Investigation of Ethyl Cellulose Microsponge Gel for Topical Delivery of Eberconazole Nitrate for Fungal Therapy

Bothiraja, C.; Gholap, Amol D.; Shaikh, Karimunnisa S.; Pawar, Atmaram

doi:10.4155/tde.14.43

Cited by 52 publications

(39 citation statements)

References 29 publications

(31 reference statements)

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“…They are used Page 4 of 24 as a carrier system since have capacity to entrap wide range of actives in their non-collapsible structures with porous surface; through which active ingredients are released in controlled manner [8]. Further these microsponges with actives can be incorporated into formulations such as tablets, capsules, creams, gel, lotions and powders and share a broad package of benefits [9][10][11][12][13][14]. The fundamental appeal of the microsponge technology stems from the intricacy experienced with conventional formulations in releasing active ingredients over an extended period of time.…”

Section: Introductionmentioning

confidence: 99%

Microsponge based drug delivery system for augmented gastroparesis therapy: Formulation development and evaluation

Osmani

Aloorkar²,

Thaware³

et al. 2015

Asian Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Microsponge based drug delivery system for augmented gastroparesis therapy: Formulation development and evaluation

Osmani

Aloorkar²,

Thaware³

et al. 2015

Asian Journal of Pharmaceutical Sciences

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“…Microsponges have interconnecting pores within a non-collapsible sponge like spherical structure and have the ability to encapsulate a large variety of hydrophilic and hydrophobic compounds as well as macromolecules (Roh et al, 2016;Vikrant and Jessy, 2007;Zhang et al, 2016). Microsponges are widely studied in topical preparations because of their larger size, which usually ranges between 5 to 300 micron (Bothiraja et al, 2014). The larger size of these porous microspheres allows for retention at the skin surface, thus aids in delivery of various drugs for topical ailments (Li et al, 2013;Pandit et al, 2016;Patel et al, 2016;Rizkalla et al, 2011;V.…”

Section: Introductionmentioning

confidence: 99%

Influence of polymer ratio and surfactants on controlled drug release from cellulosic microsponges

Shahzad

Saeed

Ghori

et al. 2018

International Journal of Biological Macromolecules

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Microsponge refers to a highly cross-linked particle system with a capacity to adsorb (like a dry sponge) pharmaceutical materials. There are various methods available to prepare microsponge formulations, in this study we used quasi emulsion-solvent diffusion method with a combination of hydrophobic (ethyl cellulose) and hydrophilic (hydroxypropyl methylcellulose) polymers mediated via Tween 80 and polyvinyl alcohol. Various ratios and amounts of the polymers and surfactants were used to prepare microsponge formulations using ketoprofen as a model drug and extensively characterised. Our results, for the first time, indicate successful and optimised formulation with desired pharmaceutical characteristics using a combination of hydrophobic and hydrophilic polymers.

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“…[ 5 6 ] To conquer the renowned adverse effects, use of novel drug delivery systems has been proposed due to the potential of such systems to diminish such occurrences without affecting the efficacy. [ 7 8 ]…”

Section: Introductionmentioning

confidence: 99%

Fabrication, characterization, and evaluation of microsponge delivery system for facilitated fungal therapy

Moin

Deb

Osmani

et al. 2016

J Basic Clin Pharma

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Objective:The rationale behind present research vocation was to develop and investigate a novel microsponge based gel as a topical carrier for the prolonged release and cutaneous drug deposition of fluconazole (FLZ); destined for facilitated fungal therapy.Materials and Methods:Microsponges were prepared using quasi-emulsion solvent diffusion method using Eudragit S-100. In the direction of optimization, the effect of formulation variables (drug-polymer ratio and amount of emulsifier) and diverse factors affecting physical characteristics of microsponge were investigated as well. Fabricated microsponges were characterized by differential scanning calorimetry, Fourier transform-infrared, scanning electron microscopy (SEM), particle size analysis, and also evaluated for drug content, encapsulation efficiency, in vitro drug release and in vitro antifungal activity.Results:Compatibility studies results reflected no sign of any chemical interaction between the drug and polymers used. Whereas, varied drug-polymer ratios and emulsifier concentration indicated significant effect on production yield, drug content, encapsulation efficiency, particle size and drug release. Spherical microsponges with a porous surface and 29.327 ± 0.31 μm mean particle size were evident from SEM micrographs. In vitro release outcomes, from microsponge loaded gels depicted that F1 formulation was more efficient to give extended drug release of 85.38% at the end of 8 h, while conventional formulation by releasing 83.17% of drug got exhausted incredibly earlier at the end of 4 h merely. Moreover, microsponge gels demonstrated substantial spreadability and extrudability along with promising antifungal activity.Conclusions:Fabricated microsponges would be impending pharmaceutical topical carriers of FLZ and a leading alternative to conventional therapy for efficient, safe and facilitated eradication of fungal infections.

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Investigation of Ethyl Cellulose Microsponge Gel for Topical Delivery of Eberconazole Nitrate for Fungal Therapy

Abstract: Developed ethyl cellulose microsponges could be potential pharmaceutical topical carriers of EB in antifungal therapy.

Cited by 52 publications

References 29 publications

Microsponge based drug delivery system for augmented gastroparesis therapy: Formulation development and evaluation

Microsponge based drug delivery system for augmented gastroparesis therapy: Formulation development and evaluation

Influence of polymer ratio and surfactants on controlled drug release from cellulosic microsponges

Fabrication, characterization, and evaluation of microsponge delivery system for facilitated fungal therapy

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