Investigation of human papillomavirus in bladder cancer in a series of Tunisian patients

Selma, Walid Ben; Ziadi, Sonia; Gacem, Riadh Ben; Amara, Khaled; Ksiaa, Feriel; Hachana, Mohamed Ridha; Trimèche, Mounir

doi:10.1016/j.prp.2010.06.005

Cited by 29 publications

(39 citation statements)

References 29 publications

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“…These findings were very similar to those obtained from studies conducted in Egypt [19,28] and Italy [32]. In contrast, other studies reported no detection of HPV [7,26,33]. Several explanations of this variability have been proposed, including sampling problems, contamination, sensitivity of the detection systems, and geographic variation [34].…”

Section: Discussionsupporting

confidence: 87%

“…The association between HPV and bladder cancer has been explored in some studies in Africa. HPV was observed at a low percentage in South Africa (1.1%) [18] and no evidence of HPV infection was detected by morphological examination and PCR in any case of bladder carcinoma from Tunisian patients [7]. In contrast, a PCR-based study has revealed the detection of HPV DNA sequences in 49% cases of bladder cancer from Egyptian patients [19].…”

Section: Discussionmentioning

confidence: 88%

“…This possible relationship is based on the epithelial tropism of HPV and the anatomical proximity of the urethra, which is considered a reservoir for the virus, and the bladder [7,31]. In addition, a recent metaanalysis was conducted by a research group which has concluded that infection from high-risk HPV types, especially HPV16, may play a role in bladder carcinogenesis [17].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have investigated the association between HPV and bladder cancer in Africa. HPV was found to be rare in South Africa (1.1%) [18] and absent in Tunisia [7]. In contrast, a PCR-based study reported the detection of HPV DNA sequences in 49% cases of bladder cancer in Egypt [19].…”

Section: Introductionmentioning

confidence: 95%

“…According to the venereal transmission of HPV and to their ability to transform epithelial cells, the male urethra is considered as a reservoir for the virus. In addition, the association of HPV with bladder carcinomas has attracted much attention because of the epithelial tropism of HPV and the proximity of the urethra and bladder [7]. The papillomaviruses are small double-stranded DNA viruses which infect squamous epithelia and display a very high selectivity for the specific epithelium infected [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Human papillomavirus detection in Moroccan patients with bladder cancer

Berrada

Albouzidi

Ameur

et al. 2013

J Infect Dev Ctries

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Introduction: Human papillomavirus (HPV) is associated with more human cancers than any other virus. Many studies have investigated the association between bladder cancer and HPV but the results remain controversial. The aim of the present study is to evaluate whether HPV have an etiological role in bladder carcinogenesis among Moroccan patients. Methodology: Forty-eight fresh biopsies (43 bladder tumors and 5 non-tumor samples) were collected for this purpose. Nested PCR with the consensus MY09/MY11 and GP5

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Human papillomavirus detection in Moroccan patients with bladder cancer

Berrada

Albouzidi

Ameur

et al. 2013

J Infect Dev Ctries

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The association between human papillomavirus and bladder cancer: Evidence from meta‐analysis and two‐sample mendelian randomization

Sun

Liu

et al. 2022

Journal of Medical Virology

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Introduction Bladder cancer (BCa) is the 10th most common type of cancer worldwide, and human papillomavirus (HPV) is the most common sexually transmitted infection. However, the relationship between HPV infection and the risk of BCa is still controversial and inconclusive. Methods This systematic review and meta‐analysis were conducted following the PRISMA 2020 reporting guideline. This study searched four bibliographic databases with no language limitation. The databases included PubMed (Medline), EMBASE, Cochrane Library, and Web of Science. Studies evaluating the interaction between HPV infection and the risk of BCa from inception through May 21, 2022, were identified and used in this study. This study estimated the overall and type‐specific HPV prevalence and 95% confidence intervals (95% CI) using Random Effects models and Fixed Effects models. In addition, this study also calculated the pooled odds ratio and pooled risk ratio with 95% CI to assess the effect of HPV infection on the risk and prognosis of bladder cancer. Two‐sample mendelian randomization (MR) study using genetic variants associated with HPV E7 protein as instrumental variables were also conducted. Results This study retrieved 80 articles from the four bibliographic databases. Of the total, 27 were case–control studies, and 53 were cross‐sectional studies. The results showed that the prevalence of HPV was 16% (95% CI: 11%–21%) among the BCa patients, most of which were HPV‐16 (5.99% [95% CI: 3.03%–9.69%]) and HPV‐18 (3.68% [95% CI: 1.72%–6.16%]) subtypes. However, the study found that the prevalence varied by region, detection method, BCa histological type, and sample source. A significantly increased risk of BCa was shown for the positivity of overall HPV (odds ratio [OR], 3.35 [95% CI: 1.75–6.43]), which was also influenced by study region, detection method, histological type, and sample source. In addition, the study found that HPV infection was significantly associated with the progression of BCa (RR, 1.73 [95% CI: 1.39–2.15]). The two‐sample MR analysis found that both HPV 16 and 18 E7 protein exposure increased the risk of BCa (HPV 16 E7 protein: IVW OR per unit increase in protein level = 1.0004 [95% CI: 1.0002–1.0006]; p = 0.0011; HPV 18 E7 protein: IVW OR per unit increase in protein level = 1.0003 [95% CI: 1.0001–1.0005]; p = 0.0089). Conclusion In conclusion, HPV may play a role in bladder carcinogenesis and contribute to a worse prognosis for patients with BCa. Therefore, it is necessary for people, especially men, to get vaccinated for HPV vaccination to prevent bladder cancer.

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Association of human herpes, papilloma and polyoma virus families with bladder cancer

et al. 2012

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The aim of the present study was to assess the possible etiologic role of human papillomavirus (HPV), human herpes virus (HHV) and the human polyoma virus families (BKV and JCV) in the tumourigenesis of bladder cancer. Thirty biopsy specimens from patients with different grades and stages of bladder cancer, who underwent transurethral bladder cancer resection, and 30 normal bladder mucosa specimens were analysed using polymerase chain reaction (PCR) for the detection of the above three virus family members. The presence of HPV was determined in all specimens with nested PCR and real-time quantitative PCR. All cancerous specimens, including the control group, were found to be negative both by PCR and real-time qPCR for the presence of HPV DNA, whilst all samples examined by PCR tested negative for the presence of HSV-1,2 Varicella zoster virus and HSV-7 DNA. Cytomegalovirus, HHV-6 and HHV-8 exhibited similar incidence in sample positivity in both cancerous and healthy tissues. EBV showed a higher prevalence in bladder cancer specimens compared to healthy tissue (p = 0.048), whilst BKV and JCV were detected only in tumour samples. The presence of EBV in a significant proportion of bladder tumours indicates the etiological role of this virus in cancer tumourigenesis.

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Investigation of human papillomavirus in bladder cancer in a series of Tunisian patients

Cited by 29 publications

References 29 publications

Human papillomavirus detection in Moroccan patients with bladder cancer

Human papillomavirus detection in Moroccan patients with bladder cancer

The association between human papillomavirus and bladder cancer: Evidence from meta‐analysis and two‐sample mendelian randomization

Association of human herpes, papilloma and polyoma virus families with bladder cancer

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