Investigation of extracts from (Tunisian) Cyperus rotundus as antimutagens and radical scavengers

Kilani, Soumaya; Ammar, Rebaï Ben; Bouhlel, Inès; Abdelwahed, A.; Hayder, Nawel; Mahmoud, Amor; Ghédira, Kamel; Chekir‐Ghedira, Leila

doi:10.1016/j.etap.2005.05.012

Cited by 85 publications

(35 citation statements)

References 26 publications

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“…In this current study, we demonstrated that DNA does not seem to be a relevant target for E. japonica-tested extracts and they do not produce DNA lesions which should block DNA synthesis and lead to the induction of the SOS system. These results were in agreement with our previous studies (Ben Boubaker et al, 2010;Kilani et al, 2005). In the present experimental conditions, the aqueous and TOF extracts were depicted as effective antimutagens against direct and indirect acting toxicants, suggesting that these extracts can act through various mechanisms.…”

Section: Discussionsupporting

confidence: 82%

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

Mokdad-Bzéouich

Kilani-Jaziri

Mustapha

et al. 2015

Pharmaceutical Biology

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Context: The leaves of Eriobotrya japonica (Thunb.) Lindl. (Rosaceae) are used in traditional medicine to treat inflammatory diseases. However, information about the antigenotoxic and antioxidant properties of its leaves remains to be elucidated. Objective: The objective of this work was to evaluate the mutagenic/antimutagenic, genotoxic/ antigenotoxic, and antioxidant potentials of aqueous and total oligomers flavonoid (TOF) extracts from E. japonica. Materials and methods: The mutagenic/antimutagenic and genotoxic/antigenotoxic potentials of extracts (50, 250, and 500 mg/plate) were evaluated, respectively, by the Ames test with 48 h incubation and the SOS chromotest test with 2 h incubation. The antioxidant capacity of these extracts (ranging from 50 to 700 mg/mL) was tested using xanthine/xanthine oxidase and the deoxyribose assays. Results: Eriobotrya japonica extracts showed neither mutagenic nor genotoxic effect. The highest protective effect against methyl methanesulfonate and 2-aminoanthracene was obtained in the presence of aqueous extract, with IC 50 values of 80 and 140 mg/plate, respectively, against S. typhimurium TA104. Moreover, this extract (500 mg/plate) was also able to reduce significantly the genotoxicity induced by nitrofurantoin and aflatoxin B1 with IC 50 values of 140 and 240 mg/assay, respectively. Likewise, aqueous and TOF extracts inhibited xanthine oxidase and superoxide anion formation with IC 50 values ranging from 45 to 95 and from 70 to 90 mg/mL, respectively. However, TOF extract is more efficient in inhibiting hydroxyl radical and chelating iron ion with IC 50 values of 140 and 400 mg/mL, respectively, when compared with the aqueous extract. Conclusion: Eriobotrya japonica prevents the genotoxicity of some carcinogenic substances probably thanks to its antioxidant capacities.

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Section: Discussionsupporting

confidence: 82%

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

Mokdad-Bzéouich

Kilani-Jaziri

Mustapha

et al. 2015

Pharmaceutical Biology

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“…[17][18][19] Previous studies have demonstrated that Cyperus rotundus has extensive pharmacological properties, including antibacterial, 18) and antimutagenic. 20) Moreover, a recent study showed that the essential oil of Cyperus rotundus exhibits considerable antigenotoxic, antimutagenic, and antibacterial effects as well. 21) It has been reported that α-cyperone, a sesquiterpene compound represents 25.23% of the total oil and is the most abundant compound in Cyperus rotundus oil.…”

Section: )mentioning

confidence: 99%

α-Cyperone Inhibits PMA-Induced EPCR Shedding through PKC Pathway

Zhao

Zhang

et al. 2017

Biological & Pharmaceutical Bulletin

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α-Cyperone, a sesquiterpene compound represents 25.23% of the total oil and is the most abundant compound in Cyperus rotundus oil. Endothelial cell protein C receptor (EPCR) is a main member in protein C (PC) anti-coagulation system. EPCR could be shed from cell surface, and is mediated by tumor necrosis factor-α converting enzyme (TACE). Nothing that EPCR is a marker of vascular barrier integrity in vascular inflammatory disease and takes part in systemic inflammatory disease. In this study, we investigated whether α-cyperone could inhibit EPCR shedding. To observe the effect, we investigated this issue by detection the effect of α-cyperone on phorbol-12-myristate 13-acetate (

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“…Anti-mutagens and radical scavengers (Kilani et al 2005), Antimalarial (Thebtaranonth et al 1995), Antidiarrheal (Uddin et al 2006b), Antibacterial activity (Nima et al 2008), Antioxidant activity (Nagulendran et al 2007), wound healing activity (Puratchikody et al 2006) 13 Physalis minima Urinary tract infection Earache, stomach pain, pain (Islam et al 2014), urinary track, diuretic, joint inflammation, blood purifier, skin disease, pimples, liver tonic (Parul and Vashistha 2015) Analgesic activity (Anand et al 2014), Diuretic activity Antiulcer Activity (Tammu et al 2013), CNS depressant activity (Dharamveer et al 2009), Antibacterial Potential , Antioxidant Activity (Gupta et al 2010), Antifertility (Sudhakaran et al 1999) (Devi et al 2012) 15 Cynodon dactylon Menstruation, milk yield enhancer Scanty, irregular periods (Yadav et al 2006), piles, irritation of urinary tract, vomiting, wounds (Khan et al 2013b) Antioxidant activity (Sies 1997), Anticancer activity (AlbertBaskar and Ignacimuthu 2010), Anticonvulsant activity (Pal 2009), Hypoglycemic activity , Immunomodulatory activity (Mangathayaru et al 2009), Hepatoprotective activity (Surendra et al...…”

Section: Syzygium Cuminimentioning

confidence: 99%

Connecting corporations and communities: Towards a theory of social inclusive open innovation

Gupta¹,

Dey

Singh

2017

Journal of Open Innovation: Technology, Market, and Complexity

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Despite pervasiveness of the market forces and supplementary role of the state and in some cases, even civil society organisations, there are unmet social needs which remain unaddressed by the existing institutions. With industrial growth becoming jobless, the need for new models of social innovation is being felt all around the world to provide jobs to the youth, skills for the new economy and entrepreneurial opportunities for transforming resources and skills. The persistence of some of these unmet needs (also referred as wicked problems sometimes) or unaddressed problems for a long time shows that the existing institutional arrangements are inadequate for the purpose. Innovations are imperative. A socio-ecological system that recognizes and rewards innovation can withstand many external shocks, provided it is agile and innovates quickly to remain responsive to emergent challenges (Anderies, Janssen, & Ostrom. Ecology and society, 9 (1)

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Investigation of extracts from (Tunisian) Cyperus rotundus as antimutagens and radical scavengers

Cited by 85 publications

References 26 publications

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

Evaluation of the antimutagenic, antigenotoxic, and antioxidant activities ofEriobotrya japonicaleaves

α-Cyperone Inhibits PMA-Induced EPCR Shedding through PKC Pathway

Connecting corporations and communities: Towards a theory of social inclusive open innovation

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