 to day-13. Average glucose value from CGM was 292mg/dL, 235mg/dL, 160mg/dL, 140mg/dL, 124mg/dL in day 3,5,7,9,11 respectively. On day-13, total Ketone bodies (T-KB) 540μmol/L (-131), Acetoacetic acid (AcAc) 86μmol/L (-55) and 3-hydroxybutyric acid (3-OHBA) 454μmol/L (-85). Weight reduction was 5kg on day-14 and 11.2kg on day-70 with BMI 34.6. Thus, LCD showed a remarkable glucose-lowering effect in short term. FreeStyle Libre (Abbott, USA) seems to be a useful apparatus for monitoring the detailed fluctuation of blood glucose. These results would become fundamental and reference data and contribute to the LCD research development in the future.

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Section: Discussionsupporting

confidence: 70%

Normalized glucose variability by Low Carbohydrate Diet (LCD) in CGM study

Muneta¹,

Kawaguchi²,

Hayashi³

et al. 2019

Asp Biomed Clin Case Rep

Self Cite

View full text Add to dashboard Cite

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Urinary C-Peptide Excretion for Diabetic Treatment in Low Carbohydrate Diet (LCD)

Bando

Ebe²,

Muneta³

et al. 2018

JOD

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Background: Arguments have continued about Low Carbohydrate Diet (LCD) and Calorie Restriction (CR). Authors have reported clinical research of LCD and Morbus (M) value. Subjects and Methods: Subjects enrolled are 84 patients with Type 2 diabetes mellitus (T2DM), 60.9 ± 10.9 years. The protocol were as follows: 1) CR diet on day 1, 2 with 60% carbohydrates, and LCD on day 3-14 with 12% carbohydrates, 2) Daily profile of blood glucose 7 times a day on day 2 (CR) and day 4 (LCD), 3) urinary C-Peptide radioimmunoassay (u-CPR) excretion, 4) M value calculation, 5) investigation of these data with correlation. Results: Subjects were classified into 4 groups according to M value, which were .4–21, 23–66, 29–192, 200–728, respectively. HbA1c value was 6.2, 8.0, 7.8, 9.2 %, respectively. Blood glucose in median from day 2 to day 4 were 123 to 107 mg/dL, 164 to 130 mg/dL, 193 to 156 mg/dL, 277 to 201 mg/dL, respectively. M value in median from day 2 to 4 was 6.3 to 9, 41 to 7, 108 to 16, 367 to 88, respectively. u-CPR was 88 to 58, 53 to 35, 65 to 52, 74 to 64, respectively. There were significant correlations among among glucose, M value and u-CPR. Discussion and Conclusion: Average glucose, M value and u-CPR decreased remarkably on day 4. As average glucose and M value were higher, decrease degree were larger. These results suggested that carbohydrate in meal would influence glucose variability in T2DM. Our data would become basic data for pathophysiological analysis of glucose variability research in the future.

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Ketogenic Diet is Beneficial from Hyperketonemia by Low Carbohydrate Diet (LCD)

Bando¹

2019

EJBMR

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Investigation of Elevated Ketone Bodies in Low Carbohydrate Diet (LCD)

Cited by 3 publications

References 24 publications

Normalized glucose variability by Low Carbohydrate Diet (LCD) in CGM study

Normalized glucose variability by Low Carbohydrate Diet (LCD) in CGM study

Urinary C-Peptide Excretion for Diabetic Treatment in Low Carbohydrate Diet (LCD)

Ketogenic Diet is Beneficial from Hyperketonemia by Low Carbohydrate Diet (LCD)

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