Investigation of
            <i>In Vitro</i>
            Antimicrobial and Cytotoxic Effects of Gold Nanoparticles Capped with Meropenem and Imipenem

Ciftci, Nurullah; Sargin, Idris; Arslan, Gulsin; Karakurt, Serdar; Arslan, Ugur

doi:10.2217/nnm-2023-0223

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…In this study, we investigate the deposition of gold and platinum nanoparticles, initially in a suspension, on silicon (Si) and oxide of silicon (SiO 2 ) substrates. The nanoparticles were synthesized using the well-established Turkevich method [31][32][33][34][35], as well as an ionic method employing silsesquioxane as a stabilizer [36]. To enhance adhesion of the nanoparticles in the substrate, poly(ethylene glycol) 6000 (PEG 6000) was used as a coating agent.…”

Section: Introductionmentioning

confidence: 99%

Novel deposition method for gold and platinum nanoparticles on silicon substrates utilizing poly (ethylene glycol) 6000 for MEIS analysis

Klippel,

Fonteles,

Torgo

et al. 2024

J. Phys. D: Appl. Phys.

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The use of nanoparticles has significantly increased in many areas, such as biomedical research, being highly useful as nanoprobes for imaging and as nanocarriers for drug delivery applications. Nevertheless, this potential can only be achieved with the correct characterization of the nanoparticles, since their size and shape can directly affect their biological behavior. \textcolor{red}{In this study, we propose a novel approach for a monolayer deposition of gold and platinum nanoparticles on Si substrates suitable for Medium Energy Ion Scattering (MEIS) analysis. The samples were prepared using PEG 6000 as a coating agent for the substrates, utilizing a spin coater—a versatile, cost-effective, and practical technique. The samples were first analyzed with the RBS technique to assess the adhesion and the overlapping of the nanoparticles in the substrates coated with PEG 6000 and then characterized through the MEIS technique.} The analysis through MEIS allowed the determination of the shape, size, and coverage area of the nanoparticles. Scanning and transmission electron microscopy were also performed on the samples, with the results corroborating the findings of the MEIS experiment. Together, the data obtained with microscopy and the MEIS technique suggests the effectiveness of the method in the production of monolayer samples.

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Section: Introductionmentioning

confidence: 99%

Novel deposition method for gold and platinum nanoparticles on silicon substrates utilizing poly (ethylene glycol) 6000 for MEIS analysis

Klippel,

Fonteles,

Torgo

et al. 2024

J. Phys. D: Appl. Phys.

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Metal nanoparticles and their toxicity impacts on microorganisms

Abishagu,

Kannan,

Sivakumar

et al. 2024

Biologia

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MAPLE-prepared graphene oxide-based coatings for improved orthopedic screws used in knee interventions

Constantinescu,

Gherasim,

Dorcioman

et al. 2024

Rom J Morphol Embryol

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Orthopedic screws are subjected to high mechanical stress, corrosive environment, and microbial colonization, which may cumulatively lead to implant failure and periprosthetic joint infections. To overcome these issues, this study has focused on modifying the surface chemistry and topography of screws utilized in knee intervention toward enhancing their mechanical and biological behaviors. Specifically, this study has explored the optimization of composite coatings made of polycaprolactone (PCL), graphene oxide (GO), and Meropenem (MRP) via the matrix-assisted pulsed laser evaporation (MAPLE) technique. The PCL/GO/MRP coatings aimed to upgrade the surfaces of the implantable fixation devices, offering superior antimicrobial properties, reduced biofilm formation, and better mechanical characteristics. Comprehensive physicochemical analyses, including Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and Raman microscopy, confirmed uniform deposition, efficient material transfer, and preservation of functional groups. The developed coatings displayed significant antibacterial activity against Staphylococcus aureus and Escherichia coli, with a marked reduction in biofilm formation compared to uncoated surfaces. Thus, this work highlights the potential of the designed PCL/GO/MRP coatings as a strategy to enhance the biocompatibility and longevity of orthopedic screws, minimize complications related to implant-associated infections in knee surgeries, and ultimately improve post-surgical outcomes to increase patients’ quality of life.

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Investigation of In Vitro Antimicrobial and Cytotoxic Effects of Gold Nanoparticles Capped with Meropenem and Imipenem

Cited by 3 publications

References 42 publications

Novel deposition method for gold and platinum nanoparticles on silicon substrates utilizing poly (ethylene glycol) 6000 for MEIS analysis

Novel deposition method for gold and platinum nanoparticles on silicon substrates utilizing poly (ethylene glycol) 6000 for MEIS analysis

Metal nanoparticles and their toxicity impacts on microorganisms

MAPLE-prepared graphene oxide-based coatings for improved orthopedic screws used in knee interventions

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