Investigation of HPV Infection and P53 Expression in Laryngeal Verrucous Carcinoma

Tunçbilek, Mehmet Ali; Çallı, Çağlar; Öncel, Semih; Pınar, Ercan; Çallı, Aylin Örgen

doi:10.5336/medsci.2008-8340

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Of these 50 available cases, 68% were HPV positive. This finding is similar to the previously published studies of Kasperbauer et al, 16 which found 85% of LVC samples to be HPV positive, and another study by Tuncbilek et al 17 that found oncogenic HPV infection to be a potential contributor to the development of LVC. While this finding is in general accordance with the published literature, the relatively small number of patient cases available that include HPV data is a limiting factor and one most likely due to inconsistent tumor reporting among institutions.…”

Section: Clinical Characteristicssupporting

confidence: 92%

Laryngeal Verrucous Carcinoma: A Systematic Review

Echanique

Desai

Marchiano

et al. 2016

Otolaryngol.--head neck surg.

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Objective Laryngeal verrucous carcinoma (LVC) is a rare, locally invasive neoplasm comprising 1% to 3.4% of laryngeal carcinomas. Management strategies are a topic of ongoing conversation, and no definitive treatment protocol based on T stage and presentation exists. This review examines characteristics, treatment modalities, and patient outcomes of LVC. Data Sources PubMed, MEDLINE, EMBASE, and Web of Science. Methods Databases were searched through October 29, 2015, for literature detailing individual patient cases of LVC. Variables analyzed included patient demographics, tumor characteristics, tumor size, treatment, and outcomes. Results Thirty-seven articles with 369 cases were included. LVC was found more commonly in males (13.8:1), at an average age of 58.7 years, and located in the glottis (74.0%). Most patients had local disease at presentation (94.9%). The most common presenting symptom was hoarseness (92.3%). The most common primary treatment was surgery alone (72.3%), with local excision as the most common technique (56.8%). In patients with data available on both surgical modality and T stage, most patients who presented as T1 and were managed surgically underwent local excision (79.2%). Surgical treatment alone led to high rates of disease-free survival at follow-up (86.8%). A large number of patients presenting with T1 disease were disease free at follow-up (88.6%). Overall survival was 80.3%. Conclusion LVC is most often managed surgically. The extent of surgical resection may be guided by T stage, with smaller tumors resected via local excision and larger tumors via partial or total laryngectomy. Regardless of T stage or therapy, LVC has a good posttreatment prognosis.

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Section: Clinical Characteristicssupporting

confidence: 92%

Laryngeal Verrucous Carcinoma: A Systematic Review

Echanique

Desai

Marchiano

et al. 2016

Otolaryngol.--head neck surg.

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“…It is suggested that HPV acts as a carcinogen especially in cervical cancer and in other several epithelial malignancies, including cancers of skin, oral cavity, tongue, hypopharynx, larynx, esophagus, conjunctiva, bladder, urethra. [7][8][9][10] Although the association between high risk alpha HPV types (previously designated 'mucosal' types), such as HPV 16 and 18, and cervical cancer is well established, the role of infection with HPV in the development of NMSC is still unclear. [7][8][9] The first evidence for the involvement of specific HPV types in NMSC oncogenesis comes from studies in patients with epidermodysplasia verruciformis (EV).…”

mentioning

confidence: 99%

The Role of Human Papillomaviruses in the Development of Non-Melanoma Skin Cancers

Keseroglu¹,

İlter²,

Rota³

et al. 2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Non-melanoma skin cancers (NMSC) represent the most frequent cancers among the Caucasian population worldwide. The possibility of the involvement of human papillomavirus (HPV) in the development of these cancers is suggested by several studies. The purpose of this study is to evaluate the presence of various types of HPV in NMSC lesions of immunocompetent patients. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Biopsies taken from NMSC and non-sun exposed healthy skin from each of 32 immunocompetent patients were analysed for presence of HPV DNA by a polymerase chain reaction (PCR) using degenerate primers which can detect a broad spectrum of HPV types. R Re es su ul lt ts s: : HPV DNA was detected in one of 21 basal cell carcinomas, from one of two actinic keratosis and from none of 8 squamous cell carcinomas, and none of the control biopsy specimens. It was thought that in addition to factors associated with Turkish population, the specimens which were found to be HPV negative did not harbor HPV DNA, or although tissues harbor HPV DNA, it was not detected with the technique we used because of low viral load. C Co on nc cl lu us si io on n: : We could not show an association between HPV infection and NMSC by using real-time PCR technique. Our data suggest that the use of MY09/MY11 primer pairs alone in PCR technique is not sufficient to evaluate the HPV prevalence in NMSC. We thought that studies with more patients and using more sensitive detection techniques which will be developed in the future are needed to show a significant association between HPV and NMSC development.K Ke ey y W Wo or rd ds s: : Skin neoplasms; betapapillomavirus; polymerase chain reaction Ö ÖZ ZE ET T A Am ma aç ç: : Melanom dışı deri kanserleri (MDDK) dünya çapında beyaz ırkta en sık görülen kanserlerdir. Human papillomavirüslerin (HPV) bu kanserlerin gelişimine katkıda bulunuyor olabileceği birçok çalışmada öne sürülmüştür. Bu çalışmanın amacı, bağışıklık sistemi normal hastalardaki MDDK lezyonlarında farklı HPV tiplerinin mevcudiyetini değerlendirmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bağışıklık sistemi normal 32 hastanın her birinin MDDK ve güneş görmeyen sağlıklı derilerinden alınan biyopsiler, HPV tiplerinin geniş bir spektrumunu saptayabilen dejenere primerlerin kullanıldığı polimeraz zincir reaksiyonu (PZR) ile incelendi. B Bu ul lg gu ul la ar r: : HPV DNA, 21 bazal hücreli karsinomun 1 tanesi ve 2 aktinik keratozun 1 tanesinde saptanırken, 8 yassı hücreli karsinom ve kontrol deri örneklerinin hiçbirinde HPV DNA saptanmadı. Bu durumun, Türk toplumuyla ilişkili faktörlere ek olarak, HPV negatif olarak bulunan numunelerin HPV DNA içermemesine veya bu dokular HPV DNA içeriyor olmasına rağmen, viral yükün düşük olması nedeniyle bizim kullandığımız yöntemle saptanamamış olmasına bağlı olabileceği düşünüldü. S So on nu uç ç: : Biz çalışmamızda real-time PZR tekniği kullanarak MDDK ve HPV enfeksiyonu arasında ilişki gösteremedik. MDDK'de HPV pr...

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Investigation of HPV Infection and P53 Expression in Laryngeal Verrucous Carcinoma

Cited by 2 publications

References 30 publications

Laryngeal Verrucous Carcinoma: A Systematic Review

Laryngeal Verrucous Carcinoma: A Systematic Review

The Role of Human Papillomaviruses in the Development of Non-Melanoma Skin Cancers

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