Investigation of Poly (ADP-Ribose) Polymerase-1 Genetic Variants as a Possible Risk for Allergic Rhinitis

Abstract

Recent studies point toward the involvement of poly (ADP-ribose) polymerase-1 (PARP-1) in the pathogenesis of allergic airway inflammation, such as asthma and allergic rhinitis (AR). It has been suggested that inhibition of PARP-1 provides significant protection against systemic or tissue inflammation in animal models. The objective of this study was to investigate whether single-nucleotide polymorphisms of PARP-1 gene are associated with genetic susceptibility to AR. We studied the effect of promoter variations and Val762Ala polymorphism of the PARP-1 gene on the risk for developing AR in a case-control association study with 110 RA patients and 130 control subjects in a Turkish population. The polymorphisms of 410 C/T, -1672G/A, and Val762Ala in the PARP-1 gene were analyzed using the polymerase chain reaction-restriction fragment length polymorphism method. Haplotype analysis of these groups was also performed. The results were statistically analyzed by calculating the odds ratio (OR) and their 95% confidence intervals using χ(2) tests. The heterozygote genotype of the promoter polymorphism (-1672) was significantly found to be associated with susceptibility to AR (OR: 0.56) among the tested single-nucleotide polymorphisms. Haplotypes of PARP-1 -410, -1672, and 762 were not associated with an increased risk for AR. These results raise the possibility that the promoter (-1672) polymorphism of the PARP-1 gene may be a risk factor for AR.

A General Sight about Linking PARP-1 and NFKB1 Variations to the Inflammatory Events

“…In haplotype analysis, PARP-1 C410T, G1672A and Val762Ala polymorphisms were not associated with an increased risk for AR. These results proved that the promoter G1672A polymorphism of the PARP-1 gene may be a risk factor for AR in Turkish population [79] (Tables 1 and 2). Graves' Disease (GD) is an organ specific autoimmune thyroid disorder characterized by diffuse goiter, hyperthyroidism, dermopathy, and an ocular disorder.…”

“…The pathogenesis of AR and other allergic diseases are developed by the exposure to irritating complex substances and in response to respiratory allergens [79].…”

Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases

“…In sensitized mice genetic ablation of PARP-1 or its enzymatic inhibition reduces inflammation and neutrophil infiltration, ameliorating allergic airway reactions, dyspnea and asthma-associated remodeling [109,110]. In humans, a PARP-1 gene polymorphism (Val762Ala) was reported to be associated with a decreased risk of asthma [111], while PARP-1 activation is increased in PBMC and lung tissues from asthmatic patients [112].…”

Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia

“…In recent years, the association of PARP1 gene with human diseases has been investigated extensively. Epidemical studies have indicated that the variations or polymorphism of PARP1 gene can affect the risk of some human disease, such as cancers, tourette syndrome, Alzheimer's disease, asthma and allergic rhinitis [27][28][29][30][31]. However, the effect of PARP1 gene on human Values are frequency (no.…”