Investigation of hs-TnI and sST-2 as Potential Predictors of Long-Term Cardiovascular Risk in Patients with Survived Hospitalization for COVID-19 Pneumonia

Fiedler, Lukas; Motloch, Lukas J.; Jirak, Peter; Gumerov, Ruslan M.; Davtyan, P. A.; Gareeva, Diana; Лакман, И. А.; Tataurov, Alexandr; Lasinova, Gulnaz; Павлов, В. Н.; Hauptmann, Laurenz; Kopp, Kristen; Hoppe, Uta C.; Lichtenauer, Michael; Pistulli, Rudin; Dieplinger, Anna-Maria; Zagidullin, Naufal

doi:10.3390/biomedicines10112889

Cited by 6 publications

(7 citation statements)

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“…On the contrary, in a recent study of 222 patients previously hospitalized in Aruba who participated in a survey at least 1 year after the onset of infection, neither demographics such as age or sex, nor obesity or concomitant respiratory diseases were predictors of post-COVID cognitive impairment [7]. Unclear remains also the prognostic role of laboratory parameters, such as increased troponin level, that has been shown to increase the risk of death [8] or hospitalization due to cardiovascular disease within 12 months after the SARS-CoV-2 infection [9]. However, the role of troponin as a possible predictor or marker of developing post-COVID syndrome, presenting with fatigue or brain fog, has not been accurately studied so far and therefore deserves more attention [10].…”

Section: Introductionmentioning

confidence: 99%

Association between brain fog, cardiac injury, and quality of life at work after hospitalization due to COVID-19

Chatys-Bogacka,

Mazurkiewicz,

Słowik

et al. 2024

Med Pr Work Health Saf.

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Background: To evaluate incidence and search for possible predictors of brain fog and quality of life at work (QoL-W) among low-to-moderate risk subjects previously hospitalized due to COVID-19. Material and Methods: Participants aged ≥18 retrospectively reported 8 brain fog symptoms pre-COVID-19, at 0-4, 4-12 and >12 weeks post-infection via validated clinical questionnaire. The QoL-W was assessed with a 4-point Likert scale where 0, 1, 2, and 3 meant no, mild, moderate, and severe impairment in performing activities at work, respectively. Data on age, sex, comorbidities, and laboratory results (including first in-hospital high-sensitivity cardiac troponin I [hs-cTnI] measurement) were gathered. Results: The study included 181 hospitalized subjects (age Me = 57 years), 37.02% women. Most had low disease severity (Modified Early Warning Score = 1, 77.90%) and low comorbidity (Charlson Comorbidity Index 0: 28.72%, 1-2: 34.09%), with no intensive care unit treatment needed. COVID-19 led to almost 3-fold increased brain fog symptoms, with incidence of 58.56%, 53.59%, and 49.17% within 4, 4-12, and >12 weeks, respectively (p < 0.001). First in-hospital hs-cTnI levels were 47.3% higher in participants who later presented with brain fog at median follow-up of 26.7 weeks since the diagnosis of the SARS-CoV-2 infection. Individuals who experienced at least one brain fog symptom at follow-up, had elevated hs-cTnI, less often presented with atrial fibrillation, and used anticoagulants during initial hospitalization due to COVID-19. The hs-cTnI >11.90 ng/l predicted brain fog symptoms in multivariable model. COVID-19 was associated with 3.6-fold, 3.0-fold, and 2.4-fold QoL-W deterioration within 4, 4-12, and >12 weeks post-infection (p < 0.05). Subjects with QoL-W decline >12 weeks were younger, mostly women, had more brain fog symptoms, and higher platelet counts. Multivariable models with self-reported brain fog symptoms (responding coherently and recalling recent information), age, and sex exhibited good discriminatory power for QoL-W impairment (area under the receiver operating characteristic curve 0.846, 95% CI: 0.780-0.912). Conclusions: This study highlighted that in non-high-risk subjects hospitalized during the first 2 pandemic's waves: 1) brain fog was common, affecting nearly half of individuals, and impacting QoL-W >12 weeks after initial infection, 2) after 3 months of COVID-19 onset, the decline in QoL-W was primarily attributed to brain fog symptoms rather than demographic factors, health conditions, admission status, and laboratory findings, 3) components of brain fog, such as answering in an understandable way or recalling new information increased the likelihood of significantly lower QoL-W up to tenfold, 4) biochemical indicators, such as the first hs-cTnI level, might predict the risk of experiencing brain fog symptoms and indirectly decreased QoL-W >12 weeks after COVID-19 onset. Occupational medicine practitioners should pay particular attention to younger and female subjects after COVID-19 complainin...

