Investigation of haptoglobin, serum amyloid A, and some biochemical parameters in calves with omphalitis

Abstract

Aim:In this study, it was aimed to determine the concentration of some important acute phase proteins (APPs) and some biochemical parameters pre-operative and post-operative in calves with omphalitis.Materials and Methods:A total of 20 calves were used in the study and they consist of 10 clinically healthy calves that were used as a control and 10 calves with omphalitis were used as the treatment group. Blood samples were collected from Vena jugularis of animals to tubes with anticoagulant (sodium citrate) and without anticoagulants, pre-operative (day 0), and post-operative (day 7). Samples were used to determine the concentration of haptoglobin (Hp), serum amyloid A (SAA), ceruloplasmin (Cp), fibrinogen, glucose, total protein, albumin, urea, total bilirubin, creatinine, calcium, phosphorus, aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) concentrations.Results:While the Hp, SAA, Cp, fibrinogen, urea, creatinine, total bilirubin, ALP, and GGT concentrations were statistically and significantly increasing rather than the control group during the pre-operative period for calves with omphalitis, they decreased to the post-operative period. Moreover, an insignificant increase in the glucose, total protein, and AST concentrations and an insignificant decrease in the albumin, calcium, and phosphorus concentrations were statistically determined.Conclusion:We have the opinion that the assessment of biochemical parameters and especially APP levels in calves with the omphalitis together with the clinical findings may be important in terms of the treatment and prognosis.

Correlation of serum acute-phase proteins with bone repair in rabbits (Oryctolagus cuniculus) submitted to partial radio ostectomy

“…TOTHOVA et al 2016) reported a drop in albumin in abdominal procedures in humans in the immediate postoperative period. Therefore, we believed that our results showed that there were no significant inflammatory complications to alter the concentrations of albumin, in agreement with MYLONAKIS et al (2012), BOZUKLUHAN et al (2018), andTOTHOVA et al (2019b).…”

“…At M15d and M21d, the values were smaller and statistically different from M0 (P≤0.05) (Table 1). Following the same response pattern discussed earlier, there is an increase in this PFA in more severe inflammatory clinical conditions, followed by a reduction after 7 days (KAYA et al, 2016;BOZUKLUHAN et al, 2018). FREITAS et al (2011 identified a gradual increase in ceruloplasmin in rabbits infected with Eimeria stiedai.…”

The use of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia

“…Gokce et al (2015) have reported that calves with rotavirus enteritis had higher Fb concentrations than calves with enteritis caused by E. coli. A recent study in calves with omphalitis has revealed that Fb concentrations are significantly increased before and after treatment (Bozukluhan et al, 2018). Similarly, in the present study, Fb concentrations were higher on day 0 in the SC than in the CC (P < 0.05), and Fb concentrations were lower on day 15 than on day 0 in the SC (P < 0.01) (Table 3).…”

“…In addition, Carter et al (2002) have stated that Hp concentrations are increased before treatment in the diseased calves compared to calves that received one or more than one treatment. Bozukluhan et al (2018) have reported that Hp concentrations are increased before treatment and after treatment in calves with omphalitis. Similarly, in the present study, Hp concentrations were higher on day 0 in the SC than the CC (P < 0.05), and the Hp concentrations were lower on day 15 than on day 0 in the SC (P < 0.01) ( Table 3).…”

“…On the other hand, Hp concentration for anticipation of morbidity and mortality is determined to be 0.13 g/L in calves younger than 4 months (Murray et al, 2014). Hp concentrations have been reported to significantly increase in calves with pneumonia (Carter et al, 2002;Ganheim et al, 2003;Tothova et al, 2010;Tothova et al, 2012), enteritis (Balikci and Al, 2014), bovine respiratory disease (Joshi et al, 2018), pneumoenteritis (Ganheim et al, 2007), omphalophlebitis (Tothova et al, 2012), omphalitis (Bozukluhan et al, 2018), and neonatal diarrhoea (Pourjafar et al, 2011). In addition, Carter et al (2002) have stated that Hp concentrations are increased before treatment in the diseased calves compared to calves that received one or more than one treatment.…”