Investigation of factors affecting ashesion of 99Tcm labelled colloids to glass vials

At, Elliott; Murray, Thomas M.; Te, Hilditch; Tl, Whateley

doi:10.1097/00006231-199005000-00005

Cited by 9 publications

(6 citation statements)

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“…Some groups have already reported the adsorption of various radiopharmaceuticals onto glass vials and single-use plastic syringes. Adhesion of various colloids on glass vials was investigated by Elliott et al (1) and Porter et al (2). The adsorption behavior of some radiopharmaceuticals on glass vials has been studied (3,4).…”

mentioning

confidence: 99%

Adsorption of 99mTc-Radiopharmaceuticals onto Injection Vials and Syringes

Ahmad¹,

Rehman²,

Mansur³

et al. 2008

Journal of Nuclear Medicine Technology

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Many groups have reported the adsorption or retention of 99m Tcradiopharmaceuticals on injection vials and disposable plastic syringes. Such an enormously high loss of radioactivity would result in poor images, radiation exposure, waste, and economic burdens. We therefore decided to investigate the extent of adsorption or retention of several 99m Tc-radiopharmaceuticals on injection vials, rubber stoppers, and plastic syringes. These radiopharmaceuticals are produced as lyophilized kits in our department and supplied to various hospitals practicing nuclear medicine in Pakistan. Methods: A vial containing lyophilized material was reconstituted with 3 mL of freshly eluted Na 99m TcO 4 . A 1-mL aliquot of the resulting solution was withdrawn into a syringe at 0.25, 0.5, 1, 3, and 5 h after preparation. All preparations were stored at room temperature (;22°C). After each withdrawal, the vial was reweighed and the activity remaining in the vial was measured using a radioisotope calibrator. The sample was reinjected into the vial. From the original weight and activity of solution in the vial, the initial activity per gram was calculated. From the weight and activity remaining in the vial after withdrawal of the sample, the activity per gram of the sample was calculated. From the difference between the initial activity per gram and the activity per gram of the sample, the percentage of 99m Tc adsorbed on the vial was calculated. All preparations were kept in the syringe for 15 min, and the activity was measured before and after the syringe was emptied. The needle and plunger of the syringe were separated, and activity in the needle and plunger was also measured. Results: The labeling efficiency of all radiopharmaceuticals used during these studies was more than 95%. In most cases, the activity of 99m Tc found on the rubber stopper was less than 1%. Adsorption of 99m Tc onto vials increased gradually with storage time. Adsorption was minimal at the initial stages, whereas maximum retention was noted after 5 h. Nearly 5% adsorption of activity was observed after 5 h of storage time on vials of sestamibi, mercaptoacetyltriglycine, dextran, ciprofloxacin, and dimercaptosuccinic acid (III and V). Retention of activity on needles ranged from 1% to 2% for all preparations studied. Plungers did not show any significant retention of radioactivity; in most cases, retention was less than 0.5%. The maximum retention of radioactivity on plastic syringe bodies was more than 3% for sestamibi, dimercaptosuccinic acid, dextran, pyrophosphate, and phytate. Conclusion: The results revealed that losses of radioactivity from 99m Tc-radiopharmaceuticals in these objects (glass vial, rubber stopper, plastic syringes, plungers, and needles) are not alarming in our setup.

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mentioning

confidence: 99%

Adsorption of 99mTc-Radiopharmaceuticals onto Injection Vials and Syringes

Ahmad¹,

Rehman²,

Mansur³

et al. 2008

Journal of Nuclear Medicine Technology

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“…Adsorption onto vials and syringes [1][2][3][4][5][6][7] and reductions in radiochemical purity caused by containers [8,9] are recognized problems. Agitation is also known to affect the particle size of a particular radiocolloid [12].…”

Section: Discussionmentioning

confidence: 99%

“…Supplying 99m Tc-Nanocoll in a syringe should minimize (1) the handling of radioactive material in the theatre, (2) the exposure of theatre staff to radiation, (3) the potential for radioactive contamination, and (4) the disposal of radioactive waste. There are many reports of the quality of 99m Tc radiopharmaceuticals being compromised by their containers [1][2][3][4][5][6][7][8][9]. One of the aims of this work was therefore to determine if a capped syringe is a satisfactory container in which to supply 99m Tc-Nanocoll.…”

Section: Introductionmentioning

confidence: 99%

Preparation of 99mTc-Nanocoll for use in sentinel node localization: Validation of a protocol for supplying in unit-dose syringes

O’Brien

Duffin

Millar

2006

Nuclear Medicine Communications

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“…Primary particles of 99m Tc-tin colloid were reported as having a $0.4 mm diameter, 5 or a mean particle size of 234 AE 22 nm at reconstitution that increases to 2.3 AE 0.8 mm with agitation 4 h later. 13 For 99m Tc-tin fluoride colloid, the primary colloidal particles exist in the filtrate after the 0.2 mm filtration step, and prior to 99m Tc-pertechnetate reconstitution. This is supported with evidence from the PSD data derived from non-radioactive membrane filtration experiments, and mass spectrometry that identified higher order Sn ions.…”

Section: Radiocolloid Formationmentioning

confidence: 99%

“…The electrostatic surface charge is the electrical double layer, and this inherent property governs the stability and binding characteristics of a colloid. Tin fluoride colloid particularly, binds by surface adhesion to glass 13 or to different cell types in whole blood 7 such that the particle structure is conserved. It was previously reported that Na + increases the aggregation rate of tin fluoride colloid prepared after 0.2 mm filtration.…”

Section: Radiocolloid Formationmentioning

confidence: 99%

Physico-chemical characterisation of99mTc-tin fluoride colloid agent used for labelling white cells

Tsopelas

2006

J Label Compd Radiopharm

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Tc-tin fluoride colloid is an agent used to label leucocytes, for the imaging and diagnosis of inflammatory conditions including Crohn's disease. Despite previous investigations, this radiolabelling agent is still poorly characterised. The aim of this work was to examine the process of formation and stability of 99m Tc-tin fluoride colloid using mass spectrometry, membrane filtration and atomic absorption spectrophotometric techniques. Tin-oxide bonds in tin clusters were identified in the stannous fluoride reagent vial by mass spectrometry. From radioactive particle size distribution experiments, the facile disruption of radiocolloid particles with excess oxygen gas contrasted to the partial hydrolysis of Sn(II) during the formation process. Under the standard conditions, 10% of particles were determined as 1-3 mm, and this population coordinated 96% of the 99m Tc added. Colloid particle formation and the reduction of 99m Tc-pertechnetate is discussed. Sodium fluoride may optimise 1-3 mm radioactive particle size, by regulating particle growth. Tc-tin fluoride colloid is affected by positive or negative charge, as either Al, Mo ions or solid membranes, resulting in either coagulation and/or deflocculation of the particles.

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Investigation of factors affecting ashesion of 99Tcm labelled colloids to glass vials

Cited by 9 publications

References 0 publications

Adsorption of 99mTc-Radiopharmaceuticals onto Injection Vials and Syringes

Adsorption of 99mTc-Radiopharmaceuticals onto Injection Vials and Syringes

Preparation of 99mTc-Nanocoll for use in sentinel node localization: Validation of a protocol for supplying in unit-dose syringes

Physico-chemical characterisation of99mTc-tin fluoride colloid agent used for labelling white cells

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