Investigation of Fusidic Acid Resistance Determinants in Methicillin-Resistant Staphylococcus aureus obtained in Kuwait Hospitals

Udo, Edet E.; Boloki, H.; Musaileem, W. Al; Verghese, T.

doi:10.1016/j.jiph.2020.01.051

Cited by 2 publications

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“…1 which also includes the reasons for rejection). In the next step, upon full text research, 208, 143, 71 articles were included for FRSA, FRMRSA, and FRMSSA, respectively [ 11 , 20 – 233 ]. The characteristics of the included articles are shown in Additional file 1 : Tables S1, S2, and S3.…”

Section: Resultsmentioning

confidence: 99%

The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis

Hajikhani

Goudarzi

Kakavandi

et al. 2021

Antimicrob Resist Infect Control

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Background and aim Staphylococcus aureus (S. aureus) is one of the most common pathogens causing nosocomial and community-acquired infections with high morbidity and mortality rates. Fusidic acid has been increasingly used for the treatment of infections due to methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The present study aimed to determine the precise prevalence of fusidic acid resistant MRSA (FRMRSA), fusidic acid resistant MSSA (FRMSSA), and total fusidic acid resistant S. aureus (FRSA) on a global scale. Methods Several international databases including Medline, Embase, and the Web of Sciences were searched (2000–2020) to discern studies addressing the prevalence of FRSA, FRMRSA, and FRMSSA. STATA (version14) software was used to interpret the data. Results Of the 1446 records identified from the databases, 215 studies fulfilled the eligibility criteria for the detection of FRSA (208 studies), FRMRSA (143 studies), and FRMSSA (71 studies). The analyses manifested that the global prevalence of FRSA, FRMRSA, and FRMSSA was 0.5%, 2.6% and 6.7%, respectively. Conclusion This meta-analysis describes an increasing incidence of FRSA, FRMSSA, and FRMRSA. These results indicate the need for prudent prescription of fusidic acid to stop or diminish the incidence of fusidic acid resistance as well as the development of strategies for monitoring the efficacy of fusidic acid use.

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Section: Resultsmentioning

confidence: 99%

The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis

Hajikhani

Goudarzi

Kakavandi

et al. 2021

Antimicrob Resist Infect Control

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“…For the indirect activity, the investigated products were combined at a sub-MIC concentration with penicillin V and fusidic acid. Those β -lactam and steroidal antibiotics are commonly used to treat either systemic or topical MRSA infections, respectively, although MRSA are usually more resistant to both of them [ 1 , 20 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones

et al. 2021

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The increasing bacterial resistance to antibiotics is a worldwide concern. Essential oils are known to possess remarkable antibacterial properties, but their high chemical variability complicates their development into new antibacterial agents. Therefore, the main purpose of this study was to standardize their chemical composition. Several commercial essential oils of ajowan (Trachyspermum ammi L.) and thyme (chemotype thymol) (Thymus vulgaris L.) were bought on the market. GC–MS analysis revealed that thyme essential oils have a chemical composition far more consistent than ajowan essential oils. Sometimes thymol was not even the major compound. The most abundant compounds and the homemade mixtures were tested against two Staphylococcus aureus strains. The antibacterial property of β-caryophyllene presented no direct activity against S. aureus LMG 15975, but in association with thymol or carvacrol at equal percentages an MIC of 125 μg/mL was observed. The mixture of those three compounds at equivalent percentages also decreased by 16-fold the MIC of the penicillin V. Against S. aureus LMG 21674, β-caryophyllene presented an MIC of 31.3 μg/mL and decreased by 267-fold the MIC of the penicillin V. These observations led us to question the benefits of using a complex chemical mixture instead of one active compound to fight bacterial resistance.

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Investigation of Fusidic Acid Resistance Determinants in Methicillin-Resistant Staphylococcus aureus obtained in Kuwait Hospitals

Cited by 2 publications

References 0 publications

The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis

The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis

Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones

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