Investigation of FXID and BLAD Diseases in Holstein Crossbreed Cattles Reared in Turkey

Aksel, Esma Gamze; Daldaban, Fadime; Arslan, Korhan; Keçeli, Hasan Hüseyin; Akyüz, Bilal

doi:10.32707/ercivet.878012

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…Similarly, Meydan et al, (2010) investigated the BLAD, DUMPS, CVM, Bovine Citrulinaemia (BC), and FXID diseases in 350 HF cattle reared in different regions of Türkiye in which a total of 14 and 12 animals were reported to be carriers of CVM and FXID disorders, respectively. On the contrary, no CVM carriers were reported in 150 heads of HF population raised in Kayseri province of Türkiye (Kulaklı andAkyüz 2011). Karsli et al, (2011) reported a low prevalence of FXID (0.4%), while no DUMPS carriers were present in a total of 504 animals belonging to HF breed reared in different districts of Antalya province of Türkiye.…”

Section: Resultsmentioning

confidence: 98%

Investigation of Some Autosomal Recessive Inherited Diseases (BLAD, DUMPS, CVM, and FXID) in Holstein Cattle

TÜRKMEN,

DEMİR,

BİLGİNER

et al. 2023

Livestock Studies

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Genetic disorders are often transmitted via autosomal recessive inheritance, which negatively affect health, welfare, and yield traits in farm animals such as cattle. In this study, a total of 80 animals belonging to Holstein Friesian (HF) reared in the dairy farm of Akdeniz University were investigated in terms of Bovine Leukocyte Adhesion Deficieny (BLAD), Deficiency of Uridine Monophosphate Synthase (DUMPS), Factor XI Deficiency (FXID), and Complex Vertebral Malformation (CVM) via three molecular genotyping methods such as Polymerase Chain Reaction (PCR), PCR-Restriction Fragment Length Polymorphism (PCR-RFLP), and Allele-Sprcific PCR (AS-PCR). BLAD and DUMPS were analysed by PCR-RFLP, while PCR and AS-PCR were utilized to investigate FXID and CVM disorders, respectively. Based on fragment patterns on agarose gel electrophoresis, animals were genotyped as normal, mutant, and carrier. In this study, no carrier or mutant animals were detected for BLAD, CVM, DUMPS, and FXID diseases in HF cattle, since these animals were previously imported from disease-free dairy farms located in different provinces of Türkiye. Nevertheless, this population should be periodically checked for autosomal genetic disorders, since inherited diseases may be observed in the next generations due to causative mutations in the related genomic regions.

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Section: Resultsmentioning

confidence: 98%