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Section: Introductionmentioning

confidence: 99%

Association between brain fog, cardiac injury, and quality of life at work after hospitalization due to COVID-19

Chatys-Bogacka,

Mazurkiewicz,

Słowik

et al. 2024

Med Pr Work Health Saf.

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“… 12 Elevação nos níveis aumentados de troponina durante a fase aguda da COVID-19 foi associada a complicações cardiovasculares em longo prazo, sendo um indicador de lesão miocárdica causada pelo SARS-CoV-2. 13 Este conjunto de evidências sugere que a COVID-19 pode aumentar o risco cardiovascular a longo prazo. 14 …”

Section: Introductionunclassified

“… 12 Troponin elevation during the acute phase of COVID-19 has been linked to long-term cardiovascular complications, being an indicator of myocardial injury caused by SARS-CoV-2. 13 This body of evidence suggests that COVID-19 may increase cardiovascular risk in the long term. 14 …”

Section: Introductionmentioning

confidence: 99%

Qualidade de Vida em Longo Prazo e Desfechos após Internação por COVID-19 no Brasil: Protocolo do Estudo Pós-COVID Brasil 1

Trott,

Scolari,

Rover

et al. 2023

Arquivos Brasileiros De Cardiologia

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Resumo Fundamento O impacto em longo prazo da hospitalização por COVID-19 sobre a saúde física, mental e cognitiva dos pacientes requer mais investigação. Objetivos Este artigo visa avaliar os fatores associados com a qualidade de vida e desfechos cardiovasculares e não cardiovasculares 12 meses após a internação hospitalar por COVID-19. Métodos Este estudo multicêntrico prospectivo pretende incluir 611 pacientes internados por COVID-19 (NCT05165979). Entrevistas telefônicas centralizadas estão programadas para ocorrer em três, seis, nove e 12 meses após a alta hospitalar. O desfecho primário é definido como o escore de utilidade de qualidade de vida relacionada à saúde avaliada pelo questionário EuroQol-5D-3L (EQ-5D-3L) aos 12 meses. Desfechos secundários são definidos como o EQ-5D-3L aos três, seis e nove meses, retorno ao trabalho ou à escola, sintomas persistentes, novas incapacidades em atividades instrumentais diárias, déficit cognitivo, ansiedade, depressão, e sintomas de transtorno do estresse pós-traumático, eventos cardiovasculares maiores, reinternação, e mortalidade por todas as causas aos três, seis, nove e 12 meses após a infecção pelo SARS-CoV-2. Um valor de p<0,05 será considerado estatisticamente significativo para as análises. Resultados O desfecho primário será apresentado como frequência do escore EQ-5D-3L 12 meses após a internação por COVID-19. Uma subanálise para identificar possíveis associações das variáveis independentes com desfechos do estudo será apresentada. Conclusão Este estudo determinará o impacto da COVID-19 sobre a qualidade de vida e de desfechos cardiovasculares e não cardiovasculares de pacientes internados 12 meses após a alta, e fornecerá novas informações ao sistema público de saúde no Brasil.

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“… 16 Estudos mostraram que a elevação dos níveis de troponina durante a fase aguda da COVID-19 está associada com desfechos cardiovasculares maiores em longo prazo, destacando a lesão miocárdica causada pelo SARS-CoV-2. 17 …”

Section: Introductionunclassified

“… 16 Studies have shown that troponin elevation during the acute phase of COVID-19 is associated with major long-term cardiovascular outcomes, underscoring the myocardial injury caused by SARS-CoV-2. 17 …”

Section: Introductionmentioning

confidence: 99%

Qualidade de Vida Relacionada à Saúde e Desfechos em Longo Prazo após COVID-19 Sintomática Leve: Protocolo do Estudo Pós-COVID Brasil 2

Rover,

Trott,

Scolari

et al. 2023

Arquivos Brasileiros De Cardiologia

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Investigation of hs-TnI and sST-2 as Potential Predictors of Long-Term Cardiovascular Risk in Patients with Survived Hospitalization for COVID-19 Pneumonia

Cited by 6 publications

References 53 publications

Association between brain fog, cardiac injury, and quality of life at work after hospitalization due to COVID-19

Association between brain fog, cardiac injury, and quality of life at work after hospitalization due to COVID-19

Qualidade de Vida em Longo Prazo e Desfechos após Internação por COVID-19 no Brasil: Protocolo do Estudo Pós-COVID Brasil 1

Qualidade de Vida Relacionada à Saúde e Desfechos em Longo Prazo após COVID-19 Sintomática Leve: Protocolo do Estudo Pós-COVID Brasil 2

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