In order to understand the instability characteristics of surrounding rock in the process of deep roadway excavation, a three-dimensional numerical model was established by FLAC3D to systematically analyze the influence of roadway surrounding rock stability under different in situ stress distribution forms, and the environmental coefficient of mining-induced stress η was defined, the larger the environmental coefficient of mining-induced stress is, the larger the surrounding rock stress environment is, and the range where the η coefficient is greater than 0.2 is called with the destruction-danger zone. When the initial vertical stress is maximum principal stress and minimum principal stress, by comparing the roadway along the middle ground stress direction and minimum or maximum in-situ stress direction, the variation characteristics of displacement, failure zone and failure hazard zone of roadway surrounding rock are obtained, which provides theoretical basis for the treatment of disaster accidents such as roadway surrounding rock instability and rock burst caused by deep high in-situ stress.